Mirtazapine paradoxical effect?
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I have been on Mirt since November starting on 30mg. I started to have nightmares, nausea, anxiety, diarrhoea after about 5 months. The doctor reduced it to 15mg and all was ok for a while but have started feeling awful again. I saw Dr this morning and he is going to ween me off it over 2 weeks. I also take Fluoxetine which I tolerate well. My question of anyone is: has anyone had this experience on Mirtazapine? Did reducing/coming off help? My Dr mumbled something about Mirt having a 'paradoxical effect'. ?
0 likes, 7 replies
elainec33 Jean1968
Posted
mud93433 Jean1968
Posted
Mirtazapine is more sedating at lower doses. At 7.5 or 15mg, it really knocks you out. 30mg is a bit less dedating, 45mg is much less. That's the "paradoxical effect."
It might be that the two ADs you are taking are too strong for you, causing your brain to build up too much seratonin, which can cause the symptoms you describe. It's called Serotonin Syndrome.
Can you talk to your doctor about that?
elainec33 mud93433
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Jean1968 elainec33
Posted
elainec33 Jean1968
Posted
I will. I took the 7.5mg last night but then I got stuck on the computer which is fatal as it was gone midnight and then I don't sleep very well anyway. I have a few other problems going on like the anxiety of severe osteoporosis, one of the reasons I would like to get off the mirtazapine as these type of anti depressants taken long term can cause osteoporosis. I also have suspected primary hyperparathryoidism and currently nursing a molar extraction that has left me with a lot of discomfort so I feel a bit like something the cat has dragged in this morning (I have four cats lol) so will be difficult to know whether it's the tapering of mirtazapine or just me generally feeling rubbish.
Jean1968 elainec33
Posted
Sorry to hear are not feeling great at the moment
I also started 7.5mg last night so fingers crossed.
elainec33 Jean1968
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