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I had a positive culture and negative blood test?

Posted , 3 users are following.

ladybug2910
ladybug2910

I am very confused by this. I have a culture done last year in june for hsv and it came back positive, recently got a full panel STD screening and it came back negative under HSV 1&2. I've been on valacyclovir for some time and acyclovir before that. But I was on and off in the beginning, but from what I have read, antivirals should have no effect on your IgG test. Has this happen to anyone?

1 like, 6 replies

6 Replies

  • john71455
    john71455 ladybug2910

    Posted

    Any test could go wrong. I had different results with different conditions and test method.

    Did ur doc confirm its herpes by visual diagnosis ?

    • ladybug2910
      ladybug2910 john71455

      Posted

      she said it most likely was HSV2 so she decided to do a culture, which was positive.
  • FelizCastus
    FelizCastus ladybug2910

    Posted

    It depends how much "off time" you had from the meds following your outbreak. What's the longest period you weren't on any meds?

    • ladybug2910
      ladybug2910 FelizCastus

      Posted

      MAYBE a month or two consistently off of it. On some forums people say antivirals can give you a false negative and some say it has to effect on your IgG test. So I am just trying to figure out how this could be.
    • john71455
      john71455 ladybug2910

      Posted

      Antiviral has effect on igg as it finds only antibody

      Only 100% test is PCR dna during outbreak or culture test as both finds actual virus but has to be during outbreak only.

    • FelizCastus
      FelizCastus ladybug2910

      Posted

      Your body takes around 3-4 months to develop full IgG antibodies naturally. The IgG test may detect it earlier. The antiviral meds, however, halt initial IgG antibody production, so if you have been on the meds consistently since your first outbreak with insufficient breaks to allow for adequate IgG antibody production, you may test negative despite being infected.
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