Negative Blood, Urine, & DRE tests, but elevated PSA

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57 year old with minor urinary pain starting my stream.  No pain otherwise

PSA went from 2.25 to 3.44 in 15 months.   

Doctor said the velocity warranted more  testing.  

CBC blood panel, urine w/microscope, and 2 DRE's were all normal although one Doc felt my prostate was mildly enlarged.

I guess my question is whether the good blood and urine results rules out infections, and points more towards the velocity having an ominous meaning to it? 

The two PSA scores were done at different labs, and the higher score I was off my statins, riding a stationary bike regularly, and a bit dehydrated.  But would that be enough to explain the quick jump? 


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8 Replies

  • Posted

    Yes, avoid bikes, sex,DRE's and any prostate medications for about four days before PSA testing. When my prostate was rather big 135 grams my PSA was around 9. After laser surgery it went down to 0.74

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  • Posted

    Hello J5  Don't be rushed into anything by any doctor.  With everything coming out normal.  PSA could be high because of many things.  Riding the bike, sex, the dehydrated.  I'm going through something like what your going through.  My PSA went from 0.7 last year to 2.2 this year.  I will have a another PSA done in 3 month's but my urologist said it could be a infection or prostatitis.  I'm just taking day by day and I'm not going to worry about it.  Try to relax   Ken 

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  • Posted

    PSA can vary depending on many your PSA change is not alarming.... Take a 2nd opinion...
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  • Posted

    Many things can raise PSA along with those already mentioned including not enough sex, and too much sex.

    Don't let the DR. do a rectal biopsy. There's no better way to get a severe prostatitis then jabbing a large needle many times through a non sterile colon, and they all are, into your prostate. Also oral antibiotics will be of little help to prevent the infection. Many have had prostate infections for years. If antibiotics could deal with them, that would not be the case. Also, absent an MRI telling the DR where problems might be, he/she is literally playing pin the tail on the donkey with a blindfold in place. The doc may completely miss a problem, or worse, find a slow growing cancer and recommend watchful waiting while missing a dangerous aggressive cancer right next to it.

    If further psa testing indicates a biopsy, insist on an MRI guided peritoneal biopsy. If your doc won't or can't do it, get another doc who will.


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  • Posted

    Very excited!  I received the results from my 4Kscore results: The 4Kscore Test relies on the measurement of four prostate-specific kallikreins in the blood: Total PSA, Free PSA, Intact PSA, and Human Kallikrein 2 (hK2). The blood test results are combined in an algorithm with patient age, digital rectal exam (nodules, no nodules), and prior negative biopsy (yes, no) to give physicians a personal score for each patient. The 4Kscore Test predicts the risk percent score from <1% to >95% of a man having aggressive cancer in a prospective biopsy.

    My doctor said my PSA went down from 3.44 to 2.88 and that the odds of me having any cancer in the next 10 years is only 6%.  This experience was scary, and I hope the best for all of you going through this.  I will do my best to make sure my friends and family understand the mixed messages an elevated PSA score can bring, but there are tools to rule out the worst case scenario. 

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