mirtazipan withdrawal help needed
Posted , 6 users are following.
I am trying desperately to come off mirtazipan and I am trying to work out the best plan to withdraw, 26 days ago I reduced my dose from 30 to 15, although I am bearing it, the side effects are awful, I have a thick headache, nausea, trembling, but to name a few, today I burst into tears for no apparent reason, please can someone tell me if this is normal? I was hoping to cut the dose down by half again, does anyone know if this happens after each reduction ? And when is right time to reduce. Thank you in advance for your help.Margaret x
0 likes, 39 replies
norma72045 margaret77657
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margaret77657 norma72045
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norma72045 margaret77657
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margaret77657 norma72045
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norma72045 margaret77657
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elizabeth59941 norma72045
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norma72045 elizabeth59941
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margaret77657 norma72045
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elizabeth59941 norma72045
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norma72045 elizabeth59941
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jacqueline59667 margaret77657
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clarkio jacqueline59667
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The problem is Mirtazapine has a short half life 20-30 hours depending on the persons metabolism. By alternating doses in this way you are causing quite big fluctuations in the level of the drug in your system from day to day.
If you look at the charity MIND's website you'll find they have some really useful web pages on advice for withdrawing from ADs. They also don't recommend withdrawing by alternating doses by rather just by simple gradulal reductions.
As I say everyone is different and not trying to be little anyone's advise but, from personal experience, my partner was wrongly advised to withdraw from Citalopram (another drug with a short half life) by alternating 20mg doses rather than stepping down to 10mg and she still suffers effects several years laters.
My advice would be to just step down the daily dose as gradually as you feel the need. Split pills if you have to, or there is a liquid form of Mirtazapine available if that proves too problematic.
Good luck and take care of yourself
jacqueline59667 clarkio
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norma72045 clarkio
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margaret77657 clarkio
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clarkio margaret77657
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It's one of the reasons why when you start a drug it can be a while until you get any benefit as it takes a while for the accumulated level of the drug to build up. Its also why when withdrawing if you are going to get any side effects when dropping the dose they often appear a little while after dropping the dose (as you still have the accumulated level of the higher dose still in your system gradually working down it's half lives).
However everyone is different and what works for one person for withdrawing may not work for another. Sompe people tend to have withdrawak symtpoms more that others etc.
One of the problems with withdrawing is that it is sometimes difficult to tell what are withdrawal symptoms and what are whatever illness you were taking tyhe drug for re-surfacing. Again I would recommend having a read of the MIND web pages on Anti Depressant withdrawal as they cover this.
On the plus side you've done really well to get down from 30mg to 15mg. If you can bear it I would just stick at 15mg for a while longer and see if your symptoms get any better before attempting any more drops in dosage. Trust your body and take it as slow as you need.
norma72045 clarkio
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margaret77657 clarkio
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norma72045 margaret77657
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clarkio margaret77657
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Or it could be that Mirtazapine just makes your anxiety or depression worse. That's what I felt and is why I'm currently tapering off (down from 45mg to 12.5mg at the moment). However even if that is the case I would not just stop taking the mirtazapine. It's tempting to rush it and some people are able to go cold turkey but it's not recommended advice. Follow norma72045's advice below instead and take your time, frustraing as that can be.
I'll post the link to the MIND web pages in a seperate post but it probably won't appear for a little while as posts with external links need to be moderated to appear.
clarkio margaret77657
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http://www.mind.org.uk/information-support/drugs-and-treatments/medication-stopping-or-coming-off
margaret77657 clarkio
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clarkio margaret77657
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In the event I hav found it remarkably trouble free and certainly feel better than when I was on the higher doses. Have tapered down from 45mg to 7.5mg currently. For me I cut down by 7.5mg every 7-9 days and have been going a bit slower dropping down from 15mg. I have just usd 15 and 30mg tablets and cut in half etc. as needed.
As I say I haven't had any real troubles doing this, certainly none of the symptoms you list. But everyone is different and reacts differently. It may be that you cut down by a bit too much too quick and you may have to taperdown a bit slower than you would like. I've been on the Mirt since January this year, whereas you said you've been on it for 17 months, so maybe not that much of a suprise that cutting your dosage by 50% has caused some problems. Not trying to be-little your suffering in any way just that for most people we need to realistic about how quickly we can taper down off a drug our body has got used to over a long period of time.
Of you've not seen them it might be worth seeing your GP if nothing else they could maybe help manage some of the symptoms you're getting.
clarkio margaret77657
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margaret77657 clarkio
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norma72045 margaret77657
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clarkio margaret77657
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I think sometimes GPs are a bit unwilling to recommend cutting pills in half which given Mirt only comes in 45, 30 and 15mg varieties might be why they suggested going from 30 to 15.
Regardless, rather than looking back and wishing thinsg were different the important thing is to focus on how you feel now and going forward. I think I agree with norma above (and your MH doc) that getting off the Mirt would be best for you. Once off you can always evaluate how you feel and what you wish to do next.
Do you think your withdrawal symptoms have waned at all since your original post?
margaret77657 clarkio
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margaret77657 norma72045
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clarkio margaret77657
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However as you say yhou don't want to jump straight into taking another drug which I can understand. You've been on the reduced dose for about a month now right? I have read other posters saying it's taken them a while to ride out withdrawal side effcts so you might want to hang in there a bit longer and see if things get better. If they are genuine withdrawal symptoms they should start to ease eventually.
The other option would be to slghtly increase the dosage of Mirtazapine (say to 22.5mg) and see if that eases your symptoms and if it does once stablised try cutting down again more gradually. I can appreciate you may not want to try this though as you've spent a month grinning and bearing it so far.
Did you read the MIND pages? When you get to the one listing withdrawal side effects Mirtazapine is a drug with strong anticholinergic effects so you could expect to be feeling some of the side effects listed under that section which include feeling sick, insomnia, flu-like symptoms etc.
Sometimes it helps to know why it is you're feeling the way you do even if there is still no easy answer.
norma72045 clarkio
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margaret77657 clarkio
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norma72045 margaret77657
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clarkio margaret77657
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Had you got to the point on the 15mg where you felt ok then? If not then as norma says to drop again seems like rushing it a bit.
Even if you did feel ok on the 15mg, given the problems you had going down to 15mg I think a drop down to 7.5 mg is maybe pushing it a bit in your case.
It's just my opinion but I would probably say try taking 11.25 (i.e. 3/4 of a 15mg pill for a while and see how you are on that. Either that or get a 15mg pill and just cut a bit of a corner off and see how you are. If you feel ok after a week then cut a bit more off etc.
HTH
margaret77657 norma72045
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margaret77657 norma72045
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clarkio margaret77657
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You stated in an earlier post that your Mental Health Doctor (Psychiatrist?) advised reducing and stopping the Mirtazapine and starting Sertraline instead. Given that I would go back to your GP or another GP at your practice, they cannot recommend you increase the Mirtazapine dose if the specialist doctor has said to reduce it with an aim to stopping it.
I would explain to them what a hard time you are having coming off the Mirtazapine and that you do not wish to rush into taking another AD until you can "baseline" how you feel without any drug in your system. If nothing else they should be able to presribe you the liquid form of Mirtazapine which would allow youto reduce more gradually when you feel able.
Again my sympathies at not having an understanding GP, whilst not able to offer any magic cure my GP is very good about encouraging patients to decide theit own couse of action, so it may be you have to switch to another GP if necessary.
Sorry this is probably not much help. The only other piece of advice I can give is try not to fight how you're feeling, just accept it for now, say to yourself "I'm not feeling great at the moment but it will not last forever so for now I am just going to live with it". I know it sounds a bit like hokum but often acceptance is enough to lessen how we feel.
margaret77657 clarkio
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