Right Upper Quadrant Pain - Common causes

What are the most common causes of right upper quadrant pain?

Gallstones and gall bladder problems

Gallstones don't necessarily cause any symptoms, but when they get stuck they can give you pain. This is called biliary colic and is typically a severe crampy pain in the right upper quadrant (RUQ) shortly after eating a fatty meal. An infection may ensue, called cholecystitis, which will give you a more persistent pain in the RUQ, with a high temperature (fever).

See separate leaflets called Gallstones and Cholecystitis for more information.

Kidney stones and infections

Problems with the kidney tend to give you pain more around the right-hand side of the RUQ, or in your back (loin), but the pain may spread and involve the front of the tummy (abdominal) area. Kidney stones can cause a severe pain (usually round the back) which occurs in spasms lasting from a few minutes to several hours. There may be also be blood in your wee. A kidney infection can cause pain anywhere along your urinary tract. So this could be anywhere from the loin in your back, around to the front, the RUQ, or down to the lower part of your tummy. It may be associated with a fever, pain when you wee, or going to the loo more frequently.

See separate leaflets called Kidney Infection (Pyelonephritis) and Kidney Stones for more information.


In some cases you can get the pain from shingles before the rash appears. You may have pain for a few days before a blistery rash appears. The pain tends to be quite sharp or burning, and you may feel not quite right in yourself. The RUQ is a common place for a shingles rash.

Other people find they continue to get a pain long after the rash of shingles has gone. This is called postherpetic neuralgia.

See separate leaflet called Shingles (Herpes Zoster) for more information.

Liver problems

The liver takes up a large part of your RUQ but, in fact, it doesn't very often give you pain. Causes of pain from the liver include:

  • Infection of the liver (hepatitis). This will usually result in jaundice and a fever and feeling generally unwell in addition to some pain in that area. Pain is not necessarily a feature. There are a number of types of hepatitis, including hepatitis A, hepatitis B and hepatitis C.
  • Abscess. This is a collection of pus around the liver or under the ribs, causing pain, tenderness and fever.
  • Alcoholic liver disease. Too much alcohol can damage your liver, which may affect its function, turn your skin yellow and give you RUQ pain.
  • Liver cancer - this can start in the liver or have spread from other cancers. Primary cancer in the liver is unusual. The liver may enlarge in certain blood cancers, such as lymphomas or leukaemias, causing discomfort.

Gut problems

Several problems with your guts can give you pain in the RUQ. For example:

What are the most common causes of right upper quadrant pain in pregnancy?

Any of the above conditions can cause pain in the RUQ whether you are pregnant or not, so you should always get checked out. However, in pregnancy a common cause of discomfort is the sheer pressure of the womb pressing on other organs, and pressing them into the diaphragm. Also, problems with indigestion tend to be common in pregnancy, again at least partly due to the pressure on the stomach. Urinary tract infections are also more common in pregnancy.

What are the most common causes of right upper quadrant pain in children?

In young children it is often quite difficult for them to show exactly where the pain is. If this is the case, the field of options widens to almost any cause of tummy ache. In children common causes include:

  • Constipation.
  • Anxiety.
  • Gastroenteritis.
  • Mesenteric adenitis. In children with infections such as colds, glands within the tummy commonly become inflamed giving them tummy ache.
  • Appendicitis. Usually this gives pain in the lower right part of the tummy. However, if a child can't show you exactly where the pain is, or if the appendix has burst (ruptured), appendicitis may be a possible diagnosis to consider.
  • Pneumonia. Infections of the lower parts of the lungs may cause pain in the tummy area.

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  • Kim JS; Acute Abdominal Pain in Children. Pediatr Gastroenterol Hepatol Nutr. 2013 Dec 16(4):219-224. Epub 2013 Dec 31.
  • Wilcox CM; Sphincter of Oddi dysfunction Type III: New studies suggest new approaches are needed. World J Gastroenterol. 2015 May 21 21(19):5755-61. doi: 10.3748/wjg.v21.i19.5755.
  • Cholecystitis - acute; NICE CKS, January 2017 (UK access only)
  • Gallstones; NICE CKS, February 2015 (UK access only)
  • Ahmed F, Fogel EL; Right upper quadrant pain and a normal abdominal ultrasound. Clin Gastroenterol Hepatol. 2008 Nov 6(11):1198-201. doi: 10.1016/j.cgh.2008.06.020.
  • Cartwright SL, Knudson MP; Diagnostic imaging of acute abdominal pain in adults. Am Fam Physician. 2015 Apr 1 91(7):452-9.
Dr Mary Harding
Peer Reviewer:
Dr Adrian Bonsall
Document ID:
29408 (v1)
Last Checked:
08 July 2017
Next Review:
07 July 2020

Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. Patient Platform Limited has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.