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    Paracetamol Poisoning Conditions

    A blood clotting test (called prothrombin time) is an earlier and better indicator of liver damage. Prothrombin time : as part of the blood clotting tests that will be requested,...

    Causes Symptoms Diagnosis Treatment

    Blood Clotting Tests Conditions

    For example, the 'prothrombin time' (PT) and the 'activated partial thromboplastin time' (APTT) are commonly done.

    Immune Thrombocytopenia Purpuric Rashes Antiphospholipid Syndrome Thrombophilia

    Abnormal Liver Function Tests Conditions

    What do abnormal prothrombin time and INR mean? Prothrombin time (PT) or International Normalised Ratio (INR) are sometimes measured as a part of standard liver function tests.

    Abnormal Liver Function Tests Professional

    Therefore, albumin levels have prognostic meaning in chronic liver conditions whilst clotting factors may compensate, leading to preservation of prothrombin time. Prothrombin time...

    Dubin-Johnson Syndrome Professional

    The urinary coproporphyrin level is raised with a specific increase in the ratio of coproporphyrin I to coproporphyrin III - a pathognomonic feature of Dubin-Johnson syndrome, as the former is usually...

    Vitamin K Deficiency Professional

    Investigations Bleeding time, prothrombin time and activated partial thromboplastin time are all elevated. The most sensitive marker is the antibody test for high l...

    Disseminated Intravascular Coagulation Professional

    If DIC is suspected then clotting screen tests are followed by confirmation: Prothrombin time (PT) elevated. Activated partial thromboplastin time (aPTT) elevated. Platel...

    Bleeding Disorders Professional

    Haemostasis tests in bleeding disorders [ 1 , 21 ]   Platelet count Prothrombin time Activated partial thromboplastin time Bleeding time...

    Hypervitaminosis Professional

    Studies have also shown an increase in all-cause mortality associated with vitamin E supplements. [ 9 ] Supplementation with vitamin E may also significantly increase the risk of prostate cancer a...

    Primary Sclerosing Cholangitis Professional

    Serum transaminase levels may be normal or elevated to several times normal. Bilirubin is raised in advanced PSC. Serum albumin and prothrombin time (PTT) become abnormal as th...

    Obstetric Cholestasis Professional

    Treatment - topical emollients are safe for both mother and baby but their efficacy is unproven. [ 1 ] Ursodeoxycholic acid (UDCA)  is the mainstay of medical management, with noted positive ef...

    Chronic Hepatitis Professional

    LFTs, serum albumin, prothrombin time. Immunoglobulins (IgG raised in autoimmune hepatitis; IgM raised in primary biliary cirrhosis).

    Paracetamol Poisoning Professional

    Clotting screen: prothrombin time is the best indicator of severity of liver failure and the INR should be checked 12-hourly.

    Protein S Deficiency Professional

    Coagulation tests: including APTT, prothrombin time, fibrinogen level, fibrin degradation, D-dimer test. Tests for other thrombotic risk factors, including antithrombin level, a plasma-bas...

    Vitamin C Deficiency Professional

    Bleeding, coagulation and prothrombin times are all normal. X-rays can assess for fractures and dislocations. They may also show subperiosteal elevation, alveolar bone reabsorption and gro...

    Tyrosinaemia Professional

    Differential diagnosis Fructose 1-6-diphosphatase deficiency Fructose 1-phosphate aldolase deficiency ( fructose intolerance ) Galactose 1-phosphate uridyltransferase deficiency ( galactos...

    Budd-Chiari Syndrome Professional

    Investigations [ 7 ] LFTs - these may show a mild elevation. Prothrombin time - this may be prolonged, which may be confusing if the condition is associated with a hypercoagulabilit...

    Primary Biliary Cholangitis Professional

    Increasing prothrombin time, elevated bilirubin and decreased albumin all point to the time being due [ 35 ] .

    Oral Anticoagulants Professional

    Initiation [ 2 , 11 ] Ideally, the baseline prothrombin time should be used to assess dosage but if the clinical situation requires it, initiation should not be delayed.

    Upper Gastrointestinal Bleeding (includes Rockall Score) Professional

    Fresh frozen plasma should be used for patients who have either a fibrinogen level of less than 1 g/L, or a prothrombin time (INR) or activated partial thromboplastin time greater th...

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