Posted , 5 users are following.
Hello,
I hope someone can help me out. I am on mirtazapine for 4 months now. First i was on 7.5mg for a month, then 15mg. Soon i could not tolerate this dose, and reduced to 13mg. Was fine at this dose for a month. Then on Early september, i started to feel severe agitation on this dose and was force de to reduce. Reduced to 7.5mg, on the third day of this dose i was severly sedated, was Iike i wanted to be awake and my brain wanted to shut me off. I dont understand why this happened , because when i was at this dose the first time for one month, i didnt even felt near as sedated as i was. Now upon reducing, after being on 13mg for almost two months, how can this happen? So i reduced to 3.75, was on 7.5mg for 3 days only, because i was almost like fainting the entire day. On 3.75, after 3 days my sleep suffered for one night, but after 5 days, i felt much sedated, but not as much like on 7.5m, i persisted on 3.75mg, after 7 days and now it seems to be more stable. Never the less, i feel extremly tired during the day, hang over like a train as passed over me. I tried even to updose to 4mg, but felt too much agitation restless legs, returned to 3.7 and it called down. So it seems i am stock on this dose. Any body got this inverse reaction? Normally i heard it would be the opposite of sedation when reducing. If so, did you notice the same reaction after a drop in dosage again? Is like my brain is inverted.
Thank you.
0 likes, 31 replies
caroline72090 mirtout
Posted
I'm also trying to come off mirtazapine. I'm down to 3.75mg at mo and having all sorts of withdrawal issues. I'm going to carry on until I've done 3 weeks on this dose and then halve it again. I'm determined to get off all medication as I have had no benefit in over 2 years - in fact the opposite and I have lost faith in doctors. It helps to know other people feel the same and that others have managed to get through this.
mirtout caroline72090
Posted
caroline72090 mirtout
Posted
I'm sleeping reasonably well luckily. Just chopping 15mg tablet into 4 at mo as it's not worth discussing alternatives with doc. My family are doing their best to help me through. I hope you have good support too.
ann55375 caroline72090
Posted
mirtazapine never really did much for me, i c ouldnt get the dose up above 22.5. Have been hovering around 7.5 for ages whilst trying others with no luck. Now down to 3.75 and i feel nauseous a lot, did also when higher dosage, and insomnia has kicked in. I am just so low doing things is a trial. I just want to know if this will start to feel better when i finish taking this med or am i going to have to take another anti dep instead. I have tried many and my body doesnt like them. Do you think i am just suffering withdrawals and thats why depressed. Are you on any other meds. I have diazepam, keeping it below 10mg so hope easier to get off.
caroline72090 ann55375
Posted
ann55375 caroline72090
Posted
Calmer mirtout
Posted
The lower doses of Mirt can be more sedating for sure. If I were you I would slow the taper down now, stay at 3.75mg for at least 2 weeks, or to be sure as you have upped & downed the doses for 4 weeks, let your CNS settle for a while. I think the sedation will be the same - don't expect that to improve really, not until below 1 mg.
The way forward is to taper no more than 10% every 3-4 weeks to avoid all the WD symptoms. It is possible to make a liquid from Mirt so that enables smaller doses.
If you can
caroline72090 Calmer
Posted
Calmer caroline72090
Posted
I put this up recently, it is on this forum. It takes a while to work it out, take your time & good luck.
https://patient.info/forums/discuss/mirtazapine-making-a-liquid-to-help-tapering-614122
mirtout Calmer
Posted
I now some people who had to do CT because of adverse reactions months after use of some med. I hope i am not one of those and that the CNS is only adapting to the amount of drug i need. I also found that mirt is still masking my zoloft protracted withdrawal. I notice that when the half life reaches at 19:00pm i notice some symptoms of zoloft more stronger, like the impending doom feeling and the sound sensitivity. What do you think about this?
Caroline: Yes, my parents are one of my lines of help. I could not do it alone. But i also have a strong belief in God who is helping going trought this with my prayers. I am glad your sleeping. It removes lots of burdens.
mirtout
Posted
Calmer mirtout
Posted
Trouble is with Mirt tapering, symptoms can come & go, windows & waves, some days here next day gone to return again. There is no way of knowing which symptoms are from which drug (Mirt/Zoloft) but I do know its best to use the same taper for Zoloft i.e. no more than 10% every 3-4 weeks/or 5% every 2 weeks for the sensitive (me too).
That "impending doom" feeling comes and goes quite quickly right? Its not a "day dream" but a "nightmare dream" that passes quickly maybe ... ? If you didn't taper the Zoloft slowly I can understand you might have symptoms ~ I haven't experienced that, but if its too hard you might want to take a small dose perhaps to ease up the symptoms.
The agitation, yes, Mirt', best to hold each dose for 2 weeks, you're going way too fast, I would stay at your current dose for a minimum of 2 weeks. You might find those symptoms ease up, just wait, until the symptoms subside maybe?
Best wishes.
caroline72090 Calmer
Posted
caroline72090 mirtout
Posted
I'm glad you have plenty of support. I've just dropped to 1.8mg so let's see what happens next. Bring it on Mr Mirtazapine!
ann55375 caroline72090
Posted
caroline72090 ann55375
Posted
Hi. Sleep seems ok although I'm not sleeping as long as I used to. Headaches and anxiety symptoms are there but I'm coping so far. I'm hoping to stick with this dose for 3 weeks and then stop altogether. Hope it goes well for you.
mirtout Calmer
Posted
Hi Calmer,
Air hunger seems to be vanished. Still at 3mg.
The impending doom feeling is there most of times. I already tried zoloft reinstatement and it made my insomnia much more worst, had to drop. Tried pregabalin wich helped to attenuate symptoms, but had a bad reaction to it and had to drop it. When you did your taper of mirt, didnt you had high pressure rebound for the strong blocking of alpha2 receptors? I already had low pressure when started mirt, and it lowered even more, but one month and my body adapted, só i guess if i taper, i will get a high pressure rebound.
Other problem is that the pills produced here in my country have always 5% more or 5% less of error range, but i think its the same process in every country, i think? Did you knew that? When tapering or taking you are always in error. I could be taking 3.2 or 3 or 2.8 without knowing it.
mirtout Calmer
Posted
ann55375 caroline72090
Posted
mirtout caroline72090
Posted
Hi Caroline,
Insnt the drop from 3.75 to 1.8 a too much BIG jump? Its 50% the dose. I am now battling at 2.8mg from 3mg, and i only made this drop because i was forced, started to feel agitation. Feeling also a pain on my lower left abdómen. My problem is mirt is masking my already severe insomnia from zoloft. I hope my brain doesnt reject 2.8mg
ann55375 mirtout
Posted
caroline72090 mirtout
Posted
caroline72090 ann55375
Posted
Hi Ann. I'm still on 1.8 and finding it tough. I have stayed with family to help me through but came home yesterday. It's difficult on my own because I just cry and become overwhelmed by anxiety and sadness. I am worried that this is in fact how I will feel even when I am off the tablets. How are you doing?
ann55375 caroline72090
Posted
i domt think raising it will help as it is sending all sorts of confusing messages to the nervous system. Dropping it lower will cause worse problems just now too.
i am scared to go back to dr as when i explain symptoms all they can do is either increase it, or give a new ome, neither of which has been helpful in the past.
this is sheer hell and imhave read about it but just want to be free of this drug, like you. Domyou find that even trying to do,the simplest of things like going for a walk or to a shop is hard, i just cannot see friends as im in such a mess.
anyone out there for help.
caroline72090 ann55375
Posted
Yes I recognise everything you say. I'm not sure if the diazepam is good in the long term but you must decide on that. Don't try to give up both though. I was on lorazepam for a while and didn't realise how addictive it was. I'm off it now but it was very hard to get off it. You certainly have to taper those meds very slowly. Get more advice. I've got 5 more days on the mirtazapine and then I'm going to stop. It will probably hurt a lot but I am determined to do it. It's hard to keep positive. I will be thinking of you. We are travelling the road together.
ann55375 caroline72090
Posted
caroline72090 ann55375
Posted
I can't advise you on what you should do. I think you have to talk to someone you trust and decide on your plan and make sure you have people to lean on while you go through it. Read up about Diazapam and perhaps chat to unbiased people about that medication. Try natural things to help. Mindfulness, exercise, vitamins etc. Take care.
Join this discussion or start a new one?
New discussion Reply