Azilsartan - an angiotensin receptor blocker (Edarbi)

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Take azilsartan once each day. You can take the tablets either before or after a meal.

Any side-effects are usually mild. They include feeling dizzy and having diarrhoea.

Keep your regular appointments with your doctor to have your blood pressure measured.

Some painkillers can interfere with azilsartan and increase the risk of side-effects, so ask a pharmacist for advice before you buy any medicines 'over the counter'.

Type of medicineAn angiotensin-II receptor antagonist
Used forHigh blood pressure
Also calledEdarbi®
Available asTablets

Azilsartan is an angiotensin receptor blocker. It is also called an angiotensin-II receptor antagonist, or an AIIRA. You will have been prescribed azilsartan because your blood pressure is too high (hypertension). People with high blood pressure often do not feel unwell but, if left untreated, high blood pressure can harm the heart and damage blood vessels.

Azilsartan works by blocking the effect of a substance in your body called angiotensin II. Angiotensin II causes your blood vessels to narrow, so by blocking its effect, azilsartan allows your blood vessels to relax and widen. As this happens, the pressure within your blood vessels is reduced.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking azilsartan it is important that your doctor knows:

  • If you are pregnant or breast-feeding.
  • If you have a problem with your kidneys, particularly if it is a blockage of the artery which supplies blood to your kidneys.
  • If you have any problems with your heart valves or heart muscle, or if you have a condition called heart failure.
  • If you have a problem with the way your liver works.
  • If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • If you have ever had an allergic reaction to a medicine, or if you have had any other type of allergic reaction.
  • Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about azilsartan and will provide you with a full list of the side-effects which you may experience from taking it.
  • Take azilsartan once each day, exactly as your doctor tells you to. There are several different strengths of tablet available (20 mg, 40 mg and 80 mg). When you first start treatment your doctor may gradually increase the strength of the tablets to suit your condition. Each time you collect a fresh supply of tablets, it's a good idea to check the strength on the packet to make sure they are what you are expecting.
  • Try to take azilsartan at the same time of day each day. For most people this will be in the morning. Taking your doses at the same time each day will help you to remember to take azilsartan regularly.
  • Swallow the tablet with a drink of water. You can take azilsartan either before or after a meal.
  • If you forget to take a dose, take it as soon as you remember. If you do not remember until the following day, miss out the forgotten dose. Do not take two doses at the same time to make up for a forgotten dose.
  • Try to keep your regular appointments with your doctor. This is so your progress can be monitored and your blood pressure measured. Your doctor may want you to have some blood tests from time to time to check on your kidneys, and also how much potassium is in your blood.
  • If you buy any medicines, check with a pharmacist that they are suitable to take with azilsartan. This is because some anti-inflammatory painkillers (such as aspirin and ibuprofen) can interfere with the way it works, and also may increase the risk of side-effects.
  • It is very important that you follow any dietary and lifestyle advice that you may have been given by your doctor, such as eating a healthy diet, not smoking, and taking regular exercise.
  • If you drink alcohol, ask your doctor for advice. Your doctor may recommend that you do not drink alcohol while you are on azilsartan because it will increase the risk of side-effects, such as feeling dizzy or faint.
  • Try to avoid salt substitutes which contain potassium. This is because the substitutes will increase the amount of potassium in your blood and this can cause problems.
  • If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking azilsartan. This is because your blood pressure may drop too low if you are given certain anaesthetics.
  • Treatment with azilsartan is usually long-term unless you experience an adverse effect. Continue to take the tablets regularly, unless you are advised otherwise by your doctor.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with azilsartan. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Common azilsartan side-effects (these affect less than 1 in 10 people)
What can I do if I experience this?
Feeling dizzy, particularly when you stand upGetting up and moving more slowly should help. If you begin to feel dizzy, sit for a few minutes before you stand up again
DiarrhoeaDrink plenty of water to replace lost fluids
Changes to the results of some blood testsYour doctor will check for this from time to time

If you experience any other symptoms which you think may be due to the tablets, speak with your doctor or pharmacist for further advice.

  • Keep all medicines out of the reach and sight of children.
  • Store in the original container in a cool, dry place, away from direct heat and light.

Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.

This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.

Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

If you have any questions about this medicine ask your pharmacist.

Further reading & references

  • Manufacturer's PIL, Edarbi® Tablets; Takeda UK Ltd, The electronic Medicines Compendium. Dated November 2014.
  • British National Formulary; 70th Edition (Sep 2015) British Medical Association and Royal Pharmaceutical Society of Great Britain, London

Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.

Original Author:
Helen Allen
Current Version:
Peer Reviewer:
Dr Adrian Bonsall
Document ID:
28445 (v2)
Last Checked:
17/02/2016
Next Review:
16/02/2019
The Information Standard - certified member

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