Took a higher dose and it had the opposite affect. Why???? Someone please help explain
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What's up you guys. I just started Mirtazpine about 1 week ago. I suffer from servere insomnia, racing thoughts,and depression. I suffer from PTSD. Apparently I've been suffering from it since I was around 4years old after attending my Grandmother's funeral. I have a obessive fear of death which doesnt allow me to sleep.I was put on 15mg. It definitely helped me go to sleep. It was like a miracle I mean I couldn't even fall asleep after taking 10mg of Xanax so I was very pleased with Mirtazapine.Last night after having a bad night. I was pretty upset so I decided to take 22.5mg of Mirtazapine and I had the most restless night. I couldn't sleep at all. Why did this happen? Can someone please explain. Am I building a tolerance already after a week?
1 like, 16 replies
susan32309 brian_55646
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brian_55646 susan32309
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taz91323 brian_55646
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brian_55646 taz91323
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betsy0603 brian_55646
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At higher dosages, the serotonin receptors begin to get blocked, and that is more activating.
Now, there's no proof to support the imbalance theory of depression, that it is correcting low serotonin. For years, this has been known, yet the myth persists. Studies proved that in a group of non-depressed control subjects, their distribution follows a bell-shaped curve, with some having low S, some high, and most in the middle. When depressed subjects were looked at, guess what? The same distribution was found!
So, let's say you are a high S depressed person and you take Mirt. Now you got WAY more S since the receptors are blocked, keeping lots more in the gap between nerves - now you've got a very activated scenario!
If you want it to help you sleep, keep it from 7.5 to 15 mg, for you, probably 7.5 mg. In your case, low serotonin wouldn't likely be the problem anyway, so no point pushing your S higher. I would be careful with SSRIs for this reason.
Now, if you were to stay on the higher level of mirt, this side effect might go away. Why? Because your nervous system would make oppositional modifications, down-regulating the serotonin system, to try to bring back your homeostasis. Now, if you want to come off, you have a problem, because as you drop the med, those changes will be left unopposed, and that causes withdrawal symptoms! It takes longer for the nervous system to return to it's default than anyone expects. So, do you want to continue and get your serotonin system hooked to the drug?
At the lower doses, where serotonin isn't engaged, your histamine receptors will similarly be affected over time, and Mirt has a way of getting its hooks into people quickly. So, be aware, that if you wanted to come off, you'd still have to taper slowly or run the risk of serious rebound insomnia.
I hope this makes sense.
Which came first, the insomnia or the depression?
brian_55646 betsy0603
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betsy0603 brian_55646
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Ok, what came first, PTSD or insomnia :-)
brian_55646 betsy0603
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betsy0603 brian_55646
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Melotonin is good for helping people fall asleep but not stay asleep. Some people find lemon balm helpful.
I'm just trying to get at whether the insomnia is driven by anxiety. Waking with a start is usually a cortisol surge, a hypersensitivity of one's alerting system. Cortisol normally rises in the early morning with light, but when hypersensitized, any ambient light could cause a surge. So, good sleep hygiene is improtant. Black-out curtains, sleep mask, covering lights from routers and such, clocks, not reading from tablets before bedtime, shutting off tv and computer by 10 PM, etc.
elainec33 betsy0603
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brian_55646 betsy0603
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betsy0603 brian_55646
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elainec33 brian_55646
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brian_55646 elainec33
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emmadale brian_55646
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When u get the medication we are on, it's the big boy stuff so we know their will be side effects....good and bad!
When ur doc decides to up ur Meds, if like mine they often double the dose so ur fine on what u have taken...and please don't think I agree with self dosing but I fully understand where ur coming from.
Probably it just gave ur body a big hit and may be why it sent u hyper...speak to ur doc to get his/her opinion. There are higher doses u can take and also things you can take with it to help it work better.
I am on 45mg and getting confused with other Meds missed taking mine for nearly 3 weeks...there were some difficult side effects but honestly even going total cold turkey...there are others I've found more difficult
Doubt this helps babe but hang in there x
brian_55646 emmadale
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