Ecthyma

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PatientPlus articles are written by UK doctors and are based on research evidence, UK and European Guidelines. They are designed for health professionals to use, so you may find the language more technical than the condition leaflets.

See also: Folliculitis written for patients

Ecthyma is a cutaneous infection by Streptococcus pyogenes or Staphylococcus aureus with dermal extension. As it extends into the dermis, it is often referred to as a deeper form of impetigo.

  • There are no figures for incidence but it is more frequent in children and the elderly.
  • There is no apparent predilection for race or sex.

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Risk factors

  • Tissue damage from excoriations, insect bites or dermatitis and a compromised immune system as in diabetes or neutropenia, predisposes to the development of ecthyma. Other causes of immune compromise may include malignancy and HIV.
  • Poor hygiene aids spread as do overcrowded living conditions.
  • It is more common in hot and humid climates.
  • Untreated impetigo with poor hygiene may progress to ecthyma.
  • Malnutrition is also a risk factor.
  • Ecthyma starts like impetigo, sometimes in a pre-existing wound.
  • Ecthyma usually begins as vesiculopustules with a grey-yellow crust that evolves into shallow punched-out ulcers with a necrotic base and haemorrhagic crust.[1]
  • Lesions can be multiple and are commonly seen on the lower extremities.

Symptoms

  • Ecthyma usually arises on the lower legs or feet of children, those with diabetes, or neglected elderly people.
  • Lesions are typically painful with associated lymphadenopathy.
  • In tropical climates, ulcers are commonly found on the ankles and dorsum of the feet.

Signs

  • The most commonly affected sites are buttocks, thighs, legs, ankles and feet.
  • It starts as a vesicle or pustule over inflamed skin and then deepens to ulcerate with an overlying crust.
  • The crust is grey-yellow and is thicker and harder than the crust of impetigo.
  • A shallow, punched-out ulcer is seen if the crust is removed.
  • The deep dermal ulcer has a raised and indurated margin.
  • Ecthyma lesions may remain of constant size and resolve without treatment or they can enlarge to 3 cm in diameter.
  • Ecthyma heals slowly, usually with a scar.
  • Regional lymphadenopathy is common, even with solitary lesions.
  • Ecthyma gangrenosum (a similar condition caused by Pseudomonas spp.).[2] It tends to be more severe and, if diagnosis is delayed, there is a significant mortality.
  • Streptococcal ecthyma can mimic potentially serious zoonotic infections.[1] 
  • Ecthyma contagiosum is an alternative name for orf, which can look similar.[3] The diagnosis of orf is usually based on the patient's history of relevant exposure.
  • Also consider:
  • Swab for bacteriology.
  • Fasting glucose or HbA1c to exclude diabetes.
  • FBC for neutropenia.

Ecthyma is more likely to occur in association with diabetes or other conditions of immune compromise.

Non-drug

  • Treatment depends on the progression of the disease.
  • Hygiene is important. Use bactericidal soap and frequently change bed linens, towels and clothing.
  • Remove crusts and apply an antibiotic ointment daily.
  • Povidone-iodine and hydrogen peroxide may be used as antiseptics.

Drugs

  • Topical mupirocin ointment is very effective. Fusidic acid and retapamulin are alternatives. Topical antibiotics are usually satisfactory if the infection is localised.
  • More extensive lesions require oral antibiotics, possibly for several weeks to obtain full resolution.
  • Penicillin should be adequate to treat streptococci.
  • If S. aureus is also present, an antibiotic resistant to penicillinase may be advised.
  • Consider parenteral antibiotics if there is widespread involvement.

Surgical

Gently debride the crusts if they are extensive.

Healing is slow with scar formation but response to appropriate antibiotics occurs over several weeks.

In tropical climates, pay attention to hygiene and use insect repellents to reduce bites.

Further reading & references

  1. Orbuch DE, Kim RH, Cohen DE; Ecthyma: a potential mimicker of zoonotic infections in a returning traveler. Int J Infect Dis. 2014 Dec;29:178-80. doi: 10.1016/j.ijid.2014.08.014. Epub 2014 Oct 25.
  2. Vaiman M, Lazarovitch T, Heller L, et al; Ecthyma gangrenosum and ecthyma-like lesions: review article. Eur J Clin Microbiol Infect Dis. 2015 Apr;34(4):633-9. doi: 10.1007/s10096-014-2277-6. Epub 2014 Nov 19.
  3. Meier R, Sommacal A, Stahel A, et al; Orf - an orphan disease? JRSM Open. 2015 Jul 7;6(6):2054270415593718. doi: 10.1177/2054270415593718. eCollection 2015 Jun.
  4. Ecthyma (including ecthyma gangrenosum); Primary Care Dermatology Society (PCDS), July 2015
  5. Ecthyma; Lippincott's Guide to Infectious Diseases
  6. Kulhankova K, King J, Salgado-Pabon W; Staphylococcal toxic shock syndrome: superantigen-mediated enhancement of endotoxin shock and adaptive immune suppression. Immunol Res. 2014 Aug;59(1-3):182-7. doi: 10.1007/s12026-014-8538-8.

Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.

Original Author:
Dr Richard Draper
Current Version:
Peer Reviewer:
Dr Laurence Knott
Document ID:
2087 (v23)
Last Checked:
12/10/2015
Next Review:
10/10/2020

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