mirtazapine withdrawal and sertraline side effects

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  I have been on mirtazapine 25 mg for the past 1 n half year. Then my doc suggested I come down to 15mg and added sertraline 100mg. Long story short i have put on like crazy , i am not able to control my food craving nor able to exercise. Mirta helped me a lot in my depression but my weight gain is causing me more depression. So my doc got doent o 7.5 mg and since last week she asked me to go off mirta and increased sertra to 200 mg. I could see a huge difference in my appetite and im very happy about it. But the side effects are horrible. Diarrhea is worse, i feel tired, soemtimes i feel like im high , don't feel like eating , difficulty sleeping and then morning not able to wake up. Now i want to know is this a combination of both changes or is it only coz of one med. Also i am ready to go through these side effects as long as i will loose weight. Will i loose weight and how long will these symptoms last? I am holding on strong. sad

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  • Posted

    Dear Vanp,

    I was put on Mirtz for sleep and anxiety, which eventually it did help. I am also on fluoxetine. However, like you I could not stop eating sweet stuff. I put weight on. I came off very mirtz slowly. I am now back to normal eating. It's known to put weight on. May be you shld taper off them, but do spk with yr GP.

    Good luck.


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  • Posted

    Mirtazapine is difficult to discontinue and it is advised to do it slowly, no more than 10% every 3-4 weeks.  Any sickness, tummy flu, anxiety and insomnia are normal discontinuation/withdrawal symptoms of Mirt.  Your doctor should know to taper slowly and I am always upset to read of the bad advise they give to us patients ggrrrrr.....

    Ive written up advice links under my status for a full informed choice youu can read them by clicking on my name & following the links.  

    As for Sert' start up symptoms, I wonder if you go to the Sert pages on the forum and ask there it might be simpler for you.

    Wishing youu well.

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    • Posted

      It's different for everyone, but for the majority it can last a long time, months & months ... not good news, am sorry.

      Treat any sumptoms as they arise or ask on here for reassurance. Glad to read you are feeling strong. 😊

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