Indapamide tablets (Natrilix)

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Indapamide is prescribed for high blood pressure (hypertension).

It is best taken in the morning.

Any side-effects are usually mild. The most common are a skin rash, feeling sick, and feeling dizzy.

Type of medicineAn antihypertensive
Used forHigh blood pressure
Also calledStandard-release tablets: Natrilix®
Modified-release tablets: Cardide® SR; Indipam® XL; Natrilix SR®; Rawel® XL; Tensaid XL®
Combination brand: Coversyl® Arginine Plus (indapamide with perindopril)
Available asTablets and modified-release tablets

Indapamide is prescribed for the treatment of high blood pressure (hypertension). Although it belongs to a group of medicines called diuretics (which generally work by making the kidneys pass more urine out of the body), at the doses prescribed for hypertension, indapamide is considered to work by widening (dilating) blood vessels. By widening the blood vessels, it reduces the pressure inside the blood vessels and over time this leads to a lowering of high blood pressure.

Indapamide is available as standard tablets and also as modified-release tablets. Both forms of tablet are taken just once daily. The modified-release tablets have letters such as 'XL' or 'SR' after their brand name. Modified-release tablets release indapamide more slowly over the day than the standard tablets do.

Indapamide can be used as a treatment for high blood pressure on its own, or it can be prescribed in combination with other medicines which reduce blood pressure.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking indapamide it is important that your doctor knows:

  • If you are pregnant or breast-feeding.
  • If you have any problems with the way your liver works, or any problems with the way your kidneys work.
  • If you have gout, diabetes or an inflammatory condition called systemic lupus erythematosus (also called lupus, or SLE). These conditions can be made worse by medicines like indapamide.
  • If you have been told by a doctor that you have low sodium or potassium levels in your blood, or high calcium levels in your blood.
  • If you have a problem with your adrenal glands, called Addison's disease.
  • If you have a rare inherited blood disorder called porphyria.
  • If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • If you have ever had an allergic reaction to a medicine. It is particularly important that you tell your doctor if you have had an unusual reaction to a medicine known as a 'sulfonamide'.
  • Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about indapamide and will provide you with a full list of the side-effects which you may experience from taking it.
  • Take indapamide exactly as your doctor tells you to. The usual dose is one tablet daily. Your doctor is likely to recommend that you take the tablet in the morning.
  • Swallow the tablet with a drink of water. You can take it either before or after a meal.
  • If you have been prescribed a modified-release tablet (these have 'SR' or 'XL' after the brand name), these tablets should be swallowed whole. Do not break, crush or chew them.
  • If you forget to take a dose, take it as soon as you remember. However, if it is after 6 pm, you should skip the forgotten dose and take your next dose as usual on the following day. Do not take two doses on the same day to make up for a missed dose.
  • Treatment for high blood pressure (hypertension) is usually long-term. Although many people with high blood pressure do not feel unwell, if left untreated, high blood pressure can harm your heart and damage your blood vessels. This damage may later result in a heart attack, stroke, or kidney problems, so it is important that you continue to take these tablets regularly to help reduce the risk of this.
  • Try to keep your regular appointments with your doctor. This is so your doctor can monitor your blood pressure and check on your progress. Also, the salt balance in your bloodstream may be upset by indapamide and your doctor may want you to have a blood test from time to time to check for this.
  • You may be given some lifestyle or dietary advice by your doctor, such as stopping smoking, reducing the amount of salt in your diet and taking some regular exercise. Following this advice will also help to reduce the risk of damage to your heart and blood vessels.
  • Drinking alcohol while you are on indapamide may make you feel dizzy. Ask for your doctor's advice about whether you should avoid alcohol.
  • If you are due to have an operation or dental treatment, you should tell the person carrying out the treatment which medicines you are taking.
  • If you are an athlete, please be aware that indapamide may give a positive reaction in doping tests.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with indapamide. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Common indapamide side-effects (these affect less than 1 in 10 people)
What can I do if I experience this?
A rash, or an increased sensitivity to sunlightSpeak with your doctor for advice as your treatment may need to be reviewed
Less common indapamide side-effects
(these affect less than 1 in 100 people)
What can I do if I experience this?
Feeling or being sick, stomach upsetStick to simple foods - avoid rich or spicy meals. Try taking the tablet after a meal if you are not already doing so
Feeling dizzy, particularly when you stand up (due to low blood pressure)Getting up more slowly should help. Do not drive or use tools or machines until you feel better

If you experience any other symptoms which you think may be due to the tablets, speak with your doctor or pharmacist for further advice.

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.

This medicine is for you. Do not give it to other people even if their condition appears to be the same as yours.

If you buy any medicines, check with a pharmacist that they are suitable to take with your other medicines.

Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

If you have any questions about this medicine ask your pharmacist.

Further reading & references

  • Manufacturer's PIL, Natrilix®; Servier Laboratories Limited, The electronic Medicines Compendium. Dated May 2014.
  • British National Formulary; 69th Edition (Mar 2015) British Medical Association and Royal Pharmaceutical Society of Great Britain, London

Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.

Original Author:
Helen Allen
Current Version:
Peer Reviewer:
Dr Hayley Willacy
Document ID:
3296 (v28)
Last Checked:
13/05/2015
Next Review:
12/05/2018
The Information Standard - certified member

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