What is Wolff-Parkinson-White syndrome?
In Wolff-Parkinson-White (WPW) syndrome there is an extra connection (an accessory pathway) between the atria and ventricles. This means that as well as electrical impulses passing normally between the atria and the ventricles at the AV node, electrical impulses can also pass abnormally along the accessory pathway.
The accessory pathway in WPW syndrome is known as the bundle of Kent. It is a congenital problem which means that it is present from birth. The majority of people with WPW syndrome have no other heart abnormalities.
An electrical impulse that passes along the accessory pathway can arrive at the ventricles more quickly than normal. There is not the usual impulse delay that occurs at the AV node and no limiting of the electrical impulses that pass through. This can cause the heart rate to speed up. The accessory pathway can also sometimes transmit electrical impulses backwards from the ventricles to the atria.
So, in WPW syndrome, the normal electrical activity of the heart is disrupted. There is a risk of developing a fast heart rate (a tachycardia) from time to time and other heart rhythm disturbances (arrhythmias). WPW can lead to what is called a supraventricular tachycardia. Tachycardia is a heart rate over 100 beats per minute (bpm). 'Supra' means above and because the atria are above the ventricles, the tachycardia is supraventricular.
The common arrhythmia that occurs in WPW syndrome is a paroxysmal (intermittent) supraventricular tachycardia (SVT). Other arrhythmias that can also occur include atrial fibrillation (AF), atrial flutter and atrioventricular re-entrant tachycardia (AVRT). Rarely, another arrhythmia called ventricular fibrillation can develop.
How common is Wolff-Parkinson-White syndrome?
WPW syndrome probably affects somewhere between 1-3 in 1,000 people. It is more common in men. There does seem to be some genetic basis, as WPW syndrome can run in families. However, most cases of WPW syndrome occur in people with no known family history.
What are the symptoms of Wolff-Parkinson-White syndrome?
Symptoms are caused by the episodes of rapid heart rate (tachycardia). How often these episodes occur can vary from person to person. In some people, the rapid heart rate only ever occurs once or twice. In others, it can occur a few times per week. Each episode of tachycardia may last from less than a minute to a few hours. An episode of tachycardia may even last for a few days but this is rare.
Many people are not aware that they have WPW syndrome because their symptoms are mild or don't occur very often. If symptoms are present, some people first notice them during childhood. In others, they may not be obvious until middle age.
Symptoms can also vary from person to person. They can include a sensation of feeling, or being aware of, your heartbeat (palpitations) and mild dizziness or light-headedness. Chest pain or chest tightness can also sometimes occur.
In some people, symptoms can be more severe. For example, an episode of a very rapid heart rate (up to about 250 bpm) can occur. If your heart is beating this quickly, your blood pressure can drop because your heartbeats become less effective and this can lead to collapse (blackout). If your heart is beating very fast, this can also lead to a build-up of fluid in your lungs and shortness of breath. In extreme cases, your heart can stop beating altogether (a cardiac arrest). However, this is rare.
How is Wolff-Parkinson-White syndrome diagnosed?
- It may be diagnosed by doing a heart tracing (electrocardiogram, or ECG). There are classic changes on the ECG that can be seen in some people with WPW syndrome. One such ECG change is known as a delta wave. If you are having an episode of tachycardia, this can also be seen on an ECG.
- Occasionally, WPW syndrome may be picked up on a routine ECG recording done for another reason such as a medical check-up. Sometimes an ambulatory ECG may be suggested. This is an ECG recording device that you wear usually over a 24-hour period. It can monitor your heart whilst you are going about your normal activities.
See separate leaflets called Electrocardiogram (ECG) and Ambulatory Electrocardiogram (ECG) for more details.
- Special tests called electrophysiology studies may be carried out in some people. They can help to find the precise area in the heart where the accessory pathway is located.
What is the treatment for Wolff-Parkinson-White syndrome?
Treating an episode of rapid heart rate
- Many episodes of SVT soon stop on their own and no treatment is then needed. It is sometimes possible to stop an episode of SVT by simple measures, including drinking a cold glass of water, holding your breath or putting your face into cold water.
- However, if an episode of SVT lasts a long time or is severe, you may need to be admitted to hospital to stop it.
- Medicines which are given by injection into a vein will usually stop an SVT. Adenosine is often used. It works by blocking electrical impulses in the heart.
Electric shock treatment (cardioversion) is sometimes used to stop an episode of the rapid heart rate (SVT).
Prevention of episodes of rapid heart rate
- Most people diagnosed with WPW syndrome will be referred to a heart specialist (cardiologist). If you have no symptoms and are at low risk of complications you may need no treatment.
- Radiofrequency destruction (ablation) is the treatment of choice but if you don't want it or are not considered suitable, other options are available. Treatment options include the following.
- This treatment may be suitable for many people with WPW syndrome. It is usually the first treatment that is offered to those who have symptoms. It may even be considered in some people with no symptoms.
- A thin tube called a catheter is inserted into an artery near your groin through a small cut in your skin. The tube is passed from here up to your heart. When the tip of the tube reaches the small area in your heart that causes the fast heart rate (the accessory pathway), this area is destroyed using a type of energy called radiofrequency.
- When carried out, radiofrequency ablation can have very good results and can cure the condition in the majority of people.
Long-term treatment with a medicine may be advised in some people to prevent episodes of rapid heart rate. For example, for people who don't wish to have radiofrequency ablation, or in those where this has failed. One medicine used is called amiodarone.
This type of treatment used to be done more commonly in the past for WPW syndrome. It has now been replaced by radiofrequency ablation in most cases. However, heart surgery is still used in some cases - for example, in people in whom radiofrequency ablation has failed and who do not wish to take medication for the rest of their lives. The surgery is open heart surgery which aims to find and destroy the accessory pathway that causes the fast heart rate.
What is the outlook?
WPW syndrome can be life-threatening during an acute episode of SVT but the outlook (prognosis) is otherwise very good. Catheter ablation usually cures WPW syndrome but some patients aren't suitable for this treatment.
Further reading and references
Raviele A, Giada F, Bergfeldt L, et al; Management of patients with palpitations: a position paper from the European Heart Rhythm Association. Europace. 2011 Jul13(7):920-34. doi: 10.1093/europace/eur130.
Checking your pulse; British Heart Foundation
Symptoms, Diagnosis and Monitoring of Arrhythmias; American Heart Association, 2009
Camm AJ; Cardiac arrhythmias--trials and tribulations. Lancet. 2012 Oct 27380(9852):1448-51. doi: 10.1016/S0140-6736(12)61773-5.
Kireyev D, Fernandez SF, Gupta V, et al; Targeting tachycardia: diagnostic tips and tools. J Fam Pract. 2012 May61(5):258-63.
Sohinki D, Obel OA; Current trends in supraventricular tachycardia management. Ochsner J. 2014 Winter14(4):586-95.
Albert CM, Stevenson WG; The Future of Arrhythmias and Electrophysiology. Circulation. 2016 Jun 21133(25):2687-96. doi: 10.1161/CIRCULATIONAHA.116.023519.
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