1. Community
  2. Ears, nose, throat and mouth
  3. Granulomatosis with Polyangiitis

Rituximab and methotrexate

Posted , 3 users are following.

courtney_71550
courtney_71550

My husband has had hoarseness and been coughing for about a month. He went to the Dr. On Wednesday and they started him on methotrexate and they want him to get 1 round of chemo (4 infusions) soon. Is anyone else on both medications at the same time? I just think it's a lot! But I'm no Dr. Either and want what's best for my husband.

0 likes, 4 replies

4 Replies

  • jennifer25546
    jennifer25546 courtney_71550

    Posted

    Well my Dr. said hoareness has nothing to do with wg for me mine comes and goes. I think I need new Dr.
    • courtney_71550
      courtney_71550 jennifer25546

      Posted

      I read on web md or some website hoarseness can be a symptom and with my husband WG affects his respiratory system, he already has scaring in his lungs and his dr. Told him that the swelling he is feeling in his throat along with the hoarseness is the WG coming back, because of the possibility of his windpipe collapsing he needed to be treated.

      I hope that you find the right Dr. We are seeing a rheumatologist and he is the only Dr. we finally trust and like. Best wishes to you!

    • jennifer25546
      jennifer25546 courtney_71550

      Posted

      I read that also and I have breathing problems also. Lung Dr. Said Copd never put it with wg . But before diagnose it was that.
  • dave170448
    dave170448 courtney_71550

    Posted

    Hi Courtney

    I've not been on both together. This may help? ..

    Summary features of the NICE guidance relating to the use of rituximab is outlined below:

    rituximab in combination with methotrexate is recommended as an option for the treatment of adults with severe active rheumatoid arthritis who have had an inadequate response to or intolerance of other disease-modifying anti-rheumatic drugs (DMARDs), including treatment with at least one tumour necrosis factor a (TNF-a) inhibitor therapy

    treatment with rituximab plus methotrexate should be continued only if there is an adequate response following initiation of therapy. An adequate response is defined as an improvement in disease activity score (DAS28) of 1.2 points or more. Repeat courses of treatment with rituximab plus methotrexate should be given no more frequently than every 6 months

    treatment with rituximab plus methotrexate should be initiated, supervised and treatment response assessed by specialist physicians experienced in the diagnosis and treatment of rheumatoid arthritis

Back to top

Report or request deletion

Thanks for your help!

We want the community to be a useful resource for our users but it is important to remember that the community are not moderated or reviewed by doctors and so you should not rely on opinions or advice given by other users in respect of any healthcare matters. Always speak to your doctor before acting and in cases of emergency seek appropriate medical assistance immediately. Use of the community is subject to our Terms of Use and Privacy Policy and steps will be taken to remove posts identified as being in breach of those terms.