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Not tolerating PPI's - what do I do?

Posted , 8 users are following.

dani2590
dani2590

I'm 25 and was diagnosed with grade a oesophagitis about a month ago. Dr gave me Rabeprazole and within 3 days I developed what appeared to be some sort of allergic reaction to it - I had a severe swollen an inflamed throat. Severe dry mouth and nasal passage. I ended up in the ER as I became dehydrated from being unable to drink or eat properly. I didn't think it was the medication I thought maybe I had a viral infection. I came off the Rabeprazole and literally within 2 days throat was starting to feel better. Meds were replaced with 40mg Nexium. It's been 5 or 6 days and again my throat is beginning to swell and become very sore. I'm afraid I have some sort of allergy to ppi.

I would appreciate any advice. What should I do? Lower my dose? I think I need to go back to my specialist asap.

2 likes, 22 replies

22 Replies

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  • rex_44766
    rex_44766 dani2590

    Posted

    Dani there are some things we amateur sleuths shouldnt mess with and drug allergies would be top of the list. Hop on off to your specialist. You will find his office will give you an email, pager number or 24 hour emergency number. You will find that this will reduce your stress at least 50%. Its sort of like having your own life gaurd there by your side. When going to any new specialist I always ask for this info.
  • dinand06158
    dinand06158 dani2590

    Posted

    I have ear problems since i was a child, so i can't say it is because if the meds.

    What i do know is that after a couple of years using Losec, i was diagnosed

    with a Cholesteatoma lol. Oesaphagitis is not something small. Only PPI's Would do the trick untill it is healed. We should always try to find the cause though.

    Getting used to another diet and testing for any allergies would be good too.

  • shugirl14164
    shugirl14164 dani2590

    Posted

    I am experiencing the same symptoms. I had pharyngitis from omeprazole. The other ppi's that i took makes my throat swell and had difficulty swallowing and breathing. I just tried famotadine, h2bloc and i had the same reaction although lower in intensity. How are you dani? How did you manage it? Thanks
    • Barretts
      Barretts shugirl14164

      Posted

      Strange reactions. All the symptoms you describe are typically those of reflux. The medicines reduce acid but shouldn't exacerbate reflux; they make the reflux less dangerous.

      Check out the section on reflux in the Down With Acid book.

    • shugirl14164
      shugirl14164 Barretts

      Posted

      I can feel it working actually but my body is having adverse reaction to it. My GI said it's because of my allergies. When I took citirizine after a really bad inflamed throat, i felt better. I keep on switching ppi's and its the same. I'm wondering if it's possible to take an anti-allergy meds after taking ppi or h2b.
  • laila7855
    laila7855 dani2590

    Posted

    Hey dani, I'm not sure if you still look at your messages but I have the exact symptoms that you have... I have really bad reflux and I can't even take medicine because of the swollen throat part and difficulty swallowing that it causes from the medication .. I'm not sure what to do or what's causing it.. Hope you're feeling better and if so would you please let me know if you found out the caused of your issue..

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