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Ibruprofen and Tramadol

Is it safe to take Ibruprofen and Tramadol together?

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  • Benny Blanco

    Generally speaking yes but if you are having Stomach problems on top of whatever else is going on then take it easy on the Ibuprofen,, but yeah you can take Ibuprofen, Paracetamol and Tramadol all lumped together and it gives em all a good boost smile

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  • Fred Flintstone

    Thanks for your reply.

    I dont have too many stomach issues now, I recently had my gall bladder removed. I usually take just one Tramadol or with 2 paracetamol, and have found that if I take these late at night then the pain I take them for which I have mentioned on here previously seems to not be too bad at all for most of the following day.

    Does that sound common?

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  • Benny Blanco

    Tramadol is a good painkiller but it works far better when taken with something else (Paracetamol or whatever), it also makes it far less likely that you'll develop a habit if you're taking it long term wink Mr Flintstone, the thing with pain is you can reset it (unless it's completely terrible of course) and Tramadol is good at resetting it (it's fairly long lasting), but as you have noticed the pain can and will slowly but surely creep up again rolleyes

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  • Benny Blanco

    Yes, Ibuprofen or Ibuprofen and Paracetamol, either or both, Ibuprofen is particularly good for Gallbladder area pain in my experience, but read about the possible Stomach side effects in the accompanying leaflet wink

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  • NBarnes

    Hi, I've been using tramadol for about 9 months now. Its perfectly fine to take ibuprofen and paracetamol alongside tramadol but remember that ibuprofen can cause stomach/liver issues when taken long-term.

    I was prescribed tramadol and paracetamol at the same time, as paracetamol can greatly improve the effectiveness of tramadol. I'm not sure how exactly but several GPs and Pain Management specialists confirmed this.

    I'd highly recommend anyone on tramadol who isn't getting much relief to try taking 1 or 2 paracetamol tablets at the SAME time as their tramadol dose. I think there may even be a tramadol/acetaminophen (paracetamol) pill available on prescription.

    As always, talk to your GP, Pharmacist or even NHS Direct before mixing medications and look out for any contraindications on the patient information leaflet in the medication's box.

    Also, don't suffer in silence! If the tramadol doesn't work out, go back to your GP and discuss other options. I've just changed to a stronger pain killer as the tramadol lost its effectiveness after 9 months of heavy use!

    Hope this helps, this is my first post on so apologies if its a bit long!


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  • Fred Flintstone

    Hi Nick, and welcome to the forum.

    When you mention that its perfectly fine to take ibuprofen and paracetamol alongside tramadol, I take it that you don't mean all together at the same time? I have taken like one 50mg tramadol capsule together with 2 500mg paracetamol capsules, and I have often wondered if I could take 2 tramadol 50mg with the 2 paracetamol capsules at the same time, but like I say I don't suppose it's advisable to take all 3 which includes the ibruprofen, but I may be wrong of course.

    I have had issues with stomach and colon and had my gall bladder removed, so maybe I should think twice before I take the ibruprofen.

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  • NBarnes

    Hey Mr Flintstone,

    Thanks for the welcome!

    I would normally take all three at the same time when needed but I have no history of stomach problems. For you, it might be better to take the tramadol and paracetamol at the same time and then after an hour or two take some ibuprofen - if you still need it. This little gap between doses might give your stomach some time to 'recover' slightly?

    I have only been advised about a positive interaction between tramadol and paracetamol, not ibuprofen. What I mean by this is, you only need to take tramadol and paracetamol at the same time to get the improved pain relief. Adding ibuprofen might give some extra relief but only by acting on its own and not by combining itself with the tramadol like paracetamol does.


    Tramadol + Ibuprofen = Tramadol + Ibuprofen

    Tramadol + Paracetamol = Super Tramadol!

    Tramadol + Ibuprofen + Paracetamol = Super Tramadol + Ibuprofen

    Hope that makes sense!? Really difficult to explain and I don't want to confuse anyone who might be 'self-medicating'. Obviously anyone who is unsure should talk to their GP.

    Have you taken much ibuprofen since your stomach problems began? If not, I would skip the ibuprofen altogether and just take paracetamol and tramadol. You wouldn't want the tramadol to cover up any stomach pains caused by the side-effects of ibuprofen!

    I would also talk to your GP about ibuprofen and other non-steroidal anti-inflammatory drugs like diclofenac (voltatol) etc. Ask whether the stomach/liver related side-effects of these drugs is more risky considering your medical history. At least then you know if ibuprofen is ever going to be a suitable drug for you.

    Until this morning, when I changed to a stronger pain killer, I would ALWAYS take paracetamol with my tramadol. Its just more effective that way but when you start feeling that you need to take something like ibuprofen on top of that, for sustained periods of time, that's when you need to go back to the GP and ask for something stronger!

    Wow! Another long post! Hope it helps smile


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    • Rudaga NBarnes

      Thank you for this information Nick - it has been extremely helpful.  My husband has just had a hip replacement - he's relatively young for this kind of operation and as a result the muscle pain is quite intense!  We needed to know whether or not he could combine the Tramadol with paracetamol and ibuprofen as none were sufficient on their own.  THANKS AGAIN!


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  • Fred Flintstone

    When you mentioned anti-inflammatory drugs it then remembered me that I had an anti-inflammatory injection for coccyx pain just more than a year ago, and it was around 2 weeks later that I had stomach pain and severe nausea, this lasted for quite some time, and I have a strange feeling it was this that caused my initial problems, oh and that as well as Gall stones.

    It's about 7 weeks since I had my gall bladder removed, and only now am I getting some pain relief, at the right hand shoulder blade area, I still get little feelings, but no so that I need to lie down, and lying down would often help the pain.

    I have also read with interest that people with Barrett's and or stomach issues shouldn't really have these type of injections, especially the blind ones as if it isn't done right a clot can form, and that is why an x-ray should be performed to be used as guidance.

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  • NBarnes

    In that case, if I were you I'd stay away from ibuprofen etc. until you can discuss it properly with your GP.

    A member of my family took ibuprofen for too long and now can't touch the stuff, it really messed their digestive system up!

    I hope you find some relief soon! I know how difficult it can be getting the right pain meds sorted so good luck!


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