Can I take 2.5mg and Rinvoq together?
Drug interaction guide
Originally published 12 May 2026
Meets Patient’s editorial guidelines
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Taking Rinvoq (upadacitinib) with cannabis can increase the amount of Rinvoq in your bloodstream. This may increase your risk of experiencing side effects from the medication, such as infections, nausea, or changes in your blood counts. Additionally, both substances can affect your liver; using them together may put extra strain on liver function.
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Why this happens
Rinvoq is broken down in the liver by an enzyme called CYP3A4. Cannabis (specifically CBD and THC) can block this enzyme, slowing down how quickly your body clears Rinvoq. This leads to higher levels of the medicine in your system than intended.
What you should do
Back to contentsYou should speak to your doctor or specialist before using cannabis with Rinvoq. They may need to monitor your liver function and blood counts more closely. It is also important to remember that in the UK, it is illegal to drive with any cannabis in your system, regardless of whether you feel impaired.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
12 May 2026 | Originally published
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