Pregnancy Screening Tests

Authored by Dr Mary Harding, 30 Oct 2017

Patient is a certified member of
The Information Standard

Reviewed by:
Dr Jacqueline Payne, 30 Oct 2017

This leaflet discusses the routine screening tests that should be offered to all pregnant women in the UK.

A screening test aims to detect a disease or condition in the early stages before it causes significant problems, and where treatment can be offered. The potential benefits of a screening test should outweigh any possible risks from the test.

This leaflet lists routine screening tests which should be offered to all pregnant women in the UK. Most pregnant women have normal test results. A small number of tests are abnormal. In these cases further assessment and/or treatment can be offered which may prevent serious problems.

(Various other tests may also be offered in certain circumstances during pregnancy. For example, if you have symptoms which suggest a complication then other tests may be relevant. These are not discussed further.)

A midwife or doctor should discuss each test with you before it is done. You need to agree for the tests to be done. You can refuse to have a test if you do not want it.

Early on in your pregnancy your doctor or midwife will ask various questions about your general health, family history, social history, and about any previous pregnancies which you have had. Strictly speaking, this is not a test. However, it can raise issues which may need special attention during the pregnancy, which may prevent problems later in the pregnancy.

For example, if you have diabetes, or if you had pre-eclampsia in a previous pregnancy, you will need closer monitoring than usual during the pregnancy. If you have social or family problems such as domestic violence then you may need special help.

  • Weight and height. Early on in the pregnancy your doctor or midwife will check your weight and height. This is to see if you are significantly underweight or overweight which may increase the risk of developing problems during pregnancy. Usually, after then your weight or height need not be measured again during pregnancy.
  • Assessing the growth of the baby. This is done by by a midwife or doctor during routine antenatal checks. They use a tape to measure from the top of the growing womb (uterus) to the bone at the bottom of your tummy (pubic bone).
  • Blood pressure. This is measured regularly during routine antenatal checks. (Together with a urine test to detect protein, this screens for a complication of pregnancy called pre-eclampsia. See separate leaflet called Pre-eclampsia for details.)
  • Examination of the baby's position. At about 36 weeks of pregnancy a doctor or midwife will examine your tummy (abdomen) to feel the baby to detect if the baby is lying bottom down (breech). If so, treatment to turn the baby to a head down position may be considered.

If you are otherwise healthy, other physical examinations are not routinely done. For example, routine vaginal or breast examinations used to be done in the past, but are not necessary. (They may be done if you have symptoms which warrant examination.)

Urine is checked at antenatal checks using a simple dipstick test to detect:

  • Protein. Protein in the urine may indicate early pre-eclampsia.
  • Sugar (glucose) as an initial check for diabetes.
  • Germs (bacteria). During pregnancy you can have an infection of the urine without symptoms (asymptomatic bacteriuria). This can increase the risk of problems later in pregnancy, such as early childbirth. It can be treated with antibiotic medication.

A sample of blood is taken early on in pregnancy and put into several tubes. These are sent to the laboratory to check for:

  • Anaemia. The common reason for anaemia is lack of iron, which can usually be treated easily with iron tablets.
  • Blood group including rhesus D status and red cell antibodies. If you are rhesus D negative and your baby is rhesus positive then you may form anti-D antibodies in your bloodstream. These are not dangerous in the first pregnancy, but can attack the blood cells of a baby who is rhesus D positive in any future pregnancy. To prevent this you will usually be offered anti-D injections later in your pregnancy. Various other antibodies sometimes develop against red cells. Their significance varies and a doctor or midwife will explain if any action should be taken if they are detected.
  • Rubella status. This test checks for antibodies to German measles (the rubella virus). If antibodies are present it means that you are immune to this infection. If you are not immune, when you are pregnant you should keep away from anyone who may have rubella. You should also consider being immunised against rubella after giving birth, to protect future pregnancies. (If a pregnant mother develops rubella it can seriously damage the baby. Ideally, your rubella status should be checked before becoming pregnant so that, if necessary, you can be immunised before becoming pregnant.)
  • Haemoglobin disorders. The blood test can detect if you're a carrier of sickle cell, thalassaemia or another haemoglobin disorder.
  • Infections. Some uncommon but serious infections are checked for. These are:
    • HIV. You can be infected with HIV for years before it causes symptoms. The risk of passing this virus on to your baby can be greatly reduced with treatment during pregnancy, and delivery by caesarean section.
    • Hepatitis B. Many people are carriers of the hepatitis B virus but have no symptoms. In some cases it can cause serious liver damage. If you have this virus, it may be prevented from affecting your baby if the baby is immunised at birth.
    • Syphilis. This is an uncommon sexually transmitted infection. Again, you can be infected with this germ (bacterium) without realising and pass it on to your baby. It can develop into a serious illness. It can be treated with antibiotics.
  • Diabetes. If you have had a history of diabetes in a previous pregnancy (gestational diabetes) then you will be tested for diabetes by a blood test in future pregnancies. In addition, you may be offered a test for diabetes if you have risk factors for diabetes; for example, if you :
    • Are obese.
    • Have had a heavy baby in the past (≥4.5 kg).
    • Have a close family relative with diabetes.
    • Are from certain ethnic groups.

A repeat blood test at about 28 weeks is usually offered to re-check for anaemia and red cell antibodies.

An ultrasound scan is a safe and painless test which uses sound waves to create images of structures inside your body, such as an unborn baby. Two scans are normally offered:

  • An early pregnancy scan works out when your baby is due. The scan is usually done at around 10-13 weeks.
  • A fetal anomaly scan is offered later in your pregnancy. The scan is usually done at around 20 weeks. This looks for any development problems with your baby. There are variations across the UK as to exactly when and how fetal anomaly scanning is done. Full details can be found at the UK Screening Portal (see below).

Down's syndrome is a genetic chromosome problem that some people are born with. Genetic means that the condition is passed on through families through special codes inside cells called genes. A person with Down's syndrome can usually be recognised by their typical features. It can also cause learning disability and there are certain medical problems. Someone with Down's syndrome has an extra copy of chromosome number 21 in the cells of their body. There are different screening tests for Down's syndrome and so different tests may be used in different areas of the country. They include a blood test and a special test using sound waves (an ultrasound scan), or both. Screening for Down's syndrome is offered between 10 and 20 weeks of pregnancy, depending on the type of test used.

Your doctor or midwife will explain the type of test performed in your area, and the implications of the results. For example, some women opt for termination of pregnancy if they are found to have a Down's syndrome child. The results of a screening test will provide you with information on the risk of your unborn baby having Down's syndrome. It does not give you a definite diagnosis or a definite answer. Only diagnostic tests will give you a definite answer (these are amniocentesis and chorionic villus sampling).

You do not have to have a screening test for Down's syndrome if you do not want one. See separate leaflet called Prenatal Screening and Diagnosis of Down's Syndrome for more details.

Placenta previa means that the placenta is covering the opening from the womb (uterus) to the neck of the womb (cervix). This can cause serious problems during childbirth. If an earlier scan using sound waves (an ultrasound scan) indicates that you may have a placenta previa, a repeat scan at 36 weeks of pregnancy may be advised. This is to clarify the position of your placenta before delivery.

The above tests are the usual routine tests offered to all pregnant women. If you have symptoms or problems which suggest pregnancy complications, various other examinations and tests may be advised. See your midwife or doctor if you have any concerns about your pregnancy, or if you wish to discuss any tests in more detail.

Further reading and references

I am currently in SE Asia and have been paranoid for nearly 3 months that im pregnant - I have taken around 15 pregnancy tests which have all come back negative but i still wasnt convinced! So today...

Health Tools

Feeling unwell?

Assess your symptoms online with our free symptom checker.

Start symptom checker