Polio and Polio Vaccination

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PatientPlus articles are written by UK doctors and are based on research evidence, UK and European Guidelines. They are designed for health professionals to use, so you may find the language more technical than the condition leaflets.

See also: Polio Immunisation written for patients
This disease is notifiable in the UK see NOIDs article for more detail.

Poliomyelitis (polio) is caused by infection with the poliovirus, an enterovirus. The virus may invade lymphatic tissue and spread into the bloodstream. It can be neurotropic, destroying motor neurons, particularly in the anterior horn of the spinal cord and brain stem. This causes flaccid paralysis which may be spinal or bulbar.

Polomyelitis causes a spectrum of illness from asymptomatic (most infections) to a meningitic or paralytic acute illness; the paralytic form can cause permanent muscle weakness. Acute polio infection is now rare in most countries following immunisation programmes. Polio survivors may have residual disability or post-polio syndrome.

'Wild' polio infection

  • The naturally occurring poliovirus is known as 'wild virus'. There are three subtypes of poliovirus; type 1 was the most common before vaccination was introduced.
  • The infection is transmitted by the faeco-oral route:
    • Infection is oral and the virus has high infectivity.
    • The virus multiplies in the oropharynx for 1-3 weeks. It is then excreted in saliva for a few days and in faeces for 2-3 weeks.
    • Most infections (95%) are mild, either asymptomatic or with a mild flu-like illness.
  • Since its launch in 1988, the World Health Organization's Global Polio Eradication Initiative has reduced worldwide polio incidence by over 99%. The most dramatic progress was achieved up to the year 2000 but subsequent years have seen only limited progress in preventing the last 1% of cases, particularly with continued endemicity in Pakistan and Afghanistan. There have, however, been recent gains in India and Nigeria.[2] 
  • There have also been recent cases elsewhere - eg, Syria.[3]
  • Risk factors for developing the paralytic form of infection (rather than mild illness) include physical activity and intramuscular injections.[4] The bulbar form of acute polio was more common in children who had undergone tonsillectomy and adenoidectomy.[1]

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Polio associated with vaccines[5]

Vaccine-associated paralytic polio (VAPP):

  • Rarely, the live attenuated vaccine virus in oral polio vaccine (OPV) can cause paralysis - either in the vaccinated child, or in a close contact. Immune deficiency of the recipient may contribute. This occurs in about 1 in 2.5 million doses of the vaccine.
  • It may affect either the vaccinated person or their contacts, because the vaccinated person excretes the virus.
  • Many countries, including the UK, are now using the inactive (injected) vaccine for this reason.
  • Vaccine-derived polioviruses (VDPVs): also rarely, a strain of poliovirus in OPV may genetically change so that it can both cause paralysis and circulate among a population.

With acute poliovirus infection, there are various clinical scenarios:

  • No symptoms, or flu-like illness ('abortive infection') - 95%.
  • Non-paralytic polio (flu-like symptoms plus aseptic meningitis) - about 4%.
  • Paralytic (with variable severity and recovery) - about 1%. Clinical features are:
    • Initially, a flu-like illness, then symptoms subside for a few days.
    • Symptoms then recur with myalgia, severe muscle spasms and meningism for a few days.
    • Next there is asymmetrical, flaccid motor paralysis, predominantly lower-limb. This maximises at 48 hours.
    • There is also a bulbar form of paralysis (about 10-25% of paralytic cases). This may cause autonomic features - eg, hyper/hypotension, respiratory failure, and bulbar symptoms, such as dysphagia and dysphonia.
  • Rarely, acute encephalitis can occur from poliovirus.
  • Serology: take acute and convalescent samples. A positive IgM or a four-fold increase in IgG is diagnostic.
  • The virus can be detected by polymerase chain reaction using samples from throat, stool or CSF.

Notification and contacts

  • For any suspected case of polio infection, report it immediately to a consultant in communicable diseases.
  • Household contacts require immediate polio vaccination. Other people in the neighbourhood may also require vaccination.
  • A supply of the appropriate vaccine will be issued on Public Health England advice.

Acute paralytic polio

  • Strict bed rest to prevent extension of the paralysis.
  • Supportive care - eg:
    • Prevent problems related to immobility - eg, pressure sores, constipation.
    • Analgesia.
    • A urinary catheter may be needed.
    • Acute respiratory failure can develop rapidly; the patient may need respiratory support and/or tracheostomy.


  • Prevent deformity by stretching exercises and splinting of affected limbs.


  • Intensive physiotherapy.
  • Orthoses and splints if needed.
  • Occupational therapy.

Early complications

Late complications and their prevention

Osteoporosis and osteomalacia:

  • Limbs which are less used or are non-weight-bearing are vulnerable to osteopenia.
  • Patients spending less time outdoors are at risk of vitamin D deficiency and osteomalacia, which can exacerbate bone and joint problems.

See the separate article on Post-polio syndrome:

  • This can occur years (or many years) after acute polio.
  • It comprises symptoms such as functional deterioration, fatigue and respiratory problems.
  • Prevention or amelioration of post-polio syndrome may be possible to some extent by:
    • Maximising support for the polio disability - eg, ensuring aids and orthoses are correctly fitting.
    • Avoiding overuse of muscles.
    • Detecting and treating problems early - eg, respiratory problems.
  • The milder spectrum of poliovirus infection (asymptomatic or flu-like illness only) carries no specific complications.
  • With paralytic polio, muscle function can return gradually, but there is some residual paralysis in the majority of survivors.
  • Mortality is higher in adults than in children and with bulbar poliomyelitis. Most deaths occur within the first two weeks.
  • There are two types of vaccine:
    • Inactivated: the Salk vaccine given by injection.
    • Live attenuated: the Sabin vaccine given orally. This parallels natural infection and has some advantages. However, with OPV there is a small risk of VAPP (see above).
  • In 2004 the UK switched from live attenuated OPV to inactivated polio vaccine (IPV) injections. OPV is no longer available for routine use.
  • The polio vaccine is now only given as part of combined products:
    • Diphtheria/tetanus/acellular pertussis/inactivated polio vaccine/Haemophilus influenzae type b (DTaP/IPV/Hib)
    • Diphtheria/tetanus/acellular pertussis/inactivated polio vaccine (DTaP/IPV, or dTaP/IPV)
    • Tetanus/diphtheria/inactivated polio vaccine (Td/IPV).
  • These vaccines are inactivated, do not contain live organisms and cannot cause the diseases against which they protect. IPV can therefore be given safely to people with immunosuppression (including those with HIV), and to pregnant and breast-feeding women.
  • Td/IPV vaccine should be used where protection is required against tetanus, diphtheria or polio in order to provide comprehensive, long-term protection against all three diseases.
  • Vaccines should be stored in the original packaging at +2˚C to +8˚C and protected from light.
  • The vaccines should not be given to those who have had:
    • A confirmed anaphylactic reaction to a previous dose of IPV-containing vaccine; or
    • A confirmed anaphylactic reaction to neomycin, streptomycin or polymyxin B (which may be present in trace amounts).

Immunisation schedules

 ChildrenAdults (who have not been immunised as a child)
Primary CourseThree doses of vaccine - as DTaP/IPV(polio)/Hib at two, three and four months of age.Three doses of vaccine - as Td/IPV(polio), each one month apart.
4th doseThree years after the primary course - as part of the DTaP/IPV(polio) pre-school booster at 3 years and four months to 5 years.5 years after the primary course - as Td/IPV(polio).
5th doseAged 13-18 years - the school leaver booster - as Td/IPV(polio).10 years after 4th dose - as Td/IPV(polio).

If the primary course is interrupted it should be resumed but not repeated, allowing an interval of one month between the remaining doses. Those who commenced vaccination with OPV can complete the course with IPV-containing vaccines.

Those born before 1962 may not have been immunised or may have received a low-potency polio vaccine.

All travellers to epidemic or endemic areas should ensure that they are fully immunised according to the UK schedule (see above). Additional doses of vaccines may be required according to the destination and the nature of travel intended.

Further reading & references

  1. Howard RS; Poliomyelitis and the postpolio syndrome. BMJ. 2005 Jun 4;330(7503):1314-8.
  2. Kew O; Reaching the last one per cent: progress and challenges in global polio eradication. Curr Opin Virol. 2012 Apr;2(2):188-98. doi: 10.1016/j.coviro.2012.02.006. Epub 2012 Mar 7.
  3. Poliomyelitis; Public Health England
  4. Narayan A, Ganesan S, Shenoy UV, et al; Provocative poliomyelitis causing postpolio residual paralysis among select communities of two remote villages of North Karnataka in India: a community survey. Indian J Public Health. 2011 Oct-Dec;55(4):309-12. doi: 10.4103/0019-557X.92412.
  5. Polio and prevention; Global Polio Eradication Initiative
  6. Immunisation against infectious disease - the Green Book (latest edition); Public Health England

Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.

Original Author:
Dr Colin Tidy
Current Version:
Peer Reviewer:
Dr Adrian Bonsall
Document ID:
662 (v24)
Last Checked:
Next Review:

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