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Implications of meds on NASH (non alcoholic steatohepatitis)

Posted , 4 users are following.

Red_Rose
Red_Rose

Along with my diagnosis of Fibromyalgia came a diagnosis of NASH. I've only just realised this when I came across the diagnosis letter recently.

I struggle with Fibro pain at times and now also lower spine pain, I'm doing myself no favours by taking less than prescribed meds but I am worried about effects on my liver.

Anyone able to offer some advice.

Also, surely with NASH, shouldn't I have regular let tests?

1 like, 3 replies

3 Replies

  • fibrogirl1
    fibrogirl1 Red_Rose

    Posted

    I don't know anything about NASH, but I know what you mean about the meds.  My liver function has been a little off and I don't even take that much since it doesn't help that much.  It's a fine line.

  • cherub123
    cherub123 Red_Rose

    Posted

    your doctor is the best person you should ask for advice about your medication. taking less medication will only make the pain worse for you.. if you are worried speak to a specialist and explain your worries to him/her. having Nash is something you should always have regular tests for. so it is very important to you see your doctor or specialist at the local hospital and get checked out and explain what you are going through.
  • UKSteve
    UKSteve Red_Rose

    Posted

    Hi Red Rose

    This is best discussed with your doctor or hepatic specialist or the hospital pharmacist

    You will need to go through the lists of available fibro meds with them so that any known to be particularly toxic to the liver can be avoided.

    For example Cymbalta (Duloxetine) is hard on the liver and is contraindicated with people who have liver

    disease. Opiate pain meds are usually ok at low to moderate doses ,providing your liver condition is not advanced to fibrosis or cirrhosis because there may be a risk of over sedation and encephalopathy

    A similar but lower risk occurs with amitriptyline because of its sedative effects.

    Other meds such as Pregabalin, Gabapentin, and most of the NSAID's are primarily metabolised by the kidneys and you not therefore propose much risk to the liver.

    Paracetamol ( acetaminophen) of course you probably know must be carefully controlled.

    Overall I think you will find that you will most likely be ok with most of the key listed medicines for fibromyalgia just ensure that you gets regular blood test to monitor any impact on your liver

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