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Did you mean: hyposplenism
Splenomegaly and Hypersplenism, Pancytopenia due to hypersplenism (see 'Hypersplenism' heading, below). Examination When considering whether an LUQ mass i...
Also: Splenectomy should be avoided except in cases of uncontrollable hypersplenism. However, rituximab and splenectomy are often the treatments of choice in refractory autoimmune cy...
Non-drug Abscesses are surgically drained when appropriate. [ 1 ] BMT appears to have been successful in several patients. [ 13 ] Complications Frequent infections lead to ...
Portal hypertension : ascites , hypersplenism , lower oesophageal and rectal varices. Hypoalbuminaemia. Coagulopathy. Osteoporosis .
Anaemia, thrombocytopenia and coagulopathy [ 18 ] Anaemia may result from folate deficiency , haemolysis or hypersplenism . Thrombocytopenia is usually secondary to hyperspl...
Severe hypophosphataemia . Hypersplenism . ABO incompatibility (neonates). Investigations Most patients can be diagnosed on the basis of a family history, typical clinical ...
Haematological and bones: Anaemia or other cytopenias (if bone marrow involvement). Hypersplenism. Lymphadenopathy. Fractures (if bone marrow involved). Rarely, a bleeding di...
Morbidity and mortality are usually due to portal hypertension, including variceal bleeding and thrombocytopenia or anaemia from hypersplenism. Mortality is the lowest of the four categori...
Differential diagnosis Systemic lupus erythematosus and hypersplenism - can cause pancytopenia with a normal bone marrow. Other causes of anaemia. Investigations [ 3 , 5...
Disseminated intravascular coagulation . Hypersplenism . Anaemia due to blood loss Including gastrointestinal blood loss and heavy menstruation in girls.
Non-immune: trauma (cardiac haemolysis, microangiopathic anaemia (found in patients with disseminated intravascular coagulation or haemolytic uraemic syndrome and thrombotic thrombocytopenic purp...
Spontaneous rupture: this usually occurs in patients with massive splenomegaly (eg, infectious mononucleosis) and is often precipitated by minor trauma. Hypersplenism: hereditary spherocyt...
Haematological: hypersplenism , autoimmune haemolytic anaemia , pernicious anaemia , immune thrombocytopenia, eosinophilia .
Systemic disease disorders of blood clotting may therefore be a cause - eg, von Willebrand's disease or prothrombin deficiency, leukaemia, immune thrombocytopenia (ITP) and hypersplenism...
Indications for regular transfusion include growth impairment and skeletal deformities. If hypersplenism develops, splenectomy may be considered, although this carries severe risks of life...
Accelerated neutrophil turnover in the blood: Felty's syndrome (rheumatoid arthritis, splenomegaly, and granulocytopenia). Hypersplenism. Malaria and acute bacterial infections...
Differential diagnosis See also the separate Generalised Lymphadenopathy and Splenomegaly and Hypersplenism articles. Hodgkin's lymphoma . Acute or chronic leukaemia. ...
Splenomegaly and hypersplenism , which may be associated with a variety of conditions - eg, cirrhosis, malaria, lymphoma.
Look for purpura (may be present in hypersplenism or impaired clotting function). Look for spider naevi (liver disease). Xanthelasma (symmetrical yellow plaques around the eyelids...
Differential diagnosis Hypersplenism . Hypocellular myelodysplasia, acute myeloid leukaemia . Hypocellular acute lymphoblastic leukaemia .