Mental health research
Studies on depression, anxiety, ADHD, PTSD, bipolar disorder and more.
501 indexed studies · 288 currently recruiting
Top conditions in this hub
- Depression55
- Anxiety40
- Schizophrenia39
- Mental Health22
- Treatment-resistant Depression16
- Bipolar Disorder16
- Depression - Major Depressive Disorder13
- Psychosis11
- ADHD11
- Major Depressive Disorder10
- Psychotic Disorders9
- Mental Health Issue8
- Mental Disorders8
- Neurodevelopmental Disorders8
- Depressive Disorder8
- Focal Segmental Glomerulosclerosis7
Recent studies
- Recruiting
AI-based mobile apps for supporting adolescents’ mental health in schools
This study looks at how a smartphone app called MindCraft, which uses AI, can help teenagers in schools with their mental health. It aims to see if personalised tips from the app can make a difference compared to standard advice or just tracking feelings.
United Kingdom · England - Recruiting
Augmented depression therapy adapted for treating depression in adults with autism
This study looks at a new talking therapy called ADepT for autistic adults with depression. It aims to reduce low mood and help build wellbeing. Researchers want to see if it's safe and effective for autistic people before doing a larger study.
United Kingdom · England - Completed
The effects of helping and supporting an adult who experienced harm in the NHS and/or social care
This study looks at how people who care for a family member or friend are affected when their loved one is somehow harmed within the NHS or social care. Researchers want to understand their experiences and needs to improve support for carers in similar situations.
United Kingdom · England - Recruiting
SMILE: Supporting mental health in young people: integrated methodology for clinical decisions and evidence-based interventions
The SMILE study helps young people (10-24) with anxiety or depression. It uses a fun online game and activities to build resilience and improve mental health. The study runs from February 2025 to July 2026 across seven countries, including the UK.
United Kingdom · Scotland · Germany - Ongoing, recruitingTherapeutic exploratory (Phase II)
A multicenter, randomized, double-blind, parallel group, placebo-controlled study to assess the efficacy, safety, tolerability, pharmacokinetics and pharmacodynamics profile of BI 764198 administered orally once daily for 12 weeks in patients with focal segmental glomerulosclerosis.
This study is looking into a new medicine, BI 764198, for people with a kidney condition called focal segmental glomerulosclerosis. We want to see if it helps reduce protein in the urine and if it's safe to use, compared to a dummy pill.
Belgium · Spain · Germany - Recruiting
Cash for families
This study looks at whether giving money to families involved with social services can help improve children's mental health and wellbeing. Families either get extra financial support or continue with usual services. Researchers want to see if this helps reduce stress and improve home life.
United Kingdom · England - Ongoing, recruitingTherapeutic exploratory (Phase II)
An adaptive, randomized, placebo-controlled, double-blind study to evaluate the safety and efficacy of RL-007 in the treatment of cognitive impairment associated with schizophrenia (CIAS)
This study is looking into a new medication called RL-007 to help people with schizophrenia improve their thinking, learning, and memory skills. It's a key step to see if RL-007 is safe and effective.
Poland · Bulgaria · Czechia - Recruiting
A study to test whether a new website, Sleep Buddy, developed by doctors and psychologists, can help parents and carers of children aged 6-12 years with a diagnosis of ADHD who are experiencing sleep problems to improve their child’s sleep
This study looks at whether a new website called Sleep Buddy can help parents of children aged 6-12 with ADHD improve their child's sleep. Many children with ADHD struggle with sleep, which can affect their daily lives. The website offers advice and tips.
United Kingdom · England - Recruiting
How effective are walk-in mental health centers for young people with psychological distress in Europe and Australia?
This study looks at how well 'walk-in' mental health centres, called YEAHs, help young people aged 12-25 with mental health challenges. It checks if they improve mental well-being, are easy to use, and offer good value, comparing them to usual care.
United Kingdom · England · Australia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
An open label, single arm, extension trial to examine long-term safety of Iclepertin once daily in patients with schizophrenia who have completed previous Iclepertin Phase III trials.(CONNEX-X)
This study is looking at the long-term safety of a new medicine called Iclepertin for people with schizophrenia. It's for those who have already taken part in earlier studies of this medicine. We want to see how safe it is over a longer period.
Netherlands · Croatia · Finland - Recruiting
Effectiveness and public health impact of SELFIE, a blended ecological momentary intervention for improving self-esteem in young people
This study aims to help young people aged 14-25 in the UK and other European countries who have had tough childhoods and now have low self-esteem and mental health problems. It tests a program called SELFIE, combining an app with support from a mental health expert, to see if it can boost self-esteem.
United Kingdom · England · Estonia - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
In vivo PET of synaptic density in cognitive disorders: prospective evaluation of neuronal dysfunction and relation to symptomatology.
This study uses special brain scans to look at how brain connections (synapses) are affected in people with memory problems and other brain conditions. We want to understand why these conditions happen and how they lead to symptoms, hoping to find better ways to help in the future.
Belgium - Completed
Wait Less; an online brief psychological intervention to reduce waiting list distress
This study looks at whether an online talking therapy, MyMindWorks (MMW), can help young people aged 12-17 with depression while they wait for NHS mental health services. It aims to see if MMW is helpful and acceptable, and if it could reduce waiting list distress.
United Kingdom · England - Recruiting
Who Fares Best With Mindfulness Meditation
This study looks at how mindfulness meditation affects different people. It aims to find out who benefits most and who might experience problems. Researchers want to understand why mindfulness works for some and not for others, especially those with past trauma or negative thinking.
Belgium · United Kingdom - Recruiting
Visual Frailty in Ageing
This study looks at 'visual frailty' in older people with a common eye condition called AMD. Researchers want to understand and measure how vision problems, general health, and mental well-being are linked, to help improve care for ageing eyes.
United Kingdom - Recruiting
Supporting honest and reflective engagement after Mental Health Act assessments
This study wants to improve how people are supported after a Mental Health Act assessment. It aims to create a new way for patients and staff to talk about the experience, helping patients feel heard and prevent future compulsory hospital stays.
United Kingdom · England - Ongoing, recruitingTherapeutic use (Phase IV)
Efficacity of hypnosis versus premedication for the management of perioperative anxiety in gynecological surgery
This study looks at whether hypnosis before gynaecological surgery can help reduce anxiety better than usual pre-surgery calming medicines. It's for adult women and aims to find out the best way to help patients feel more relaxed before an operation.
France - Ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
An open label, balanced, randomized, two-treatment, two-period, two-sequence, single dose crossover bioequivalence study comparing Lamotrigine Dispersible Tablets BP 100 mg, manufactured by Sun Pharmaceutical Industries Limited, India with Lamictal (Lamotrigine) Dispersible Tablets 100 mg, Manufactured by: Delpharm Poznaÿ – Poland & Registered and Imported by: GlaxoSmithKline Brasil Ltda, in healthy adult, human subjects under fasting condition.
This study compares two different versions of a medicine called lamotrigine, used for epilepsy and bipolar disorder. Researchers want to see if a new tablet works the same way as an existing one, by giving single doses to healthy adult volunteers.
Romania - Ongoing, recruitingTherapeutic confirmatory (Phase III)
An Open-label Extension Study to Assess the Long-term Safety and Tolerability of Adjunctive KarXT in Subjects with Inadequately Controlled Symptoms of Schizophrenia
This study is looking at the long-term safety of a new medicine called KarXT for people with schizophrenia. It's a follow-up to earlier studies, helping us understand how safe it is when used for a longer time, and if there are any side effects.
Bulgaria - Ongoing, recruitingTherapeutic exploratory (Phase II)
AMIND - AMIloride for the treatment of Nephrogenic Diabetes insipidus for patients with bipolar disorder treated with lithium: a randomized controlled trial
This study looks at a medicine called amiloride for people with bipolar disorder who take lithium. Lithium can sometimes cause a kidney problem called nephrogenic diabetes insipidus, which makes you very thirsty and pass a lot of urine. We want to see if amiloride can help reduce these symptoms.
France - Recruiting
A study of home-use brain stimulation to treat bipolar depression
This study looks at whether a home-use device using mild electrical current can help people with bipolar depression. It aims to see if it's effective, safe, and easy to use at home, compared to a dummy treatment.
United Kingdom · England · Wales - Active not recruitingPHASE3
A Study of Different Donanemab (LY3002813) Dosing Regimens in Adults With Early Alzheimer's Disease (TRAILBLAZER-ALZ 6)
This study is looking at different ways of giving a medicine called donanemab for early Alzheimer's disease. Researchers want to see how different doses affect side effects and which patients might be more likely to experience them. It's for adults aged 60-85.
United States · United Kingdom - Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
Phase I, first-in-man, randomised, placebo-controlled, single dose escalation study to investigate the effects of LPH-5 on safety, tolerability, pharmacokinetic and pharmacodynamic parameters in healthy participants
This study is looking at a new medicine called LPH-5 for depression. It's the first time we're testing it in people to see if it's safe, how much the body absorbs, and what it does. Healthy adults will be involved.
France - Recruiting
Arts for the Blues for children and young people aged 9-13 years
This study looks at a creative therapy called 'Arts for the Blues' for 9-13 year olds with depression and anxiety. It uses activities like drawing and movement to help children explore their feelings and improve their mental wellbeing when receiving NHS mental health support.
United Kingdom · England - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Multicenter, Double-blind, Parallel, Active-control Study of the Effects of Sparsentan, a Dual Endothelin Receptor and Angiotensin Receptor Blocker, on Renal Outcomes in Patients with Primary Focal Segmental Glomerulosclerosis (FSGS)
This study is testing a new medication called Sparsentan for people with a kidney condition called FSGS. It compares Sparsentan to an existing treatment (Irbesartan) to see how well it protects the kidneys and if it's safe over about two years.
Germany · Belgium · France - RecruitingNA
Using Mentalization Based Therapy to Support Children and Adolescents Referred to Specialist Mental Health Services in the NHS for Aggressive and/or Violent Behaviour
This study looks at a new type of support called mentalisation-based therapy (MBT) for young people aged 10-17 in NHS mental health services who show aggressive or violent behaviour. It aims to see if MBT, which helps young people understand their feelings and actions, works better than usual care.
United Kingdom - Enrolling by invitation
DENTOFACIAL-PBT Stage 2 - Feasibility Study
This study looks at how proton beam therapy for childhood head and neck cancer might affect teeth and jaws. Researchers want to understand these side effects better to improve future care for young patients in the UK.
United Kingdom - RecruitingPhase I
A study to evaluate the safety of NTX-1955 in patients with generalised anxiety disorder
This study is testing a new drug, NTX-1955, for generalised anxiety disorder (GAD). We want to see if it's safe and how people react to it. Participants will take the drug or a dummy pill for two weeks.
United Kingdom - Ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A randomized, two-way, crossover, two parallel groups study to compare the bioavailability of 150 mg and 300 mg trazodone hydrochloride tablets (new polymer) (Angelini Pharma S.p.A.) vs. 150 mg and 300 mg trazodone hydrochloride Contramid® tablets (Angelini Pharma S.p.A.) at steady-state
This study compares how two different versions of trazodone tablets, a medicine for depression, are absorbed by the body. Researchers are looking at new tablets versus existing ones to see if they work similarly. It involves healthy volunteers and is a very early stage of research.
Germany - AuthorisedHuman Pharmacology (Phase I)- Other
Unraveling the aesthetic mind in anhedonia, insights from pharmacological imaging of the human brain: A single-blind, randomized, placebo-controlled cross-over study
This study looks at how people with depression experience beauty and art, and how a new treatment might affect these feelings. It’s a very early-stage trial, comparing the treatment to a dummy pill in adults.
Austria - RecruitingPHASE3
A Study to Find Out if BI 764198 Helps Adults and Adolescents With a Kidney Condition Called Focal Segmental Glomerulosclerosis (FSGS)
This study looks at a new medicine, BI 764198, for people aged 12 and over with a kidney condition called FSGS. It aims to see if this medicine helps improve kidney health. Participants will take a tablet daily and have their kidney function checked regularly.
United States · Argentina · Australia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Double-Blind, Oral, Placebo-Controlled, Multiple-Dose, Parallel, Randomized Study to Evaluate Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients
This study is testing a new medicine, Endoxifen, for people with Bipolar I Disorder. Researchers want to see if it helps improve symptoms of mania and is safe to use. It compares Endoxifen to a look-alike dummy pill in adults.
Romania - Recruiting
CBT and the Neural Circuits of Anxiety
This study looks at how a talking therapy called CBT changes the brain in people with anxiety. It aims to understand why CBT works, hoping to make treatments even better and more personal for anxiety in the future.
United Kingdom - AuthorisedHuman Pharmacology (Phase I)- Bioequivalence Study
A Randomized, Multiple-Dose, Open-Label, Parallel-Group Study to Evaluate the Pharmacokinetic Profiles of LY03010 and the Relative Bioavailability at Steady-State of LY03010 versus XEPLION® in Patients with Schizophrenia
This study is looking at a new version of a medication for schizophrenia. It compares how this new version is handled by the body to an existing medication, to see if they work in a similar way after several doses.
Bulgaria · Croatia · Portugal - AuthorisedTherapeutic exploratory (Phase II)
OSU6162 in Bipolar Depression: An Open-label, Flexible Dose Study (OBID)
This study is looking into a new medication called OSU6162 for people with bipolar depression. It hopes to see if this medicine can help improve symptoms of depression. Participants will take the medicine, and doctors will monitor their mood over a couple of months.
Sweden - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Nitrous Oxide in Resistant Depression in Elderly Subjects: A Randomized, Double-blind, Comparator Trial
This study is testing if a gas mixture, similar to 'laughing gas', can help older people with depression that hasn’t improved with other treatments. Researchers are comparing it to regular air to see if it makes a difference to their mood.
France - AuthorisedTherapeutic exploratory (Phase II)
Targeting inflammation in depression using Minocycline: a patient stratification approach using peripheral inflammatory biomarkers and MRI
This study is looking at how a common antibiotic, Minocycline, might help people with depression. Researchers will see if it reduces inflammation in the body and if that helps improve mood. They'll also use brain scans to understand the changes.
Italy - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Adjunctive KarXT in Subjects with Inadequately Controlled Symptoms of Schizophrenia
This study is looking into a new medication called KarXT for adults with schizophrenia who aren't getting enough relief from their current treatments. It aims to see if KarXT can help reduce symptoms, compared to a dummy pill, over a 6-week period.
Bulgaria - Recruiting
Clinical trial of digitally enabled cognitive therapy for social anxiety disorder in NHS Talking Therapies for anxiety and depression services
This study looks at a new online therapy for social anxiety disorder in NHS Talking Therapies. It compares this internet-based treatment, where you learn at home with therapist support, to the usual face-to-face NHS treatments, to see which works best and if it helps more people.
United Kingdom · England - Ongoing, recruitingTherapeutic use (Phase IV)
PRECISER; Prediction of ECT treatment response and reduction of Cognitive Side-effects using EEG and Rivastigmine
This study looks at ways to improve depression treatment using ECT (electroconvulsive therapy). Researchers are testing a medication called rivastigmine to see if it can help reduce memory problems from ECT and predict who will respond best to the treatment.
Netherlands