Dysmenorrhoea

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See also: Periods and Some Period Problems written for patients

Dysmenorrhoea is a term used to describe low anterior pelvic pain which occurs in association with periods.

It is thought to be due to an excess or imbalance of prostaglandins and leukotrienes in the menstrual fluid, which in turn produces vasoconstriction in the uterine vessels, causing the uterine contractions which produce the pain. The prostaglandin release may also be responsible for the symptoms of diarrhoea, nausea, headache and light-headedness which may occur in association with dysmenorrhoea.

Dysmenorrhoea may be thought of as either primary or secondary.

Primary dysmenorrhoea

Primary dysmenorrhoea occurs in young females with no pelvic pathology.

  • It often begins with the onset of ovulatory cycles six months to one year after the menarche.[2]
  • The pain begins with the onset of the period and may last for 24-72 hours.

Secondary dysmenorrhoea

Secondary dysmenorrhoea occurs in association with some form of pelvic pathology:

  • It is more likely to occur years after onset of menstruation.
  • The pain can precede the start of the period by several days and may last throughout the period.
  • There may be associated dyspareunia.
  • Secondary dysmenorrhoea may occur as a result of:
  • Dysmenorrhoea is very common although the precise incidence is not known, as it frequently goes unreported.
  • Primary dysmenorrhoea is the most commonly given reason for absence from school amongst adolescent girls and approximately 15% will complain of severe dysmenorrhoea.
  • Longer duration of menses, early menarche, smoking. alcohol and obesity are all risk factors associated with dysmenorrhoea.[2]
  • Females who are depressed and/or have poor social support networks are also more likely to experience pain.[4]
  • Childbirth reduces dysmenorrhoea and its severity diminishes with age.[3]

A presumptive diagnosis of primary dysmenorrhoea may be made on history ± abdominal examination alone in young patients who are not sexually active, and vaginal examination is not normally required in this group of patients.

Investigation of dysmenorrhoea is primarily aimed at ruling out underlying pathology and may include any or all of the following as appropriate to the individual.

History

  • Age at menarche.
  • Cycle length.
  • Whether the cycle is regular.
  • Duration of bleeding.
  • Timing of pain in relation to period.
  • Location of pain. Dysmenorrhoea is typically suprapubic but may be felt in the back of the legs or lower back
  • Smoking history.
  • Whether the patient is sexually active.
  • Obstetric history.
  • Contraceptive history.
  • Any features suggestive of underlying pathology (eg, vaginal discharge, intermenstrual or postcoital bleeding, dyspareunia).
  • Dyschezia and/or rectal pain or bleeding - particularly suggestive of endometriosis.

Examination

Abdominal/vaginal examinations are indicated if sexually active:

  • Adenomyosis - the uterus may be enlarged and tender with a typical 'boggy' feel.
  • Endometriosis - generalised tenderness in the pelvic area. The uterus may be fixed ± retroverted due to adhesions, and nodules may be palpable in the uterosacral ligaments.
  • Partially imperforate hymen (rare).
  • Vaginal septum (rare).

Additional investigations

  • Speculum examination to visualise the cervix.
  • High vaginal swab, chlamydial swabs.
  • Cervical smear, if due.
  • Pelvic ultrasound - if uterine enlargement or adnexal mass is present.
  • Transvaginal ultrasound.

Specialist investigations

  • MRI scan.
  • Laparoscopy.
  • Laparotomy with biopsy.

General measures

Patients may be concerned about the possibility of underlying pathology and, when appropriate, reassurance and an explanation of the mechanism of menstrual pain may be helpful.

  • Lifestyle changes - longitudinal studies have looked at risk factors for dysmenorrhoea and have found a clear association between smoking and dysmenorrhoea; patients should therefore be informed of this relationship and assisted in any attempts to stop smoking.[5]
  • Self-help techniques
    • There is some evidence for benefit from use of transcutaneous electrical nerve stimulation (TENS) (high-frequency) and locally applied heat.[6]
    • Anecdotally, many women find the following measures to be helpful in relieving the symptoms of dysmenorrhoea:
      • Tea - regular, camomile or mint.
      • Abdominal and/or back massage.
      • Lying in the supine position.
  • Complementary and alternative medicines - several dietary supplements and herbal remedies have been suggested but there is insufficient evidence to recommend any of them.[7] They include calcium and magnesium, thiamine, ginger, fish oil supplements, toki-shakuyaku-san (TSS - a Japanese herbal remedy), acupuncture and acupressure. Some remedies may have adverse effects and may interact with medication.

Pharmacological

  • Non-steroidal anti-inflammatory drugs (NSAIDs) - these are the most commonly used drugs for the treatment of dysmenorrhoea due to their inhibition of prostaglandin synthesis. This is a class effect and all NSAIDs appear equally effective.[1] Ibuprofen is most often used due to its low incidence of side-effects. Although licensed specifically for dysmenorrhoea, there are concerns that mefenamic acid is more likely to induce seizures in overdose and has a low therapeutic window increasing the risk of accidental overdose.[6]
  • Weak opioids - there is no evidence of beneficial effect and the potential for addiction means they are not recommended.

Hormonal treatments
If the woman with dysmenorrhoea does not wish to conceive, offer her hormonal contraception. Ovarian suppression appears to control cyclical pelvic pain, whether or not caused by endometriosis. Adolescents and young adults who do not respond to hormonal treatment after three months should be evaluated for secondary causes of dysmenorrhoea.[8]This is likely in approximately 10% of patients.

  • Combined hormonal contraception (CHC) is often used. Despite the common use of oral CHC in the treatment of dysmenorrhoea (and guidance from the Faculty of Sexual and Reproductive Healthcare stating it can be used for this purpose from the menarche[9]), previous evidence has been inconclusive, due to a lack of randomised control trials.[10] However, CHC can also be used to increase cycle length by tricycling and hence reduce the frequency of the menses and therefore the symptoms.[11]
  • Oral progestogen-only contraception may also be used. In a study of 406 women with dysmenorrhoea who were given desogestrel 75 micrograms/day (Cerazette®), the pain resolved or improved considerably in 93% and, despite a high incidence of adverse effects, mainly bleeding irregularities, 90% were satisfied.[12]
  • Depo-medroxyprogesterone acetate (Depo-Provera®) is also sometimes used, as many women become amenorrhoeic within a year of starting treatment.
  • The levonorgestrel-containing intrauterine system (LNG-IUS; Mirena®) has been shown to reduce the severity of dysmenorrhoea despite not being anovulatory.[3]It could also be considered, even in adolescents.[13]Neither the 52 mg LNG-IUS (Mirena®) nor the newer 13.5 mg LNG-IUS (Jaydess®) is licensed for the treatment of dysmenorrhoea; Jaydess® is less likely than Mirena®to lead to amenorrhoea.[14].
  • Danazol is rarely used now and only under specialist supervision in the treatment of severe refractory cases.
  • Leuprolide acetate may be used in rare cases to suppress the menstrual cycle, but has a significant side-effect profile.

Surgery

  • Laparoscopic uterine nerve ablation (LUNA) has been used for the treatment of severe refractory cases; however, a Cochrane meta-analysis concluded that there is insufficient evidence of its effectiveness and it is not recommended.[15, 16]
  • Hysterectomy. In severe refractory cases, particularly in women who feel they have completed their families, hysterectomy may be considered.

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Original Author:
Prof Cathy Jackson
Current Version:
Dr Jacqueline Payne
Peer Reviewer:
Prof Cathy Jackson
Document ID:
2079 (v23)
Last Checked:
12 December 2014
Next Review:
11 December 2019

Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. Patient Platform Limited has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.