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  1. Splenomegaly and Hypersplenism Professional

    Splenomegaly and Hypersplenism, Pancytopenia due to hypersplenism (see 'Hypersplenism' heading, below). Examination When considering whether an LUQ mass i...

  2. Autoimmune Lymphoproliferative Syndrome Professional

    Also: Splenectomy should be avoided except in cases of uncontrollable hypersplenism. However, rituximab and splenectomy are often the treatments of choice in refractory autoimmune cy...

  3. Chediak-Higashi Syndrome Professional

    Non-drug Abscesses are surgically drained when appropriate. [ 1 ] BMT appears to have been successful in several patients. [ 13 ] Complications Frequent infections lead to ...

  4. Chronic Hepatitis Professional

    Portal hypertension : ascites , hypersplenism , lower oesophageal and rectal varices. Hypoalbuminaemia. Coagulopathy. Osteoporosis .

  5. Cirrhosis Professional

    Anaemia, thrombocytopenia and coagulopathy [ 18 ] Anaemia may result from folate deficiency , haemolysis or hypersplenism . Thrombocytopenia is usually secondary to hyperspl...

  6. Hereditary Spherocytosis Professional

    Severe hypophosphataemia . Hypersplenism . ABO incompatibility (neonates). Investigations Most patients can be diagnosed on the basis of a family history, typical clinical ...

  7. Mastocytosis and Mast Cell Disorders Professional

    Haematological and bones: Anaemia or other cytopenias (if bone marrow involvement). Hypersplenism. Lymphadenopathy. Fractures (if bone marrow involved). Rarely, a bleeding di...

  8. Autosomal Recessive Polycystic Kidney Disease Professional

    Morbidity and mortality are usually due to portal hypertension, including variceal bleeding and thrombocytopenia or anaemia from hypersplenism. Mortality is the lowest of the four categori...

  9. Bone Marrow and Bone Marrow Failure Professional

    Differential diagnosis Systemic lupus erythematosus and hypersplenism - can cause pancytopenia with a normal bone marrow. Other causes of anaemia. Investigations [ 3 , 5...

  10. Childhood Anaemia Professional

    Disseminated intravascular coagulation . Hypersplenism . Anaemia due to blood loss Including gastrointestinal blood loss and heavy menstruation in girls.

  11. Haemolytic Anaemia (Causes, Symptoms and Treatment) Professional

    Non-immune: trauma (cardiac haemolysis, microangiopathic anaemia (found in patients with disseminated intravascular coagulation or haemolytic uraemic syndrome and thrombotic thrombocytopenic purp...

  12. Splenectomy and Hyposplenism Professional

    Spontaneous rupture: this usually occurs in patients with massive splenomegaly (eg, infectious mononucleosis) and is often precipitated by minor trauma. Hypersplenism: hereditary spherocyt...

  13. Autoimmune Hepatitis Professional

    Haematological: hypersplenism , autoimmune haemolytic anaemia , pernicious anaemia , immune thrombocytopenia, eosinophilia .

  14. Menstruation and Menstruation Disorders Professional

    Systemic disease disorders of blood clotting may therefore be a cause - eg, von Willebrand's disease or prothrombin deficiency, leukaemia, immune thrombocytopenia (ITP) and hypersplenism...

  15. Thalassaemia Professional

    Indications for regular transfusion include growth impairment and skeletal deformities. If hypersplenism develops, splenectomy may be considered, although this carries severe risks of life...

  16. Neutropenic Patients and Neutropenic Regimes (Neutropenia) Professional

    Accelerated neutrophil turnover in the blood: Felty's syndrome (rheumatoid arthritis, splenomegaly, and granulocytopenia). Hypersplenism. Malaria and acute bacterial infections...

  17. Non-Hodgkin's Lymphoma (Causes, Symptoms, and Treatment) Professional

    Differential diagnosis See also the separate Generalised Lymphadenopathy and Splenomegaly and Hypersplenism articles. Hodgkin's lymphoma . Acute or chronic leukaemia. ...

  18. Thrombocytopenia and Platelet Function Disorders Professional

    Splenomegaly and hypersplenism , which may be associated with a variety of conditions - eg, cirrhosis, malaria, lymphoma.

  19. Abdominal Examination (Preparation and Methods) Professional

    Look for purpura (may be present in hypersplenism or impaired clotting function). Look for spider naevi (liver disease). Xanthelasma (symmetrical yellow plaques around the eyelids...

  20. Aplastic Anaemia Professional

    Differential diagnosis Hypersplenism . Hypocellular myelodysplasia, acute myeloid leukaemia . Hypocellular acute lymphoblastic leukaemia .

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