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    Myelofibrosis Conditions

    Treatment will also be needed for the effects of reduced production of blood cells such as anaemia. Thalidomide and other similar medicines (lenalidomide and pomalidomide) may also help to...

    Sarcoidosis Conditions

    Infliximab thalidomide and tetracyclines

    Photodermatoses Professional

    Antimalarials and thalidomide may also be used. [ 11 , 12 ] Hydroa vacciniforme This is a rare childhood photodermatosis with recurrent papules, vesicles and crusts occurring on su...

    Goldenhar's Syndrome Professional

    Aetiology Ingestion of drugs such as thalidomide, retinoic acid, tamoxifen and cocaine by pregnant mothers may be related to the development of Goldenhar's syndrome.

    Primary Myelosclerosis Professional

    [ 3 ] Thalidomide was thought to give a good response in 20-60%, [ 4 ] but a recent Cochrane review showed that there was no substantial efficacy in anaemic myelosclerotic patients. [ 5 ] ...

    Paraproteinaemia Professional

    Autologous stem cell transplant can prolong survival. Thalidomide in combination with dexamethasone has an emerging role in the treatment of myeloma.

    Myeloma (Myelomatosis) Conditions

    These may include interferon, steroids, thalidomide, lenalidomide or bortezomib. This is, in effect, low-level chemotherapy which aims to keep you in remission for as long as possible.

    Leprosy Professional

    Severe type II reactions may require steroids. Thalidomide may be used for patients who have become dependent on steroids but should only be used only under specialist supervision.

    POEMS Syndrome Professional

    Lenalidomide - has been used with some success. [ 10 ] Thalidomide and bortezomib - may be effective but risk exacerbating peripheral neuropathy. The benefit of anti-VEGF antibodies is co...

    Polymorphic Light Eruption Professional

    Topical vitamin D analogues have been used with promising results. [ 13 , 14 ] Immunomodulators (eg, azathioprine or thalidomide) have been used in the past to treat photodermatoses; how...

    Itching Professional

    Rifampicin, opioid antagonists and selective serotonin reuptake inhibitors (SSRIs) are also used. Thalidomide and naltrexone (uraemia). Nalfurafine has been found effective for itch relate...

    Erythema Nodosum Professional

    In difficult cases, oral potassium iodide may be valuable, as may tetracycline and, in erythema nodosum of leprosy, thalidomide has seen a resurgence but further research is required [ 10 , ...

    Myeloma Professional

    The following management is currently recommended by NICE for people with newly diagnosed myeloma: Bortezomib in combination with dexamethasone, or with dexamethasone and thalidomide, i...

    Congenital Ear Problems Professional

    Anotia is rare but seen in 20% of children with thalidomide-induced abnormalities. Microtia (along with protruding ears) is the most common ear problem encountered in plastic surgery. [ 2 ] I...

    Behçet's Disease Professional

    Mucocutaneous lesions and joint involvement: These may respond to non-steroidal anti-inflammatory drugs, prednisolone, levamisole, colchicine, dapsone, or sulfapyridine and thalidomide. ...

    Prurigo Nodularis Professional

    One study reported that hypnosis and acupuncture were beneficial. [ 20 ] Systemic therapies These include: Antihistamines may help to control itch in some cases. Thalidomide...

    Amyloidosis Professional

    Trials with novel agents such as thalidomide, lenalidomide, pomalidomide and bortezomib have shown promising results. As AL amyloidosis is very similar to multiple myeloma, the chemotherap...

    Coloboma Professional

    Teratogenic drugs - thalidomide, mycophenolate mofetil. [ 5 ] Infections (toxoplasmosis, cytomegalovirus). Associated conditions Microphthalmia, anophthalmia and coloboma are an ...

    Myelodysplastic Syndromes Professional

    Modern DNA anti-methylating agents (azacitidine, decitabine), farnesyl transferase inhibitors (lonafarnib, tipifarnib) and immunomodulators such as lenalidomide (a thalidomide analogue effect...

    Myelofibrosis Professional

    Splenomegaly [ 1 ] First-line: hydroxycarbamide (in the absence of cytopenias). Thalidomide and prednisolone may be considered in the presence of cytopenias; lenalidomide may be consid...