Mirtazapine Withdrawal from 45mg

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Hello all,

I am writing this post to provide the assurance I was seeking when starting my journey of mirtazapine withdrawal.  I'll first start with some background.  Since high school I had always had trouble sleeping.  This past year, as a senior in college, I finally saw a doctor regarding my insomnia.  I was started on 15mg mirtazapine, which seemed to have no effect.  My dosage was soon increased to 30mg to see if my insomnia would improve.  A few weeks after starting 30mg I started developing terrible anxiety/panic.  My doctor, thinking that there was no way the mirtazapine could be the cause, again increased my dose to 45mg.  Soon after starting this dosage i felt absolutely awful, experiencing constant anxiety, depersonalization, terrible depression etc. I had no idea what was happening to me.  

A few weeks later, after having been on the drug for about 4 months, I had a thought that maybe it was actually the meds causing my struggles.  After pleading my case with my psychiatrist, she finally agreed that I could possibly be right.  Assuming I would need to taper, I asked my doctor what type of taper schedule I should use, and she informed me that mirtazapine actually didnt require a schedule, and that I should just reduce by 15mg every week until I was off.  I took her advice, however lowered from 15 to 7.5mg instead of coming off.  All I can say is wow.  I did not even know the despair i experienced existed until I started my taper.  Once Lowering down to 7.5 I felt unbelievable depression, feeling like their was a ton of bricks on my chest at all times. I also felt a long list of other symptoms, such as unbearable anxiety, depersonalization,  severe tension in my legs, weakness in my left arm,  shaking and night sweats.

These symptoms still linger today 3 months later, however have greatly reduced to a mostly tolerable level.  I've found that my recovery has come in waves, as I'll feel great for a week then feel terrible for a few days.  All I can say to those trying to come off this drug is that you need to be ready to commit.  There is no shame in reinstating if you feel the need, as it took me several attempts to get below 7.5mg before I was actually successful, but you need to know that once you get through the intial withdrawal symptoms will improve. I hope this post can help give someone the peace of mind I was seeking, and good luck to all attempting to taper.

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9 Replies

  • Posted

    Hello mike. That's a superb post 👍. Well done for having the drive to taper and get through it !

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  • Posted

    Great post Mike, well done with sticking out the Mirt' taper.  Interesting to read that what is supposed to cure you makes you worse; I think when tapering 7.5 mg is a bad place to be for most from what I have read (me also).

    Did you manage to sort out the insomnia now without meds?  I read a book called "Say Goodnight to Insomnia" brilliant!

    Wishing you well Mike.

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    • Posted

      The ironic thing is insomnia is the only issue I dont have now. Since starting the taper i began practicing mindfullness meditation daily and it has changed my life, especially helping with sleep.  I highly recommend it regardless of someones life situation
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    • Posted

      Yes if only folk knew about it before the journey of Mirt or any other AD's, Benzo's, anti Psychotics etc ... 

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  • Posted

    Mike,

    Thanks for the info I'm just down to 15 mg from a high of 45 and it has really been a struggle with feeling dizzy, flu like, stomach issues and decreasing sleep to about 5 hours a night. I want to keep fighting it to get off but it is really hard. Hopefully I'll get where you are sometime in the near future, thanks again for sharing your story.

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  • Posted

    I've been using the mindfulness meditation also and it has helped me stay calmer but the insomnia is still an issue I struggle with unfortunately but been trying to use some of my mindfulness when sleeping to help me not get so frustrated about it.

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  • Posted

    Thank you for the feedback,I'm currently at week 5/6 off the Mirt and started to worry that there was something seriously wrong with me.

    I didn't think the withdrawals could be so powerful never mind lasting this long,

    I've never had Insomnia,Anxiety before and it's awful,I was prescribed Mirt to help meanly with sleep,

    I can't even have alcoholic drinks as my head throbs,I really hope I get my life back.

    Knowing that you went through this for longer then 6 weeks is reassuring,maybe there is hope.

    Thanks again,your comment has been really helpful.

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