Cervical Disc Protrusion and Lesions

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PatientPlus articles are written by UK doctors and are based on research evidence, UK and European Guidelines. They are designed for health professionals to use, so you may find the language more technical than the condition leaflets.

See also: Nonspecific Neck Pain written for patients

The intervertebral discs lie between adjacent vertebrae. They consist of a peripheral fibrocartilaginous part called the annulus fibrosus and a central semifluid/gelatinous part called the nucleus pulposus.

  • There is no disc between C1 and C2 (atlas and axis), and only ligaments and joint capsules limit excessive motion.
  • Disc degeneration or herniation can injure the spinal cord or nerve roots.
  • Cervical radiculopathy is compression or injury to a nerve root in the cervical spine. Its most common causes are cervical disc herniation and degenerative disease.[1] 
  • The term myelopathy is used to describe any neurological deficit related to the spinal cord itself. Myelopathy may be due to compression of the spinal cord by a prolapsed cervical disc.
  • There are separate articles on Neck Pain (Cervicalgia) and Torticollis, Cervical Spondylosis, Whiplash and Cervical Spine Injury and Spinal Cord Injury and Compression.

Cervical disc disorders can include:

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Disc herniation (prolapsed intervertebral disc)

  • The nucleus pulposus bulges or breaks through the annulus of the disc.
  • It may occur from a single whiplash injury but repetitive injuries are more common.
  • Cervical disc herniation occurs most frequently at the levels of C4/5, C5/6, and C6/7.
  • Posterior herniation causes symptoms by compressing the cord or a nerve root, or by stretching the posterior longitudinal ligament or posterior annulus.

Degenerative disc disease (cervical spondylosis)

  • The exact cause of this is not known. Some suggest that it is a natural part of ageing; however, disc degeneration can also occur in young people. The cause is likely to be multifactorial, including genetic, environmental, traumatic, inflammatory, infectious and other factors.
  • Annular tears, internal disc disruption and resorption, disc space narrowing, disc fibrosis and osteophyte formation can all occur.
  • Degenerative disc disease may lead to disc herniation.
  • There is a separate article on Cervical Spondylosis.

Internal disc disruption

  • This includes damage to the disc without external deformity.
  • It may result from whiplash or other trauma to the neck.
  • Degenerative disc disease can progress to internal disc disruption.
  • There is a separate article on Whiplash and Cervical Spine Injury.

Infection (discitis)

See also the separate article on Examination of the Spine. During assessment of a patient with neck pain, always be alert to red flag symptoms or signs.

A serious underlying cause is more likely in people presenting with:
  • New symptoms before the age of 20 years or after the age of 55 years
  • Weakness involving more than one myotome or loss of sensation involving more than one dermatome
  • Intractable or increasing pain
Red flags suggesting possible malignancy, infection or inflammation:
  • Fever
  • Unexplained loss of weight
  • History of inflammatory arthritis
  • History of malignancy, drug abuse, tuberculosis, AIDS, or other infection
  • Immunosuppression
  • Pain that is increasing, unremitting and/or disturbs sleep
  • Lymphadenopathy
  • Exquisite localised tenderness over a vertebral body
Red flags suggesting myelopathy (compression of the spinal cord):
  • Insidious progression
  • Gait disturbance; clumsy or weak hands; loss of sexual/bladder/bowel function
  • Lhermitte's sign (flexing the neck causes electric shock-like sensations that extend down the spine and shoot into the limbs)
  • Upper motor neurone signs in the lower limbs (Babinski's sign - up-going plantar reflex, hyperreflexia, clonus, spasticity)
  • Lower motor neurone signs in the upper limbs (atrophy, hyporeflexia)
  • Variable sensory changes (loss of vibration and joint position sense more evident in the hands than in the feet)
Red flags suggesting severe trauma/skeletal injury:
  • History of trauma
  • Previous neck surgery
  • Osteoporosis or risk factors for osteoporosis
  • Increasing and/or unremitting pain
Red flags suggesting vascular insufficiency:
  • Dizziness and blackouts (restriction of vertebral artery) on movement, especially on extension of the neck with upward gaze
  • Dizziness, drop attacks


  • If there was an injury, note the time since the injury and the mechanism.
  • Ask about the pain:
    • Note the distribution. Neck pain can radiate to an upper limb. Pain is usually unilateral, but may be bilateral. Pain can disturb sleep. Neck pain is frequently absent in radiculopathy.
    • Ask about speed of onset. Insidious onset of symptoms is usual in cervical radiculopathy but it may be abrupt in acute injury.
    • Pain from the disc without nerve root involvement is typically vague, diffuse, and distributed axially.
    • Activities that raise pressure in the disc such as lifting or a Valsalva manoeuvre will exacerbate symptoms. Lying down decreases pressure in the disc and eases pain.
    • Driving causes vibration that aggravates disc pain.
  • Make a systematic enquiry about general health. Fever suggests infection. Unintentional weight loss suggests malignancy.


  • If pain originates from the disc but there is no nerve root involvement, there will be normal neurological examination.
  • Tenderness with movement in the posteroanterior plane may suggest disc pathology.
  • Signs of radiculopathy on examination:
    • The neck will show a decreased range of movement. This is very common with pain and spasm from any cause.
    • Extension and rotation increase pain. In Spurling's manoeuvre, the patient's neck is extended, bent laterally, and held down. It elicits radicular symptoms.
    • The abduction sign is when pain improves when the neck is flexed or on abduction of the affected arm over the top of the head.
    • Upper limb weakness, paraesthesia, dermatomal sensory deficit and changes to reflexes can occur as outlined in the table below.[1] 
    • A herniated disc can also produce thermal changes (thermatomes) in specific distributions.
    Neurological features associated with cervical radiculopathy
    Nerve rootMuscle weaknessReflex changesSensory changes
    • Shoulder abduction and flexion
    • Elbow flexion
    • Biceps
    • Lateral arm
    • Elbow flexion
    • Wrist extension
    • Biceps
    • Supinator
    • Lateral forearm
    • Thumb
    • Index finger
    • Elbow extension
    • Wrist flexion
    • Finger extension
    • Triceps
    • Middle finger
    • Finger flexion
    • None
    • Medial side lower forearm
    • Ring and little fingers
    • Finger abduction and adduction
    • None
    • Medial side upper forearm
    • Lower arm
  • Signs of myelopathy on examination:
    • Increased upper and lower limb reflexes or other upper motor neurone signs suggest myelopathy.
    • Upper motor neurone signs include:
      • Weakness
      • Spasticity
      • Hyperreflexia
      • Positive Babinski's sign (up-going plantars)
      • Clonus
      • Positive Hoffman's reflex (flicking a finger causes adjacent fingers to flex)
    • Sphincter disturbances are late features of cervical and thoracic cord compression.
    • Cervical spine lesions can produce quadriplegia.
    • Urgent evaluation and action are needed.
  • It is easy to diagnose that pain originates from the neck but being sure that there is a disc lesion usually requires imaging studies.
  • Neck pain in the general population is common.[5] Most will not be a disc lesion.
  • Differential diagnoses include:
    • Degenerative disc disease/cervical spondylosis
    • Traumatic prolapsed intervertebral disc
    • Simple neck pain: acute neck strain, postural neck ache or whiplash
    • Headache
    • Referred pain - eg, from the shoulder
    • Malignancy: primary tumours, secondary deposits or myeloma
    • Infections: discitis, osteomyelitis or tuberculosis
    • Fibromyalgia
    • Vascular insufficiency
    • Psychogenic neck pain
    • Inflammatory disease: rheumatoid arthritis
    • Metabolic diseases: Paget's disease of bone, osteoporosis
Neck pain with radiculopathy and no red flag features usually does not require imaging studies or other special investigations, as it is likely to be self-limiting.[1] Immediate admission and decompression are required for myelopathy (spinal cord compression).
  • Blood tests may be guided by suggestions of other rheumatological pathology.
  • Imaging studies are important but they should be interpreted in the light of the clinical picture, as positive findings are quite common in people without any complaints.
    • Plain X-ray of the cervical spine may be used to evaluate chronic degenerative changes, metastatic disease, infection, spinal deformity, and stability. Interpretation is difficult because degenerative features are almost universal over the age of 35 years.
    • An MRI scan may be indicated if X-rays show no significant abnormality but symptoms are continuing. MRI should be performed to assess for an intervertebral disc herniation, with or without compressive, spondylotic osteophytes.[6] 
    • CT myelography may be considered if there are any contra-indications to MRI. [6] 
  • Electromyography may be helpful if it is unclear whether the patient has cervical radiculopathy or a nerve entrapment syndrome in the upper extremity. [7] 
  • Look for and treat any comorbidity.
  • Drug treatment:
    • Analgesia may relieve pain and help muscle spasm.
    • If pain is chronic and severe, analgesia may be enhanced by the addition of amitriptyline or gabapentin.
    • Diazepam for 3-7 days may be useful for people with severe muscle spasm.
  • Early mobilisation is important.
  • Physiotherapy including stabilisation exercises and posture training may be valuable.
  • Heat and massage may relieve muscle spasm.
  • Neck supports should be used for as short a time as possible, ie 2-4 days, and under supervision.
  • There is insufficient evidence to recommend manual therapies such as manipulation.
  • Surgery:
    • The finding of a disc lesion does not mean that surgery is indicated and in most cases conservative management is all that is needed. There may be spontaneous regression of a herniated disc.[8] 
    • If there are significant neurological abnormalities such as upper motor neurone signs in the limbs or bladder disturbance, surgical decompression is indicated.
    • Surgery may also be indicated in intractable pain.
  • If an intervertebral disc compresses the spinal cord, it can produce myelopathy with weakness, hyperreflexia, and neurogenic bowel and bladder dysfunction. There may be associated significant upper limb weakness or numbness as well as pain.
  • Beware of missing serious underlying disease including malignancy, infections producing abscesses and inflammatory conditions. Always be alert to red flags.
  • The prognosis for cervical radiculopathy is favourable: symptoms resolve in most people without surgical treatment.[6] 
  • Surgery also has good results but is indicated in only a minority. It is likely that the attitude of the patient to active rehabilitation is very important for a good result. However, the general prognosis for neck pain is not good and it is often chronic and persistent.

Further reading & references

  1. Neck pain - cervical radiculopathy; NICE CKS, January 2009 (UK access only)
  2. Neck pain - non-specific; NICE CKS, January 2009 (UK access only)
  3. Neck pain - acute torticollis; NICE CKS, January 2009 (UK access only)
  4. Neck pain - whiplash injury; NICE CKS, January 2009 (UK access only)
  5. Manchikanti L, Singh V, Datta S, et al; Comprehensive review of epidemiology, scope, and impact of spinal pain. Pain Physician. 2009 Jul-Aug;12(4):E35-70.
  6. Eubanks JD; Cervical radiculopathy: nonoperative management of neck pain and radicular symptoms. Am Fam Physician. 2010 Jan 1;81(1):33-40.
  7. Hakimi K, Spanier D; Electrodiagnosis of cervical radiculopathy. Phys Med Rehabil Clin N Am. 2013 Feb;24(1):1-12. doi: 10.1016/j.pmr.2012.08.012. Epub 2012 Oct 24.
  8. Kobayashi N, Asamoto S, Doi H, et al; Spontaneous regression of herniated cervical disc. Spine J. 2003 Mar-Apr;3(2):171-3.

Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.

Original Author:
Dr Michelle Wright
Current Version:
Peer Reviewer:
Dr John Cox
Document ID:
3899 (v25)
Last Checked:
Next Review:

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