Oestrogen and Progestogen for HRT

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HRT is used to help relieve menopausal symptoms.

If you are not sure how to take or use the preparation you have been given, ask your pharmacist to explain it for you.

Side-effects are usually mild.

Type of medicineFemale sex hormones
Used forHormone replacement therapy (HRT)
Also calledTablets: Angeliq®; Climesse®; Clinorette®; Cyclo-Progynova®; Elleste Duet®; Elleste Duet Conti®; Femoston®; Femoston-conti®; Indivina®; Kliofem®; Kliovance®; Novofem®; Nuvelle Continuous®; Premique®; Prempak-C®; Tridestra®; Trisequens®
Patches: Estragest TTS®; Evorel Conti®; FemSeven Conti®; FemSeven Sequi®; Nuvelle TS®
Available asTablets and patches

Most hormone replacement therapy (HRT) is a combination of two female hormones, an 'oestrogen' and a 'progestogen'. Oestrogens and progestogens are natural female hormones which are used to treat women's health problems, including menopausal symptoms. Different types of oestrogen and progestogen are used in HRT products. The oestrogens used include conjugated oestrogens, estradiol, estriol and estrone. The progestogens used include medroxyprogesterone, norgestrel, drospirenone, norethisterone, dydrogesterone, and levonorgestrel. You will find the names of the oestrogen and progestogen used in your HRT on the labelling of the package. HRT is available as tablets and as patches to be applied to your skin. There are several brands for each of these types of HRT - all deliver a set dose of oestrogen and progestogen into your bloodstream.

During the menopause, or 'change', your natural female hormone levels begin to fall. HRT replaces these hormones. The oestrogen helps to relieve some of the problems associated with the menopause, such as hot flushes, night sweats and vaginal dryness. The progestogen protects the lining of your womb (uterus). Depending on the preparation you are using, you may take the progestogen daily or for only part of the month.

HRT also protects against osteoporosis, although other treatments are often preferred for this. Osteoporosis weakens your bones, making breaks and fractures more likely.

If you have had your uterus removed during surgery (a hysterectomy), then you will only need to take oestrogen HRT. Please see the separate leaflet called Oestrogen HRT for more information about this.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking HRT it is important that your doctor knows:

  • If you have migraine-like headaches.
  • If you have any unexplained vaginal bleeding.
  • If you have had breast cancer or any lumps in your breast, or if a close family member has had breast cancer.
  • If you or a close family member have ever had a blood clot in the legs or lungs.
  • If you have a problem with your veins (such as thrombophlebitis).
  • If you have too much sugar in your blood (diabetes mellitus), epilepsy, or asthma.
  • If you have liver, kidney, or gallbladder problems.
  • If you have ever had depression.
  • If you have high blood pressure or a heart disorder.
  • If you have chest pain (angina) or if you have had a heart attack.
  • If during a pregnancy you have had problems such as severe itching and blistering of your skin, yellowing of your skin or the whites of your eyes (jaundice), or any involuntary jerky movements.
  • If you have a rare inherited blood disorder known as porphyria.
  • If you have ever had an allergic reaction to a medicine.
  • If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
  • Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. The leaflet will give you more information about the specific brand of HRT you have been given, and a full list of possible side-effects from taking it.
  • If you have been prescribed tablets: follow the instructions on your pack - it is usual to take one tablet every day:
    • Some brands may have different coloured tablets to take on certain days; other brands may contain a second tablet for you to take on certain days of the month. If you are unsure what to do, ask your pharmacist for advice.
    • Take the tablet at the same time of day each day. If you forget to take a dose, read the advice on the manufacturer's leaflet and follow the instructions it gives. You can take the tablets before, during or after your meals.
  • If you have been prescribed patches: some patches are applied and left on for a whole week (such as FemSeven®), whereas with others you apply two patches during a week (each is removed after 3-4 days). Make sure you are clear about how often to use the patches you have been prescribed - the instructions for how to use them will be on the label of the pack.
    • Apply the patches to clean, dry, unbroken areas of your skin, preferably below your waist. You should not apply the patches near to your breasts. Each time you use a patch, apply it to a different area so that your skin doesn't become irritated.
    • There are several different types of patches, so it is a good idea to check that you have the same patches each time you collect a prescription.
    • With some patches, you will also be given tablets to take on certain days of the month. Read the instructions carefully and if you are not sure when to start taking the tablets, ask your pharmacist for advice.
  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. Also, regularly check your breasts for any lumps and go for regular breast screening and cervical smear tests.
  • If you are due to have an operation, tell the person carrying out the surgery that you are taking HRT, as you may be advised to stop the treatment for a while if you are likely to be on bed rest.
  • There are some risks which are associated with HRT - your doctor will discuss the benefits and risks of the treatment with you before you start. The risks are reduced when small doses of HRT are used for short periods of time. If used for a long time the risk of breast cancer and other complications may increase. Because of this, the decision to continue HRT needs to be made individually and your progress should be reviewed at least once a year. If you have any concerns at any time, make an appointment to discuss them with your doctor.
  • Travelling that involves long periods of immobility (more than three hours) can increase the risk of serious side-effects and, in rare cases, may lead to blood clots. Taking appropriate exercise during the journey and possibly wearing elastic hosiery can reduce this risk. If you would like more advice about this, speak with your doctor or pharmacist.
  • HRT treatments are not suitable for preventing pregnancy. If you are having menstrual periods (and for 1-2 years afterwards) you could still become pregnant. You should not take the contraceptive pill while you are on HRT - you are advised to use other methods of contraception such as condoms or a cap. Do not use the rhythm method, as your usual menstrual cycle will become less regular during the menopause and make this method unreliable. If you suspect you might be pregnant, stop taking HRT and speak with your doctor as soon as possible.
  • If you pay for your prescriptions and your pack contains more than one type of tablet or patch then you may need to pay two prescription charges.
  • If you have diabetes you may need to test your blood more frequently, as the HRT may affect the levels of sugar in your blood. Your doctor will be able to advise you about this.
  • Before buying any medicines, check with your pharmacist which medicines are safe for you to take alongside HRT.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. These usually improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.

Common HRT side-effectsWhat can I do if I experience this?
Feeling or being sickEat simple meals (avoid rich or spicy foods)
HeadacheAsk your pharmacist to recommend a suitable painkiller. If the headache continues or is unusually severe, speak to your doctor as soon as possible
Feeling dizzyGetting up or moving more slowly should help. Do not drive if you feel dizzy
Dry eyesIf this becomes troublesome 'artificial tears' can be purchased from pharmacies. If you wear contact lenses, ask your optician for advice
Irregular menstrual bleedingYou may have some irregular bleeding in the first few months of taking HRT. If it happens later on, speak with your doctor
Stomach cramps, bloating, weight changes, breast tenderness, fluid retention, itchy skin rash, acne, changes in sexual desire, mood changes, leg cramps, hair thinning. Speak with your doctor if any of these become troublesome
Patches causing skin irritationEach time you change the patch apply it to a different area of skin, following the manufacturer's instructions. If irritation continues speak to your doctor or pharmacist

Stop taking HRT and contact your doctor for advice straightaway if you develop any of the following symptoms:

  • Sudden chest pain.
  • Sudden breathlessness, or if you cough up blood.
  • Swelling or pain in a leg.
  • An unusually severe headache.
  • Yellowing of your skin or the whites of your eyes (jaundice).

If you experience any other symptoms which you think may be due to this medicine, discuss them with your doctor or pharmacist.

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.

This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.

Never keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

If you have any questions about this medicine ask your pharmacist.

Further reading & references

  • British National Formulary; 71st Edition (Mar-Sep 2016) British Medical Association and Royal Pharmaceutical Society of Great Britain, London

Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.

Original Author:
Helen Allen
Current Version:
Peer Reviewer:
Dr Helen Huins
Document ID:
3860 (v26)
Last Checked:
Next Review:
The Information Standard - certified member

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