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Certain painkillers may increase free thyroid hormone levels

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Recently, I stumbled upon the fact that certain nonsteroidal anti-inflammatory drugs (NSAIDs) notably Aspirin may lead to decreased protein binding of the thyroid hormones Thyroxine (T4) and Triiodothyronine (T3). 

You may know that only 0.3% of T4 and 0.03% of T3 in the blood plasma is in its active form that is unbound or free, hence the notation FT4 and FT3. 

Aspirin and possibly other common NSAID painkillers (ask your doctor or pharmacist) are not recommended for patients with overt hyperthyroidism as they can free up additional bound thyroid hormone thus (temporarily) increasing the amount of active thyroid hormone and potentially aggravating your symptoms. 

I came across this info while reading an article about the management of hyperthyroid patients with dental emergencies. It is important to let your dentist know if you are hyperthyroid before having dental treatment as you may need special management (extra caution with anaesthesia, different painkillers) in order to minimise the risk of complications. 

 

0 likes, 2 replies

2 Replies

  • vera40589
    vera40589 Guest

    Posted

    Hi Dan,

    Thank you for letting me know.

    I do not take any Nsaid or any painkiller

    Currrently. I think my endo overdosed my MMI. That is why I feel awful.

    Vera

  • linda187
    linda187 Guest

    Posted

    Great information Dan.  Thank you for posting it.
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