Goserelin implant (Zoladex)

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Goserelin implants are injected under the surface of the skin on your stomach.

Each time you collect a prescription, check to make sure it looks the same as you have had before. There are two strengths of implant - Zoladex® 3.6 mg (suitable for men and women) and Zoladex® LA 10.8 mg (suitable for men only).

The most common side-effects are hot flushes, sweating, and reduced interest in sex.

Type of medicineA gonadorelin analogue (also known as an LHRH analogue)
Used forIn women: endometriosis; uterine fibroids; breast cancer; to thin the lining of the uterus before an operation; as part of a treatment for infertility
In men: prostate cancer
Also calledZoladex®; Zoladex® LA
Available asImplant, and long-acting implant (for men only)

Goserelin works by acting on the pituitary gland in your brain to stop the production of some of the sex hormones which your body makes naturally. It is given for a number of different conditions. It is used to treat some cancers - prostate cancer in men, and breast cancer in women. It is also given to women for some problems associated with the uterus (womb), and to help treat infertility.

Although it is unclear exactly why prostate or breast cancer develop, it is known that the sex hormones testosterone (in men) and oestrogen (in women) increase the growth of these cancers. Goserelin reduces the amount of these hormones, and this helps to stop the growth of the cancer cells.

In women, because it inhibits the production of female sex hormones, it is helpful in treating problems such as endometriosis and uterine fibroids. It is also given to prepare the uterus before some surgical operations. Goserelin also encourages ovulation in women, and it is for this reason it is used in infertility treatments.

Goserelin is contained in a small pellet which is implanted (like an injection) under the surface of the skin on your stomach.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you are given goserelin it is important that your doctor knows:

  • If you have low moods or are depressed.
  • If you have high blood pressure.
  • If you have diabetes mellitus (sugar diabetes).
  • If you have any vaginal bleeding for which you do not know the cause (that is, not your normal monthly period).
  • If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • If you have ever had an allergic reaction to a medicine.
  • Before you are given the implant, ask to read the printed information leaflet from the pack. The manufacturer's leaflet will give you information about the implant and will provide a full list of the side-effects which you may experience from it. If, as a result of reading the leaflet, you have any questions, please discuss them with your doctor/nurse before you have the implant.
  • The implant will be inserted for you by a person who has been specially trained. A very small pellet will be inserted just underneath the skin on your stomach.
  • Depending on the reason for your treatment, you may require further implants at 4-weekly, or 12-weekly, intervals. Remember to book your next appointment in plenty of time so that you receive the implant when it is due.
  • Try to keep your regular appointments with your doctor so that your progress can be monitored. If your doctor gives you a prescription so that you can collect the goserelin implant from the pharmacy, remember to take it with you for your appointment.
  • Goserelin can affect your blood sugar levels. If you have diabetes you may need to check your blood glucose more frequently. Your doctor will advise you about this.
  • Information for women: if you require contraception while you are on goserelin, use a barrier method such as a condom or diaphragm (cap). Do not use oral contraceptives ('the pill'). If you are using goserelin as a fertilisation treatment, you will already have had a test to show that you are not pregnant. You should not receive goserelin if you are pregnant, or think you might be pregnant.
  • Information for men: you may notice that your symptoms become worse when you first start treatment with goserelin and your doctor will give you some tablets to take during the first few weeks to help reduce this. Your symptoms should start to improve after a couple of weeks.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with goserelin. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Very common goserelin side-effects (these affect more than 1 in 10 people)
What can I do if I experience this?
Hot flushes, sweatingTake care not to become over-heated
Erectile dysfunction, reduced interest in sexSpeak with your doctor for advice
Headache (in women)Ask your doctor or pharmacist to recommend a suitable painkiller
Common goserelin side-effects (these affect less than 1 in 10 people)What can I do if I experience this?
Vaginal dryness or bleeding, acne (women), changes in breast size, depressed mood, tingling in the fingers or toes, skin rash, bone pain, reactions at the site of injection, decreased bone density, changes in blood pressure, weight changes, and an increased risk of heart attack (men)If you are concerned about any of these, speak with your doctor

Important: if you develop a skin rash or have any difficulties with your breathing, you should contact your doctor for advice straightaway. These are rare but possibly serious symptoms, as they may be signs of an allergic reaction.

If you notice any other problems which you think may be caused by the implant, speak with your pharmacist or doctor for advice.

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

If you buy any medicines, check with a pharmacist that they are suitable to take with your other medicines.

If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.

Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

If you have any questions about your medicines, ask your pharmacist.

Further reading & references

Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.

Original Author:
Helen Allen
Current Version:
Peer Reviewer:
Dr John Cox
Document ID:
3768 (v23)
Last Checked:
Next Review:
The Information Standard - certified member

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