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I have just started methotrexate on rheumi's advice. Still on prednisolone forPMR and recent diagnosis of GCA and one year in. I have noticed an increase in arm and neck pain over 4 days since first mtx dose. Is this expected initially? No other side effects experienced. Glad to hear any thoughts.

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  • Posted

    That was one of my experiences with mtx. It can cause muscle and joint pain - as if we didn't have enough! - and for me it seemed to magnify the PMR (which was well managed on pred before) and make what are usually said to be pred adverse effects more noticeable! I'd never been hungry on pred - until I added mtx. And I gained about a kilo during the 4 weeks on mtx - and it hasn't gone yet.

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  • Posted

    HI, Ive been on methotrexate for 4 months along with 6mg of pred.

    Ive had a really stiff painful neck for about four weeks but put it down to me reducing the steroids.

    Ive also had a hacking cough for five weeks! The doctor wants me to have a chest xray to make sure all is ok!

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  • Posted


    I've been on pred for about 8 months now, started on mtx about 5 mths when specialist said it was'nt PMR but RA ??? now he has started me on Plaqenil. I figure he is the doctor BUT I'm on those three nasty drugs and most doc's think that is OK. I have now taken myself down to 2mg pred, and 20mg of MTX and informed him I was taking 1.5mg per day of CBD oil. I feel ok except for the excessive weight gain which causes me a lot of grief, I fell the other day ripped open my big toe and bruised my knee (I did'nt need that) I could'nt get up without help so I was stuck until my other half came home. So now we had muscle weakness as well.....just another of s**t to add to the endless days of trying to get my life back...

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