Ramipril dull headaches

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Im a 32 yo male and was admitted to hospital with a blood pressure of 245/150 severe hypertension.

I was given 2.5mg of Ramipril increased by my GP to 5mg as BP still high. BP recorded 3 times a day vary from highest 175/92 to 147/81 lowest.

I felt fine before starting these tablets but when I went back to the doctor and told her that I was getting dull headaches and dizziness she said it was just the side effects. It seems to get easier to deal with each day but tonight I had a headache and checked my BP and it was 134/79 the lowest reading so far.

Basically my worry is that although my blood pressure is coming down with Ramipril 5mg I know that she will want to increase the dosage and then I will feel lousy again.

I suspect the fact that my body has been used to dealing with severe high BP for so long that now its dropping much lower in such a short time that is the reason for my headaches/dizziness, sort of backed up by my lowest reading when having a headache. God knows how I will feel if my BP gets down to a normal level....should I try and avoid increasing the dose until I am used to the level 5mg has me at?

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  • Posted

    Your GP should do some tests after you start the medication, say two weeks into it, for example with Perindopril he may do a blood test to see if your live or some other organ is being affected.  Some GPs seem not to bother with that.  So first check these types of requirements for it is possible your GP for some reason failed to do that for a particular drug.  I am not a medical doctor but I know that there are many mechanisms responsible for high blood pressure and so it is not just an issue of the dose and how quickly or slowly your body (parmacokinetics and pharmacogenomics) processes the drug, there is more.  You may have a mechanism X and me a Y and another guy a Z.  Until such time as personalized genomic medicine comes to everyday use, you and I and everyone else will be given drugs based on statistical findings for race and age (middle aged Caucasian males should take drug X and Y).  It would be risky to advise but I would say, based on your discussion, that you should accept a low blood pressure of 90 or just under 90 and not worry too much.  What you wish to avoid is a low of 100 or 110, but in any case you are young at 32 to worry excessively.  Another thing you must do for the future: take daily pill of vitamic C 1000 mg and take one or even two pills of omega 3 fish oil.  The former will improve your immune system and protect you from systemic diseases which harbour inside of us and eventually surface and kill us when we are weak (bacteria, viral cancers, certain cancers that are dormant for say a decade and then come out).  The latter, in the long run, will protect your cardiovascular system perhaps even reversing bad cholesterol and narrowing or arteries.  And there my knowledge stops but please consult doctors.  Hopefully in 10 years when you are 42 there will be affordable gene sequencing and also personalized medicine that will remove your blood pressure problem.
    • Posted

      Thanks for the info Daniel. I have had blood tests at the hopsital which came back fine and then further blood tests that my GP said that I had slightly high bad cholesterol and 1 high enzyme in my liver possibly due to fatty cells???....Dont really understand the liver bit but both my mother and grandmother have high BP and its probably just a genetic thing but I know I need to lose weight and improve my diet/lifestyle to help myself out. I have also accepted that I need to take the medication for prob the rest of my life but what I cant accept is that people are just expected to put up with side effects and use a trial and error approach to treatment. If say after a few months and the correct dosage being worked out the headaches would go away then I would be fine with that but I am just worrying that I will be going through all this and then have to try another drug and a whole new set of possible side effects. Do you think once my body gets used to the correct BP levels from the treatment the headaches will stop?
    • Posted

      What I was saying is that the side effects (perhaps) could be diminished if you take less of the drugs.  For example, it seems the drug stays in your body longer than for other people because: (a) it had a rather dramatic effect to reduce your blood pressuer and (b) you had a side effect which you noticed easily - for example you are not in doubt whether it was this medicine or something else.  Hence, my advice to you is to take less of the pills, smaller dose and see what BP you achieve. Going from a low of 150 to 92 is an amazing improvement.  The drugs are not that good!!! do you understand?  So it means you are overdosing a bit on the drug, that your body piles it up.  You got to 79 amazing! incredible.  Say in my case with Perindopril and amlodipine high doses I could only take it down from 115 or so to 91 or so.  My adfive is that you do not pay any attention to this 120/80 myth objective.  You have to accept something reasonable.  Even at your age, having  a low of 90 is fine, it will do your heart no damage at all.  It may make your heart stronger.  When you get to 45 years of age then you have to see if you are still at 90 or if you are now back to 95 or so but what I am telling you is that by the time you get to age 45 medicine will have advanced sufficiently and other drugs or procedures will be available for your precise genotype, sequencing your genome will cost 200 GBP at most! and so you will be cured.
  • Posted

    I don't know what to say to you, since I am so new at this HBP thing!  I am sorry to hear that you are experiencing such problems at such a young age.  I am 65, and my blood pressure was normal in 2010 (the last time it was taken at my surgery) but sometime in the intervening years, it became very high, although I had no symptoms! I have high cholesterol, too and my Doctor will prescribe statins when I see him in a few week's time, but he didn't want to put me on two new drugs at the same time. I do not smoke, drink, nor am I overweight, so I suppose in my case it is a matter of age and genetics. I had visited my Doctor on a few occasions during those years, but at no time did I have my blood pressure checked, despite the fact that it only takes a couple of minutes, and costs nothing.   In hindsight, I think everyone should check their blood pressure themselves, as monitors are very cheap, and I could have avoided the scenario of suffering uncontrolled high blood pressure for a unknown length of time!  I am prone to suffering migraines, so am dreading getting headaches on Rampiril, since I don't think I will be able to take my usual medication, which is a vaso-constrictor (Imigran).........
    • Posted

      The way I look at it I am very lucky to have found it early on and the only issue I have is the dull headaches from my blood pressure dropping due to medication. I can deal with eating right, exercising and taking pills for the rest of my life if it keeps me from having health issues in the future but just hoping the headaches are a side effect that will pass when I get used to the meds rather than being told to deal with them. I am sure ramipril reacts differently with everyone so hopefully you woudlnt experience the same side effect as I do with it and if once my BP is controlled at a healthy level I still get them then I will just have to try something else.
  • Posted

    I don't think you should have to put up with side effects. Ramipril is well known for the cough and routinely the dr will change you to Losartan or similar. However the cough  doesn't seem to be your problem. There are many other medicines and combinations for hypertension that your dr could try you with. It is usually just a trial and error to find the right one for you - we are all different.

    You should also tell the pharmacist about the side effects. When I first went on meds the pharmacist was very thorough and asked for feed back and even phoned after a few weeks to see how things were going. Sometime pharmacists have more time than the drs who can be quite dismissive of side effects.

    Lifestyle changes however will also help. Cut out salt and sugar, you won't miss either  after a week or so, lose weight if you need to, lower your alcohol intake also if you should and it goes without saying don't smoke! On top of all that do sufficient exercise. At least 30 mins brisk walking on at least 5 days a week is good, every day would be better. Don't expect miracles overnight but if yu keep at it your BP should drop somewhat even without meds. You'll certainly feel better.

    • Posted

      Hi Jane. I have just re enforced what you told Mark. You and me sing off the same hymn sheet re lifestyle don't we?!!!!

      I went out for a family birthday meal during the week and had a lovely meal WITH A PINT OF BEER! It was lovely and I enjoyed it more than when I was drinking 3 or 4 times a week.

      Have a good weekend.

    • Posted

      Hi Jane. I have just re enforced what you told Mark. You and me sing off the same hymn sheet re lifestyle don't we?!!!!

      I went out for a family birthday meal during the week and had a lovely meal WITH A PINT OF BEER! It was lovely and I enjoyed it more than when I was drinking 3 or 4 times a week.

      Have a good weekend.

    • Posted

      Hi Jane. I have just re enforced what you told Mark. You and me sing off the same hymn sheet re lifestyle don't we?!!!!

      I went out for a family birthday meal during the week and had a lovely meal WITH A PINT OF BEER! It was lovely and I enjoyed it more than when I was drinking 3 or 4 times a week.

      Have a good weekend.

  • Posted

    You say that your body has been used to dealing with severe BP for so long?

    How long is that and is it only now being treated? My body is also used to my BP being high and I can always tell from the way I feel when it goes down to what is regarded as normal.

    A GP is not the right person to deal with the level of BP that you have. Insist on being referred to a Hypertension Referral Centre to see a proper specialist, not a cardiologist. Google for one near you but they are few and far between.

    NICE guidlines say that patients with BP over constantly over 168 should be referred to one.  First as you admit you need use will power to change your lifestyle.

  • Posted

    Hi Mark. Jane and Derek have said pretty much what I would have said.

    I have been on 10mgs Ramipril for about 5 years due to my previously high BP. I am also on 10mgs statins. 

    My father died of a stroke after having a series of mini strokes. My BP, like so many, is partially inherited.

    You should not put up with unwelcome side effects. See you GP. Make a daily diary of your BP readings, your weight and how you feel. Show your GP. Take charge of your body as no one will look after it as well as you can.

    Now this next bit may not apply to you in which case ignore it. If you are overweight, lose weight. Stop smoking. Stop ALL alcohol for 4 weeks. Tell you why in a minute. Don't eat junk food. Eat veg and fruit. No added salt to food. Reduce coffee and tea to max of either 4 cups per day. Eat beetroot. Add garlic to meals. Exercise for at least 30 mins a day.....to a point where heart rate is raised. Start now. Keep a log. In 4 weeks your BP should be consistenly lower and you can re introduce alcohol as a TREAT. These are lifestyle changes. Harsh at first but you will embrace them because you should see a change for the better.

    Good luck. Keep us all posted.

    • Posted

      No probs Mark. I meant to say.....also get family and friends to support you. Very important.
  • Posted

    It took me quite a few months to get used to taking tablets I did find when I felt dizzy I drank quite a bit of water which seemed to help.  I believe being dehydrated can increase blood pressure as well. It's worth giving it a go ,a lot of us don't drink enough
    • Posted

      It took me quite a few months to get used to taking tablets too, I think it was the psycological effect of feeling pills were 'for life'. I still absolutely hate it and feel trapped.

      I'm sure you're right about us not drinking enough water. I know I should drink more than I do and your comments have prompted me to do so.  

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