Cold Injury

946 Users are discussing this topic

PatientPlus articles are written by UK doctors and are based on research evidence, UK and European Guidelines. They are designed for health professionals to use, so you may find the language more technical than the condition leaflets.

See also: Frostbite written for patients

The severity of cold injury depends on the temperature, duration of exposure, environmental conditions, amount of protective clothing, and the patient's general state of health. Exposure to cold can cause localised injury or generalised cooling of the entire body (see separate article on Hypothermia).

Susceptibility to cold injury is increased by any factor that can increase heat loss or decrease heat production:

  • Lower temperatures - especially windy conditions
  • Dehydration
  • Infancy, elderly age, malnutrition, exhaustion
  • Immobilisation - eg, fracture
  • Open wounds
  • Prolonged exposure
  • Moisture
  • Peripheral vascular disease
  • Impaired cerebral function: for example, alcohol, other sedatives, psychiatric illnesses, hypoglycaemia
  • Smoking, diabetes and Raynaud's disease increase risk due to vasoconstriction
  • Peripheral neuropathy, autonomic neuropathy, head injury, spinal cord damage
  • Body parts previously frostbitten are at increased risk due to damaged microcirculation

NEW - log your activity

  • Notes
    Add notes to any clinical page and create a reflective diary
  • Track
    Automatically track and log every page you have viewed
  • Print
    Print and export a summary to use in your appraisal
Click to find out more »

The initial response to the skin cooling is vasoconstriction. This is to help preserve core body temperature. This is followed by a cold-induced vasodilation which protects against cold injury at the cost of increased heat loss. This begins at about 10°C and the skin starts to lose sensation. With further cooling, blood viscosity increases and there is further vasoconstriction. At around -4°C, ice crystals will start to form in the extracellular space. During the freezing phase the body part will initially feel cold, then numb, with individuals describing clumsiness alongside anaesthesia. A simple classification can be used to describe the clinical effects:

  • Frostnip: the mildest form of cold injury. There is initial pain, pallor and numbness of the affected area. It is reversible with rewarming and does not result in any tissue loss, unless the injury is repeated over many years, which causes fat pad loss or atrophy.
  • Frostbite: freezing of the tissue with microvascular occlusion and subsequent tissue anoxia. Some of the tissue damage may result from reperfusion during rewarming. There is a four-tier classification in common use:
    • First-degree: hyperaemia and oedema without skin necrosis.
    • Second-degree: large clear vesicle formation in addition to hyperaemia and oedema with partial-thickness skin necrosis.
    • Third-degree: full thickness with subcutaneous tissue necrosis, often with haemorrhagic vesicles.
    • Fourth-degree: full thickness and subcutaneous tissue necrosis, also involving muscle and bone with gangrene.

A two-tier classification has also been described - superficial or deep frostbite. Superficial frostbite corresponds to first-degree and second-degree frostbite with no or minimal anticipated tissue loss. Deep frostbite corresponds with third-degree and fourth-degree injury where greater tissue loss will be anticipated.

  • Non-freezing injury:
    • Trench foot: non-freezing injury of the hands or feet resulting from chronic exposure to wet conditions and temperatures just above freezing.
    • The entire foot may appear black but deep tissue destruction may not be present. Progression to hyperaemia within 24 to 48 hours causes an intensely painful burning and dysaesthesia. Tissue damage causes oedema, blistering redness, bruising and ulceration.
    • Complications include local infection, cellulitis, lymphangitis or gangrene.
    • Proper attention to foot hygiene can prevent the occurrence of most such injuries.
  • Chilblains (also known as perniosis or pernio):[3] 
    • Localised inflammatory skin lesions on exposed extremities of the body which are precipitated by cold.
    • Chilblains can be classified as:
      • Acute: they develop within 12-24 hours after exposure to cold and last for 1-2 weeks.
      • Chronic: they occur with repeated exposure to cold, resulting in persistent lesions which can lead to subsequent scarring and atrophy.
    • They typically occur on the face, tibial surface, or dorsum of the hands or feet, areas poorly protected or chronically exposed to the environment.
    • There are pruritic, red-purple skin lesions (papules, macules, plaques, or nodules).
    • Continued exposure leads to ulcerative or haemorrhagic lesions which progress to scarring, fibrosis, or atrophy with itching replaced by tenderness and pain.
    • Careful protection from further exposure, and the use of anti-adrenergics or calcium-channel blockers is often helpful.

If there is a strong possibility that the affected tissue could re-freeze then it is safer to keep it frozen than for it to be actively thawed. There is significant damage to a limb that freezes again. However, most frostbite will thaw spontaneously and it should be allowed to do so - there should be no attempt to keep tissue deliberately below freezing temperatures. Early management of cold-injured patients includes:

  • Treat hypothermia (measure core temperature) and trauma.
  • Identify the type and extent of cold injury.
  • Remove jewellery or material that could constrict the body part.
  • Rapidly rewarm in water heated and maintained between 37-39°C until the area becomes soft and pliable. This could take 30 minutes. Allow passive thawing if rapid rewarming is not possible.
  • Give ibuprofen and other pain medication - opiates may be needed as rewarming can be painful.
  • Air dry the area - do not rub it at all.
  • Apply topical aloe vera cream or gel if available.
  • Protect from refreezing and any direct trauma. Use large, dry, bulky dressings and elevate the body part if possible.
  • Ensure the patient is rehydrated.
  • Avoid walking on a thawed lower limb (it may be acceptable if only the distal toes are affected).

Treatment in hospital (or some kind of field clinic) follows the same principles as the early management in the field. There are some additional measures that can be implemented and more definitive surgical care may be necessary. Additional areas to consider:

  • Tetanus prophylaxis.
  • Debridement - this may involve selective drainage of clear blisters. Haemorrhagic blisters should be left intact.
  • Systemic hydration with IV fluid.
  • Systemic antibiotics: reserved for identified infections. Tobacco, nicotine and other vasoconstrictive agents must be withheld. Weight-bearing is prohibited until oedema is resolved.
  • Thrombolytic therapy can be considered. This may be appropriate for deep frostbite where there is potentially significant morbidity. It should be used in the first 24 hours after thawing the affected tissue. Angiography can be used for pre-thrombolytic intervention and subsequent monitoring. Thrombolytic therapy should only be undertaken where intensive-care facilities exist.
  • An experienced surgeon should be involved to assess for interventions. As well as clinical examination, angiography and technetium 99m bone scan can be used to assess surgical margins.

After initial therapy there are some interventions that can be considered and may reduce long-term sequelae:

  • Hydrotherapy. There is no evidence that it improves outcomes but it may improve circulation and help with debridement.
  • Hospitalisation will usually be necessary to manage deep frostbite but individual factors would otherwise determine whether the cold injury could be managed on an outpatient basis.
  • Surgical treatment including amputation. Estimation of depth and extent of tissue damage is not usually accurate until demarcation is evident. This can take 1 to 3 months although investigations may help with assessment.
  • A multidisciplinary approach will help achieve better long-term functionality - eg, protective footwear and orthotics in cases of deep frostbite to the lower limb.
  • Sympathectomy is not recommended, as there is not enough evidence to support its use.
  • Hyperbaric oxygen therapy is not recommended due to insufficient evidence of any benefit.
  • When combined with hypothermia or wound-related sepsis, localised cold injuries may lead to death. Complications are more common in those with arterial or systemic disease.
  • Secondary wound infection.
  • Tetanus.
  • Fluid sequestration in damaged tissues and diuresis may cause volume depletion.
  • Hyperglycaemia, acidosis.[4]
  • Dysrhythmias.
  • Gangrene.
  • Possible long-term sequelae of cold injury include:
    • Paraesthesias and sensory deficits, tremor
    • Hyperhidrosis or anhidrosis
    • Cracking of skin and loss of nails
    • Permanent discolouration and/or scarring
    • Vasospasm, cold sensitivity
    • Joint stiffness
    • Premature closure of epiphyses in children; osteoporosis
    • Muscle atrophy

The prognosis depends on the severity and duration of the cold environment and the presence of any risk factors.

Further reading & references

  1. Zafren K; Frostbite: prevention and initial management. High Alt Med Biol. 2013 Mar;14(1):9-12. doi: 10.1089/ham.2012.1114.
  2. McIntosh SE, Hamonko M, Freer L, et al; Wilderness Medical Society practice guidelines for the prevention and treatment of frostbite. Wilderness Environ Med. 2011 Jun;22(2):156-66. doi: 10.1016/j.wem.2011.03.003.
  3. Almahameed A, Pinto DS; Pernio (chilblains). Curr Treat Options Cardiovasc Med. 2008 Apr;10(2):128-35.
  4. Biem J, Koehncke N, Classen D, et al; Out of the cold: management of hypothermia and frostbite. CMAJ. 2003 Feb 4;168(3):305-11.

Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.

Original Author:
Dr Colin Tidy
Current Version:
Peer Reviewer:
Dr Helen Huins
Document ID:
1977 (v22)
Last Checked:
Next Review:

Did you find this health information useful?

Yes No

Thank you for your feedback!

Subcribe to the Patient newsletter for healthcare and news updates.

We would love to hear your feedback!

Patient Access app - find out more Patient facebook page - Like our page