Coming off mirtazapine

Posted , 11 users are following.

I thought I would start a new thread to give people tips for coming off this drug. I have gained so much advice and support from people on here and I owe my (so far) painless withdrawal to them. People like Calmer and Betsy, and plenty others too. I have been on 30mg mirtazapine for four years. I tried to come off them a couple of years ago and failed miserably, returning to my full dose after 10 days of awful anxiety and insomnia, as well as migraines and nausea. I had cut my dose to 15mg for a week and then dropped to zero.

This time I read every thread on here about mirtazapine withdrawal and started off really slowly, cutting down by just 3.75mg for two weeks. Then by a further 3.75 mg. At the same time I started taking a lot of inositol. I take a huge heaped teaspoon in my tea every morning. I had only slight nausea when I first started dropping my dose but I think that was me getting used to the inositol. Once I was down to 22.5mg of mirt, with no withdrawal symptoms, I figured I could go a bit faster and dropped my dose down to 15mg. I had no withdrawal symptoms after ten days and so have now dropped my dose to 11.25mg. I use a simple pill cutter from ebay to cut my tablets. So I am now on three quarters of a 15mg tablet. Mirtazapine had pooped out on me and so I already have terrible insomnia. I take temazepam some nights and benadryl on others to help me with that.

I will post my progress here. Who knows, I may fail miserably, but whatever the outcome, I hope it will help others. I was terrified of coming off mirtazapine, but now I am excited by it. I think the key is to take it really slowly and work out the pace your body can cope with. The smaller your dose goes, thee smaller the decrease in your dose should be. Good luck everyone, and please post your own experiences here. I know some people have really suffered despite coming off mirt very slowly. Everyone is different and I think everyone's experience can be a real help to others.

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  • Posted

    Day three of 5.6mg and feeling good. Although I ate far too much last night and have paid for it on the scales this morning. My taste for alcohol is still very poor, but I managed to have three glasses of champagne last night. I did enjoy the first glass, but only drank the other two to be sociable. I was on the soft drinks by 10pm. Part of me is pleased about this sudden dislike of alcohol, but part of me wonders why it is. Could it be withdrawal, or something else? It's just so odd.
    • Posted

      Hi Evergreen

      It's probably the Mirt', I cannot tolerate alcohol very well now and kind of dread having to be in a situation where I've got to drink for a long period of time ... gone are the days when it was a large G&T whilst getting ready to go out !!

      I've always suffered quite badly with hangovers, more than my fair share I'd say, I even used to get the shakes with anxiety the day after!

      Perhaps the taste for it will come back for you on once you're off Mirt', but in a way, you might prefer to be sober, and might even sleep better yayyyyyyyyy smile

       

    • Posted

      Sleeping better would be great, although I don't hold out much hope. When I first went on mirtazapine, I avoided alcohol until I was sure how it would affect me, but after I had been on it for three years, my alcohol consumption had crept up to 2-3 glasses of wine almost every day. Only when I went on a diet and had to be a taxi at night for my son did I cut back. But I missed it and enjoyed the days I could still drink. However now I sort of want a drink but as soon as I imagine having one, I am turned off. But over all, I am glad. Probably it's a very good thing.
    • Posted

      Evergreen, you might want to go look on the forum Surviving Antidepressants and see what others are saying about their experiences.  I have seen lots of reference to people developing an intolerance to things like sugar, caffiene, alcohol, certain supplements and over-the-counter meds when in withdrawal.  I myself haven't developed any sensitivities that I can identify, but then I'm not the best at actually paying attention to my body ;-)  I have found myself only drinking part of the wine I have poured in recent days, and I have also found that less affects me more strongly.  A smaller amount makes be feel outright tipsy than in the past, talking like half a glass!
  • Posted

    Day five on 5.6mg and still feeling very stable. Yesterday I had a headache which had to be kept at bay with paracetamol, but so far no headache today. The last two evenings I have had painful wind, and last night a bit of nausea, but nothing to write home about. They are symptoms I have had on and off before withdrawing, so probably not due to the taper. My sleep is still very poor, so no news there. But overall, I feel very good. I plan to stay on this dose for another five days, and provided I do not suffer withdrawals, I will drop to 3.75mg.

    How is everyone else doing?

  • Posted

    Well themirt is still affecting my weight. I have been eating the amount I used to eat before going on mirt; not over-eating by any stretch of the imagination, just eating three normal meals and having a small snack. Around 2000 calories. I have put on two pounds in weight. It is less than I would have put on had I been on the full amount of mirt, but it just shows how much of an effect even the smallest dose of the stuff has on your weight.

    I am planning to take one more dosage of 5.6mg tonight and then drop my dose to 3.75mg. This is only seven days on 5.6mg, but I figure, since I had no withdrawals at all this time, not even a day of nausea, that I'm ready. Fingers crossed!

  • Posted

    Well I had a bad day today.  Its day 8 off the Mirt and I was having problems with morning.  I'm finding as soon as I wake up properly ( I wake about three times in the night) I have to get straight up as I start thinking about anxiaty and get anxiuos waiting to get anxious.  I'm sure some of you know what I mean.  Anyway I got up and if I go and do some work on my PC it helps take my mind off things and calms me down. Today took longer than normal and everytime I stopped being busy I started to get hot and sweaty.  I had a doctors appointment today to discuss my medication so at least I was taking comfort in that, which helped calm me down and reading on here about the CBT methods of self help which I have to find again as my dam PC crashed loosing the website also helped calm me.  Anyway off I trotted to the doctor wanting to discuss my withdrawal from the Mirts and the withdrawal symptom.  I choose the only doc at the practice that seems to listen to me as I have had some crap doctors and specialist that seem to just want you drugged up on horse sleeping pills so they can put a tick in a box and move on to the next customer.  Anyway when I got there she took my blood pressure and point blankly refused to discuss my Mirts withdrawal symptoms as she hadn't put me on  them and according to the surgery records I had only just started taking them this week.  I had 6 different boxes of pills with me that I had been prescribed by different doctors at my surgery and only two where down on record as being prescribed.  So I came away very unhappy and no wiser.  I was thinking of taking 1mg of Mirts to try and help with with the withdrawl effects it that would help.  I now have to wait till the 13th Jan to see the doc that put me on Mirts.  Dam usless NHS.
    • Posted

      Hi si675, 

      Wow, that's pretty bad that they don't have all your meds on record!

      What was the dose you jumped off of?  I'm assuming you are working with liquid mirt?  Lucky you!  I would say you would be safe to reinstate the 1 mg, and once you are stable, you might work on doing a dilution of your liquid mirt so that you can take 0.9 mg on your next cut.  I know it seems crazy, but I've seen some people suffer horribly for doing too large of cuts down at that very low end.  One guy went from 5.5to 4.5 mg, about 20%, and went in to such bad withdrawal that he reinstated to 5.5 mg, but it didn't help!  Hopefully, 1 mg will help you, and then a very gradual taper from there to slide off gently would be advised :-)

      Might I encourage you to join the support forum listed in the topic "Reducing ADs using a 10% withdrawal method" in the following link?

      https://patient.info/forums/discuss/depression-resources-298570

      It helps others to see your story, and you can be advised by folks who are very experienced in the finer details of tapering and withdrawal.  No cost, non-profit.  

    • Posted

      Hi Betsy,

      I think the NHS in the UK is really going down hill and when they build another 270 house in our village the poor little surgery we have wont be able to cope at all.

      I'm beginning to think the docs have given up on me as they have tried me on everything and nothing works.  I think you said in another post on here that I may be one of the unlucky ones that dont absorbed these types of meds and I should try the CBT self help which I am doing.  Step one is to identify whats causing the problem.  I'm still stuck at step one as I don't know whats causing the problem.

      Anyway back to the me coming off Mirt.  I was on 15mg for 5 weeks and the doc suggested I go up to two 15mg a day one in the morning one at night.  This made me feel worse so I tried half a dose.  Just bite the tablet in half method and that made me feel top of the world for 4 days then a bit of anxiaty crept in and I took a valium to calm down.  I think it was my body saying just stop this stuff all together so i did.  Four days of pure bliss.  Felt great.  Then back to waking in the morning waiting for the feelings to come on and because i was waiting and thinking about it they came on.  So I have to get up and get on the PC to take my mind off things. So I went from 15mg to 7.5mg to nothing.  I do feel so much better and feel the old me is coming back but its slow and hard.

    • Posted

      Anxiety is a self-perpetuating beast!  The more you worry about the anxiety, the more anxiety you have!  Did you always have anxiety, or is this something new for you?  

      You may be experiencing morning anxiety caused by cortisol rushes.  What time do you wake, and do you wake with a jolt?  Is it just getting light out?  There are some things you can do for "sleep hygiene," like blocking all light coming to your eyes when you sleep.  Even cutting down on computer/tv viewing before bed (blue light) can be necessary.  Block any lights, such as computer routers and the like.  We had one that just glared in the night in our room so I had to cover it.  Some folks use a sleep mask to block the eyes, while others use the black-out curtains.

      Many find magnesium helpful.  I take 500 mg of magnesium glycinate twice a day, especially at bedtime.  Sorry if I'm being redundant!  Also, inositol can be helpful, 15 mg of powder mixed in just about anything; it's sweet.

      There is a calming technique that uses acupressure points, called Emotional Freedom Techniques, also known as tapping.  This can help with anxiety and with falling back asleep.  Sometimes it takes me three rounds of tapping but I do fall back asleep after that.

    • Posted

      Sounds like you are having a really bad time. Jumping off from 7.5mg is quite a big shock for your body, although, as you've only been on the mirt for 5 weeks, it does seem excessive to be withdrawal symptoms. Could it be that the mirt was working and the anxiety is your own state of mind? Was it like that before going on the mirt?

      I too am trying to be drug free. The mirt worked well for a long time but then stopped working so I am coming off it. Tonight I cut down to 3.75mg from 5.6.

      I have found inositol (aka vitamin 8) powder to helf a huge amount. It really lifts my spirits. My husband who has never taken any psych drugs and who is very anti them, has found inositol has helped him hugely. I have noticed he is far less bad tempered and stressed. I forgot to put it in his tea this morning so we shall see if he feels it! We take a huge heaped teaspoon every day. You have to take 12-18grams for it to be theraputic.

    • Posted

      I do believe I was wrongly put on these drugs.  I went to the doctors with chest pains and no energy.  Never had a panic attack or felt anxieous till 4 days into my original meds Sertraline.  I was waking in the middle of the night in a right scarred state.  Mind going crazy and it just wouldnt shut off playing a song that I hated from 1989!  This was three days before I went on holiday and was having negative thoughts about not being able to get in the taxi, freaking out on the plane etc.  We managed to get on holiday after me staying awake for 3 days to stop the panic attacs as they happen mainly in the night.  But when I got there I had a bad panic attack and ended up in hospital for 3 days on valium. Thats good stuff and worked a treat.  Then back in the UK i got swapped about on differnt drugs and after finding out the SSRI family of drugs dont suite me I was put on Mirt and things just got worse.
    • Posted

      Ah, yes, obviously psych drugs don't agree with you and created the symptoms they are supposed to prevent. That is a rare but very real reaction which is why they can actually increase the likelihood of someone committing suicide. In your case then, reinstating any dose is probably inadvisable. I hope that you start to feel better soon. Have you tried magnesium or inositol? Both have a good calming effect.
    • Posted

      Yes I'm beginning to think that too.  I'm paying to gp private now and see a specialist who will help me work through my head issues.  I have tried herbal remadies but not mannesium or inositol  Will have a look in Holland & Barrett for some, thank you
    • Posted

      Betsy, do you mean 15mg or 15 grams? Theraputic amount of inositol is 12grams or more. I don't weigh it now just use a really big heaped teaspoon (or two if I'm feeling delicate that day).
    • Posted

      Meant to add for the OP - don't buy the capsules as you need to take many more than the instructions for a theraputic amount and will end up taking loads and it costing more. The powder is the most economical to get the amount you need for it to be effective against anxiety. The instructions always tell you to take a minute amount and not to exceed the dosage, but in the case of inositol, it is fine to take 12 - 18 grams without doing harm, though it does give you wind until you get used to it!
    • Posted

      So to chime ... that should read 0.09ml  liquid Mirt should anyone need to know - ,

      0.9 being equivalent to 13.5 mgs

      1ml = 15 mgs.

      Sorry ... just saying x

       

    • Posted

      Hi Si, Betsy, Evergreen,

      You know I've spent time looking at Si's history, and there is a typical picture of Mirt' withdrawal.  

      Si was taking 15 mg for 4 weeks (did you feel ok on this dose Simon????) and then his doctor said to double the dose by taking 15mg in the morning, and also 15mg in the evening). (this often causes a wobble). This is the base line before Si tried to quit.

      Before deciding to quit Si introduced Venbladex was it (?) to the mix which then caused breathing problems & further anxiety and therefore persuaded Si to quit 'everything'.

      Si then went quickly from 30 mg Mirt to 15 mg Mirt to 7.5 Mirt  FOR 7 DAYS THEN STOPPED.  Si has now been off for what is it - 8 days maybe.

      With understanding and compassion, I am trying to help here Si, I would keep a journal Si so that you get the true picture from here.

      If you wanted to reinstate Mirt, I don't think 1mg is going to hit the spot do you ladies ?? We can't really advise the usual to "consult with your doc also" as an experienced, helpful GP or even a P.doc isn't around (ggrrrr) 

      In my humble opinion, as Si was on 15mg for 4 weeks before the mix and swapping doses, only 15 mg is going to settle him.  

      I know you said Si that you felt anxiety only started once on Mirt' - but reading your story it seems that the anx' was at 2 x 15mg, or am I wrong?

      Anyway, I hope some of this may help you, I'd hate to think you were taking 1 mg Mirt for a week or more and matters/state of mind getting worse.

      Wishing you a little peace Si, you deserve it.  

       

    • Posted

      Hi Calmer,

      Youve hit the nail on the head with it all there except been of Mirt now day 9 and the anx was there before i started the Mirt .  I'm getting sweat nothing off my GPs and shrink so I asked my pharmacist what he think i should do.  Hes all for me staying off the Mirt now and believes it should be out of my system.  I've stopped having suicidal thoughts now i'm off all the drugs and that is a big relief.  I have had one negatove thought today and its my planned move to Las Vegas, I thought I can't do it I can't go.  This is how I felt about going on holiday and when I started having panic attacks after being on Sertraline for 4 days.  I'm having a hot flush now as I type!  I'm going to be OK and I'm going to do this.  I have to stay positive.  One thing I've not mentioned is in 1999 i was diagnosed with PTSD.  I went one valium back then and had sessions with shrinks for that and AA meetings.  I always say it was meeting my now wife that got me back in a good place and not the drugs or the little sessions with shrinks.  I don;t have PTSD now.

    • Posted

      Hi Si

      So were you on Sertraline for 4 days when panic attacks first started, it's impossible to say if the drug or a build up of anxiety caused those PA's. It sounds like you've made your mind up that AD's are not for you anyways.  

      I don't suppose the episode in 1999 is related to this one necessarily BUT believing so will undermine your confidence, as will letting this bout of Anx & Dep DEFINE you ... in fact most people say hitting rock bottom makes then so much stronger, and I know the CBT that you are reading around will help you to move on and be even stronger.  

      So glad your wife is supportive and you have no problems with the PTSD now, that's a blessing.  

      So it's now 9 days off the Mirt, and everything else for that matter smile  great, hope it continued to be good for you Si.

      There are folk who recommend Phenergen for sleep aid on this forum and other support sites also, just wondered if you might like to know, although I know you struggled breathlessness with one drug, very important to mention this to the pharmacist in future.

      Hope you have a good night, sleep tight  smile

       

    • Posted

      Major life change to ship out to Los Vegas, take your time, put off your decision for a week or two to see if it will take pressure off you for now, I know you said you needed to decide soon.  God knows we'd all be having a little melt down with such a big intention.
    • Posted

      Oh dear, si675, you've had quite a trial!  Being on valium for three days is actually enough to causae dependence, believe it or not!  And then swapping around trying different meds...they really threw your nervous system into disarray!  That is interesting that the first real anxiety was CAUSED by sert; anxiety is a side effect, paradoxically.  And then the fear of night panick just ramps up the anxiety more, and given it was chemically induced to begin with, throw in all that cortisol and the added headaches of travel, and you've got the Perfect Storm!  Then throw all that valium into the mix, plus more swapping around on drugs...how long were you on the Sert?  Was there a taper off or did they just switch you straight the other meds?  How many different drugs were there in between and how long on each? You mentioned six botlles.

      It is really individual, but mirt can in fact cause dependency in such a short time...i was only on it about 6 weeks before tapering.  My first cut was 20% and I experienced a numb tongue/lip sensation for quite some time.

      Yes, reinstating 1 mg might help a little, even though it sounds like mirt never really helped, probably because you were in withdrawal from Sert (may still be) and had all the other destabilization due to all the other med trials.  I think your best bet is to try that small dose, give it at least four days to see if you benefit, and then sit tight there.  

      When you say you are stuck at step 1 because you can't figure out what is causing the problem (of your anxiety?), I think that is because the problem is chemically induced, not related to your past.  The best you can do is self-care to support yourself with time being the only real cure.  We all hope that there is some other med we can take that will make the withdrawal and/or destabilization stop, but there is nothing, but time.  It helps to understand what is happening.  I still encourage you to join SA and put your story up there so that the mods can have a look-see and determine if there is any wisdom in taking 1 mg of mirt...or...how long ago did you come off the Sert?  I still think there might be some withdrawal from sert going on.

       

    • Posted

      D'oh, brain fart!  15 g!  I make mistakes like that all the time, cognitive problems due to these drugs and all!
    • Posted

      I can agree with your logic, Calmer!  Thanks for straightening that out.  I just wanted to know what the history with sert was because that may be in the mix as well.  I know when I went on mirt, I didn't realize I was in protracted withdrawal from Effexor, and the mirt couldn't hold up to that.  So then I reinstated Effexor, and that is when everything turned around. Now I am tapering off both!

      Mirt is often prescribed with SSRIs, the belief being that because they work on different receptors they have a synergistic effect together, better than each alone.  So, how long ago was Si on sert and at what dose did he come down from, and how quickly did he come off, or was it a cold turkey?

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