Moclobemide (Manerix)

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Take your doses of moclobemide at the end of a meal, or after a snack.

Avoid eating large amounts of mature cheese, yeast extracts such as Marmite®, Oxo® and Bovril®, and soya bean extract.

Check with your pharmacist before you buy or take any other medicines. Some commonly used cough and cold remedies and some painkillers must not be taken with moclobemide.

Tell your doctor if you feel that you are not getting any better, or if you experience any troublesome side-effects.

Type of medicineA reversible inhibitor of monoamine oxidase type A (RIMA) antidepressant
Used forAdults with depression or social anxiety disorder
Also calledManerix®
Available asTablets

Moclobemide is prescribed for people with depression or social anxiety disorder, particularly if other treatments have proved unsuccessful.

Depression can develop for no apparent reason, or it can be triggered by a life event such as a relationship problem, a bereavement, or an illness. Social anxiety disorder is also known as social phobia - it is a fear of behaving in an embarrassing way whilst talking or meeting with other people.

Moclobemide works by interfering with brain chemicals, called neurotransmitters. It works by reducing the action of an enzyme called monoamine oxidase A. By doing this, it increases the levels of the neurotransmitters, serotonin, dopamine and noradrenaline. Altering the balance of these brain chemicals can help with the symptoms of depression and social anxiety disorder.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking moclobemide it is important that your doctor knows:

  • If you are pregnant, trying for a baby or breast-feeding.
  • If you have thyroid problems.
  • If you have any problems with the way your liver works.
  • If you have bipolar disorder or are feeling particularly agitated or confused.
  • If you have been told you have a tumour on your adrenal gland, called phaeochromocytoma.
  • If you have ever had an allergic reaction to a medicine.
  • If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack and any additional printed information you are given. The leaflets will give you more information about moclobemide and will provide you with a full list of the side-effects which you may experience from taking it.
  • Take moclobemide exactly as your doctor tells you to. It is usual to be prescribed two doses to take a day. You may be asked to take one or two tablets for each of your doses. There are two strengths of tablet available - 150 mg and 300 mg.
  • Take moclobemide with a meal, or just after a snack.
  • If you forget to take a dose, take it as soon as you remember (unless it is nearly time for your next dose, in which case leave out the missed dose). Do not take two doses together to make up for a forgotten dose.
  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.
  • Some people who take moclobemide can be sensitive to a substance called tyramine which is present in some foods and alcoholic drinks. You should avoid eating large amounts of food such as mature cheese, yeast extracts such as Marmite®, Oxo® and Bovril®, and fermented soya bean extract (an ingredient in some Chinese food).
  • When you first start taking moclobemide, you may have thoughts about harming yourself or ending your life. These thoughts can be associated with your condition. It is very important that you tell your doctor about this if it happens.
  • Continue to take moclobemide unless your doctor tells you otherwise. Stopping treatment suddenly can sometimes cause problems and your doctor will probably want you to reduce your dose gradually if this becomes necessary. Your doctor may ask you to carry on taking moclobemide even after you feel better. This is normal and helps to prevent your symptoms from recurring.
  • Check with a pharmacist before you buy or take any other medicines, to make sure that they are safe to take with moclobemide. Some commonly used cough and cold remedies and some painkillers must not be taken with moclobemide.
  • If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking moclobemide.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the ones associated with moclobemide. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Moclobemide side-effectsWhat can I do if I experience this?
Feeling dizzy, eyesight problemsDo not drive or use tools or machines if this happens
Dry mouthTry chewing sugar-free gum or sugar-free sweets
Feeling sick, diarrhoeaStick to simple foods. Drink plenty of water to replace the lost fluids
ConstipationTry to eat a well-balanced diet and drink plenty of water
HeadacheAsk your pharmacist to recommend a suitable painkiller. If the headache continues, speak with your doctor
Difficulty sleeping, feeling restless or irritable, tingling sensationsIf any of these become troublesome, speak with your doctor for advice
Allergic-type symptoms such as an itchy rash or swellingSpeak with your doctor straightaway

If you experience any other symptoms which you think may be due to the tablets, speak with your doctor or pharmacist for further advice.

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.

This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.

Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

If you have any questions about this medicine ask your pharmacist.

Further reading & references

  • Manufacturer's PIL, Manerix® 150 mg and 300 mg; Meda Pharmaceuticals, electronic Medicines Compendium. Dated November 2013.
  • British National Formulary; 67th Edition (March 2014) British Medical Association and Royal Pharmaceutical Society of Great Britain, London

Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.

Original Author:
Helen Allen
Current Version:
Peer Reviewer:
Dr John Cox
Document ID:
3470 (v24)
Last Checked:
Next Review:
The Information Standard - certified member

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