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Anyone had to choose between different Lupus/RA drugs?

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kevin91306
kevin91306

My wife has been diagnosed by her rheumatologist with lupus-RA overlap. Already done several rounds of steroids and she is on Plaquenil. The doc prescribed weekly injections of Orencia; after the first shot she had a bad headache, fatigue and flu-like symptoms for several days. She is scared to take the next shot. The doctor says Orencia is her first pick of a drug to try, but could prescribe Actemra or Benlysta instead. She asked to choose between continuing with the Orencia injections weekly, switching to Orencia monthly infusion, weekly Actemra, or weekly Benlysta. Does anyone have any recommendations or thoughts on the (bad) initial reaction to Orencia? Will the side effects persist after multiple injections?

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