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    Splenomegaly and Hypersplenism Professional

    Splenomegaly and Hypersplenism, Myelofibrosis, malaria (hyper-reactive malarial splenomegaly). Leishmaniasis. 'Tropical splenomegaly' (idiopathic; Africa, Sout...

    Primary Myelosclerosis Professional

    There may be incidental finding with anaemia or splenomegaly. Fatigue and weakness (secondary to anaemia) are common presenting complaints. It may present as unusual bleeding.

    Felty's Syndrome Professional

    It is the triad of RA, neutropenia and splenomegaly. It was first described by Dr Augustus Felty in 1924. [ 1 ] Epidemiology Felty's syndrome only occurs in those patients with ...

    Myelofibrosis Professional

    B1: palpable splenomegaly. B2: unexplained anaemia. B3: leuko-erythroblastosis. B4: tear-drop red cells.

    Favism Professional

    Patients with G6PD deficiency are prone to gallstones and splenomegaly due to recurrent, often subclinical, episodes of haemolysis. Differential diagnosis Acute haemolysis cause...

    Hepatomegaly Professional

    With raised conjugated bilirubin: With splenomegaly: TORCH ( TO xoplasmosis,  R ubella,  C MV and  H erpes simplex) infections, sepsis and disorders of carbohydrate...

    Polycythaemia Vera Professional

    Synonyms: polycythaemia rubra vera, plethora vera, primary polycythaemia, Osler-Vaquez disease Polycythaemia vera (PV) is a clonal haematological malignancy characterised by pronounced symptoms,...

    Hereditary Spherocytosis Professional

    Epidemiology The reported incidence varies from 1 in 2,000 to 1 in 10,000. [ 3 ] Approximately 75% of cases display an autosomal dominant pattern of inheritance; the rest are recessive forms and de...

    Abdominal Masses Conditions

    Left upper quadrant Spleen : enlarged spleen (splenomegaly). There are many causes of an enlarged spleen, including leukaemia , lymphoma , thalassaemia , sickle cell disease , mal...

    X-linked Lymphoproliferative Syndrome Professional

    Abdomen : hepatomegaly, fulminant hepatitis and liver failure , splenomegaly . Haematological : atypical mononucleosis (lymphocytosis); thrombocytopenia or bone marrow failure .

    Infectious Mononucleosis Professional

    Later signs include: Mild hepatomegaly and splenomegaly (splenic enlargement returns to normal or near normal usually within three weeks after the clinical presentation) with tenderness ...

    Autoimmune Lymphoproliferative Syndrome Professional

    The clinical manifestations may be seen in other family members and include lymphadenopathy, splenomegaly, increased risk of lymphoma, and autoimmune disease, most often involving cells of th...

    Glucose-6-phosphate Dehydrogenase Deficiency Professional

    Back or abdominal pain (usually occurs when >50% haemolysis occurs). Splenomegaly may occur. Investigations FBC - anaemia. Macrocytosis - due to reduced folic acid whic...

    POEMS Syndrome Professional

    Organomegaly (splenomegaly, hepatomegaly or lymphadenopathy). Oedema (peripheral oedema, pleural effusion or ascites).

    Abdominal Masses Professional

    Causes of Abdominal Mass by Location Right upper quadrant Cholecystitis - very tender mass Cholangiocarcinoma - moderately tender, irregularly shaped mass Hepatomegaly ...

    Ehrlichiosis Professional

    There are no specific findings on clinical examination but mild hepatomegaly , lymphadenopathy and splenomegaly may occur. Differential diagnosis Any cause of an influenza...

    Childhood Anaemia Professional

    Left upper quadrant pain (if there is associated splenomegaly). Right upper quadrant pain (secondary to cholelithiasis in haemolytic anaemia).

    Niemann-Pick Disease Professional

    It usually presents with splenomegaly, first noted in childhood. Other features include hepatosplenomegaly, bone and haematological involvement, limb and joint pain, growth delay in adoles...

    Generalised Lymphadenopathy Professional

    Perform a systematic examination to exclude signs of obvious malignancy and especially the abdomen to exclude hepatomegaly or splenomegaly. Bilateral anterior cervical lymph nodes up to...

    Purpuric Rashes Professional

    Review Having inspected the skin and taken a history, it may be useful to return to a physical examination to reassess the rash and carry out a further systemic examination, looking for hepatomegal...

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