Mirtazapine Withdrawal - Anxiety

Posted , 6 users are following.

Hi, I need some help. 

I was on Mirtazapine for about 6 months on 45mg. I felt like it wasn't helping as much as it used to so I asked to swap to something else. My doctor had me change to Cymbalta and he told me to just swap, no tapering. I stopped taking Mirtazapine and waited a few days before talking Cymbalta for a week and a half.

Cymbalta turned out to be terrible, I couldn't stay on it. But now I'm having withdrawals from them both. I have so much anxiety its ruining my life. I can't sleep, I can't sleep, I feel so nauseous that I cannot function. I am so anxious despite nothing bad happening. I am sat here doing nothing but my hands are shaking, my knees are shaking, it feels like my chest is being pushed down and my throat is tight and my stomach is tense and all I can think about is anxiety. It's been like this for a week and a half. I've lashed out at everyone in my life because this is killing me. 

I don't know what to do. I can't function. I can't get a doctor appointment before the 7th. I just want to go back on the Mirtazapine so this anxiety stops but I don't know if I should or not. 

I don't know what to do. Has anyone else gone cold turkey from 45mg Mirtazapine, and how do I deal with these withdrawals? Can I just take Mirtazapine again?

Sorry for the long, rambly post. 

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5 Replies

  • Posted

    Hi Baku... sorry to hear you're going through the same thing I did, but in my case I took mirtazapine for 3 years and recently stopped cold turkey, bad idea...I suggest going back on it so you can do a slow tapper, once you're feeling better you can slowly with help of doctor come off it, and just know all those crazy symptoms are normal and will go away, I'm on my 3rd month after stopping mirtazapine 30mg it was hell but I feel so much better, just stay positive, in order to succeed quitting this pill you have to stay positive and tell yourself that those symptoms will go away, stay strong!

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  • Posted

    I'm probably in the minority here but i think since you have already gone 1-2 weeks without it you should try to just tough it out. If you really need to maybe ask your doctor for a sleeping pill. Maybe doing some vigorous exercise or hitting up a sauna would help too.

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  • Posted

    Hi:   soooooo sorry to know of  all the anxiety you are experiencing.  I know it's hell.  Your physician should have NEVER had you switch cold turkey (even tho Mirt & Cymbalta re both SNRIs).  That's exactly what mine wanted me to do and I refused.  I've been taking Mirt for over 20 years.  Slow and I mean very slow tapering is the only way to go.  I agree with candy, go back onto Mirt (hope you still have some) but start low at 15 mgs.  If you put 45 mgs back in (the highest recommended dosage for that med.), you gonna cause your body a lot more upset.  If you don't have any left, call your doc. (don't wait for an appointment) and tell him you absolutely CANNOT function and that you want back onto Mirt (if you get script for 45 mgs. cut the tabs into 3rd pieces).  Good luck and never fret about rambling on here -- that's why this forum exists.   


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  • Posted

    Sorry to read of your suffering Baku, it is so distressing knowing that doctors simply don't know about the withdrawal effects of Mirt.  You say you don't know what to do, 2 options, stay as you are and see if you can handle the sickness (you can get nausea meds from your GP) the insomnia (try Phenergen - over the counter here in the UK, not US) or Benadryl drowsy, or more addictive med sleeping tablet, along with the anx' . OR  reinstate the Mirt ... the sooner the better as uptake/stabilisation will be more successful the sooner you do it - although it may take a few days.  It is debateable as to which dose you go back to, but if your long term plan is to try to gradually taper, then you would be better going to a smaller dose, I would guess if you only have 45 mg tablets to go to 33.75 mg, which is half a tablet + 1/4 of a tablet.  Buy a pill cutter from say Boots, OR if you can hang on and get 15 mg tablet take 2 plus a half tablet which = 37.5 mg.  That's what I'd do anyway, hope this helps a little.

    I did a very slow taper off Mirt, it took patience but it is doable, slowly. 

    Wishing you well.  smile  


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  • Posted

    Hi Baku, Mirt is a difficult drug and the big plus it lets you sleep. I quit mirt recently  (too quickly ) and am on Citralopram now .... 4 weeks and still waiting for it to kick in...if it ever will. Zopiclon..sleeping tablet and cocodomol have got me sleeping for 5-6 hours and irregular diazapan gets me through the bad bits. My heart goes out to you for the pain you are experiencing.
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