375mg Venlafaxine and 30mg Mirtazapine

U may get used to it but if still the same in few days try half or c ur dr good luck x

It's normal. Mirtazapine can make you very drowsy. Especially when first starting it. It knocked me out and I have a very high tolerance to sedatives. Though I would of thought you should of been started at 15 mg of mirtazapine.  Though I have known the starting dose to be 30mg. It isn't unusual. The other thing is, its' more sedating the lower the dose, instead of tje other way around which could be why you were started on 30mg. Mirtazapine can make you feel very groggy and hungover to start with and can make you feel like you are dragging your legs through mud. You do adjust to it. But if you feel it is too much then speak to you r doctor.  Mirtazapine is a very good drug for severe depression. It tends to work within 2 weeks for a lot of people. It really helped lift my mood.

Thank you Lisa and Stardust. I will take your advice and  see how I go, and contact my Doctor if it doesn't improve.

To continue was stardust79 had said, Mirtazapine is a strange "less-is-more" type medication, where the 15mg does is more sedating, while the 30mg is more energizing and won't put you out.  Mirtazapine was the first med my doc has perscribed to me that did NOT give me absolutely BRUTAL side effects, like Lexapro and Effexor did.  I have been on it for exactly a month and I am not going to say I am "walking on sunshine" by any means, but I feel different, and I don't feel bad, so I think different is a good sign, people who have been depressed for so long don't even know what happiness feels like, so when the happiness returns, it will manifest itself with feelings of just feeling different at first, since you aren't used to it, and as time goes by, true joy that you can identify should start to finally show itself.  So different is good if thats what your med is doing, so long as you feel fine.  So remember all this.

Actually the fiirst time I took 30mg I fainted before my wife. Unbelievable.

Roxi I don’t know what Venlafaxine is, but my Dr. started me off on 15mg of Mirtazapine and worked me up to a maximum dose of 45mg on a time scale. I can’t tell you what to do, but you may want to contact your doctor and tell him/her what happened if this continues. Age and weight might also be a factor.

Don't read negatives about Mirtazapine. See how you go. If in the next 2 days you still feel yucky, go back to the doctor and maybe lower the dose. As with all drugs you do need to give it time for your body and brain to adjust and for the drug to work. We are all different.  We all have different reactions to drugs as to what others may or may not have. Mirtazapine is definitely a drug that will knock you out for a few weeks until you get used to it. Also makes you groggy for a few weeks. I've been on it for 2 and a half years and it's really helped me a long with clomipramine another anti depressant. I found when I was first on mirtazapine and at the time I was also on fluoxetine I did actually feel unusually happy after 10 days. Then slumped down again but then found I felt more normal after 4 weeks. Obviously with a new drug you go through the horrible waiting game of side effects and worrying and the whole will it work. Any antidepressant can sometimes make you feel worse before you feel better. But you should be monitored by your doctor during this time. But also if you feel something isn't right then there is no harm at all going back to your doctor and saying how you feel.

i was on mirtazipe 20 mls for two mnths did not help me at all in fact the opposite to u cudnt sleeo at all gud luk maybe the combination ov bothe drugs as made u sleep