Laurence-Moon Syndrome

Authored by Dr Colin Tidy, 24 Feb 2015

Reviewed by:
Dr Adrian Bonsall, 24 Feb 2015

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Synonyms: adipogenital-retinitis pigmentosa syndrome, LM syndrome

This is a rare autosomal recessive condition.

Laurence-Moon-Biedl syndrome and Laurence-Moon-Biedl-Bardet syndrome are no longer considered valid terms, because the patients of Laurence and Moon had paraplegia, but no polydactyly or obesity, which are the main characteristics of Bardet-Biedl syndrome.[1, 2]

These are:[3]

There are no treatments specific to this syndrome. Management of the features outlined above is multidisciplinary:

  • Ophthalmic support for worsening vision.
  • Endocrinology advice regarding short stature and hypogonadism. Growth hormone treatment may be useful.
  • Speech therapy.
  • Renal opinion.

Life expectancy is lower than that of the general population. Renal disease is a common primary or contributing cause of death.

  • John Zachariah Laurence (1829-1870) was a British ophthalmologist. He was a founder of the South London Ophthalmic Hospital, later known as the Royal Eye Hospital.
  • Robert Charles Moon (1844-1914) was born in Brighton and qualified in London. He emigrated to the USA in 1879, having been a surgeon at the South London Ophthalmic Hospital. He worked in Philadelphia.
  • Arthur Biedl (1869-1933) was an endocrinologist born in Hungary. However, he qualified in Vienna and later became professor at the Institute of Pathology in Vienna.
  • Georges Louis Bardet was a French physician born 1885. Very little is known about him, not even his date of death.

Further reading and references

  1. M'hamdi O, Ouertani I, Chaabouni-Bouhamed H; Update on the genetics of bardet-biedl syndrome. Mol Syndromol. 2014 Feb5(2):51-6. doi: 10.1159/000357054. Epub 2013 Dec 20.

  2. Bardet-Biedl Syndrome 1, BBS1; Online Mendelian Inheritance in Man (OMIM)

  3. Laurence-Moon Syndrome; Online Mendelian Inheritance in Man (OMIM)

Three weeks ago, I gave my boyfriend a hand job and he came on my jeans (on the leg part so I'm not concerned about that) some went on his hand and some went on my hand but we both wiped it off. I...

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