Depression not responding to antidepressants
Posted , 6 users are following.
Hi, I have been suffering with severe depression for 8 months (triggered by a health scare which is resolved). I was put on Sertraline but had such a bad reaction had to be taken off after a week. I then tried to cope without medication but couldn't.
I am currently on Mirtazapine (30 mg last 10 weeks) and Venłafaxine (5 weeks, last two at 225mg). I am not seeing any improvement at all, if anything, I'm getting worse. Yesterday, for the first time in a while, I felt actively suicidal. Mornings are absolutely terrible.
I'm now petrified that I have treatment resistent depression as I cannot continue to live like this. Please help, this time last year everything was fine but now I don't recognise myself or my life. I have had counselling and CBT.
I'd be so grateful for any advice x
2 likes, 8 replies
dinky_dee gen07717
Posted
I too suffer with depression & have had GAD now for several years. I'm not taking anything for it at the moment but tried Mirtazipine but had a bad reaction to it. I suffer with SAD & have a trapped nerve which is making everything worse for me. spenind most days in tears alone. I was diagnosed with "acute depression" 15 years ago & put on Sertraline, they kept upping the dose & I didn't feel like that was working for me either. Is it hard to find the right medication & can be very frustrating. that's good that you've had counselling & CBT, did you find that they helped you?
gen07717 dinky_dee
Posted
I'm under a psychiatrist and have a follow up appointment with him soon. Mirtazapine and venłafaxine are known for really helping people when other treatment hasn't and that's why I'm so scared that I'm not going to get better. I really try to think positively but it's getting more difficult each day.
CBT and counselling wasn't a great help.
The psychiatrist believes my type of depression is severe but the type that would respond well to medication. After increasing the dose of venłafaxine from 75 to 150mg I had 3 normal days, I couldn't believe it, I thought that we'd finally hit the nail on the head, but unfortunately it didn't last.
i don't understand why that would happen, the change was too significant to be placebo.
Just cannot believe that this is happening to me xxx
dinky_dee gen07717
Posted
mjmdesk gen07717
Posted
I know what you're going through. Back in the '90's I suffered from several suicide attempts. After on time I was put on too strong an anti-depressant (Luvox) and I became psychotic. I won't go into detail about it but will just say that I was soon put on an anti-psychotic medication named Olanzapine. Later turned out that I was alergic to anti-deprssants. They just made me more manic and delusional. I'm bi-polar. The anti-dedpressants made my life a living hell. My psychiatrist later put me on mood stabilizers instead, She put me on Carbamazepine and Divalproex. She reduced the dosage of the anti-depressant. Turns out that I can't take anti-depresants any more. Mood stabilizers seem to keep me relatively stable although I still suffer from a little too much mania. As it turns out I found that there is no magic formula for all people. Everyone reacts to medication differently. As is your case. You just have to stay in constant communication with your doctor and tell them how lowsy you feel and that you want to try a change in medication. Ask if they think mood stabilizers might work for you. From what I've heard, they really do the trick for a lot of people. They often have fewer side effects than just anti-depressants. My advice is to stay in constant communication with your doctor. Often it's trial and error trying to find the right medication or combination thereof. Sometimes it takes months getting a person the right meds. But it's worth it in the end once you've found the right one(s). Good luck Genn. I'll be thinking of you especially when I think back on what I went through to get the meds right. You can do it if you trust your doctor to be open to making changes. God bless. xxoo
marie31094 gen07717
Posted
Im sure if I can give you any advice then I would be more than happy to do so or if it makes you feel better to leave a message, then please do so. Remember - you ARE NOT alone!!
gen07717 marie31094
Posted
After a few weeks of taking the tramadol I felt mildly depressed and saw my doctor who put me on fluoxetine, telling me to stop the tramadol because of serotonin syndrome, after 3 days I was then put straight onto Sertraline as I didn't feel 'right' on fluoxetine and what followed next was the worst 7 days of my life. I was taken off everything but put on propranolol because the anxiety was so extreme and then what followed was this horrendous depression which is a million times worse than the mild depression I originally went to the doctors with.
I'll never know if tramadol caused the original low mood but I am certain that there was an interaction between tramadol, fluoxetine and Sertraline which cause that horrendous 7 days. I felt like I was being poisoned and was lying my mind. Terrible experience xxx
gen07717 marie31094
Posted
marie31094 gen07717
Posted
Take care. X