Can't sleep itching fluoxetine week 2! Help!

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Hi I've been on fluoxetine 20mg for two weeks, i came off sertraline 100mg and straight into

These I had been on sertraline over a year and it stopped working. I am itching like mad on a night last night and tonight I already suffer physical urticaria and have for a few years but this isn't hives present just itching please tell me it will lessen! Thanks every body x

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3 Replies

  • Posted

    This sounds to me like an allergic reaction to the fluoxetine!  If you've had urticaria, you might consult an allergist about Mast Cell Activation Syndrome, an emerging medical topic (within the past 10 years) - mast cells can play havoc with the entire body and the Autonomic Nervous System (not just the skin and nose), and when the ANS is upset, all sorts of circulatory, digestive, metabolic, endocrine, and immune system problems can pop up and consciously manifest as anxiety.  Prozac may even be a mast cell activator.

    • Posted

      Hi Jane this has set me off in a massive worry, is that a serious condition coils something bad happen to me? I started with urticaria during pregnancy I was referred to a specialist who said the change in hormones had started off the uticaria & it would either settle when my baby was born or stay, I have physical uticaria so it's whenever I'm hot or physically active sometimes when I'm stressed. The itching starts at night at the moment just before bed when I go in the bath, no hives are present. I've seen a specialist a few times and also & consultant about the hives I am on 180mg of antihistamine every day twice if needed which it was needed lastnight. I'm quite worried now that I have something wrong and will die when I'm itching 😩 Anxiety is evil x

    • Posted

      It's not "serious", very treatable with the right meds, but a vast majority of doctors and specialists don't know about mast cell syndromes and disorders and patients end up spending months if not years running from specialist to specialist trying to find the causes of weird symptoms and thinking the worst and being called hypochondriacs and given the worn out speech to "stop worrying".  An allergist is needed who is familiar with MCAS or MCAD or mastocytosis and the research that has been done within the past 10 years (which hasn't made it into medical schools yet).  A dermatologist should have some idea of mastocytosis, but probably not how it can affect all areas of the body not just the skin (as most specialists seem to know only what's in their little "box"wink.  A couple of mast cell websites have mentioned allergies and itching with Prozac, you need to work with your doctor and get off as soon as you can.  Urticaria is a big flag that your mast cells are producing way too much histamine, which can upset your Autonomic Nervous System which can then start sending "fight or flight" signals to the rest of your body, to the circulatory (palpitations and racing heart), digestive (upset), respiratory, metabolic (hot flashes), endocrine, and immune systems.  Your conscious brain detects the body is in "fight or flight mode" but doesn't understand why (it's not like you're in the park and an errant frisbee is heading straight for your face) hence the anxiety.  You may need additional antihistamines and to identify what is triggering your histamines.  Maybe even food allergies such as soy, wheat or corn (3 of the big 8).  Getting your immune system under control, you may no longer even need SSRIs like Zoloft.  Good luck.

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