Peptides for Parkinsons

I am in the process of trying to help out a friend with PD. I've done some research and she is taking some of the regularly prescribed drugs and on most days she is doing well. Unfortunately none of these drugs really slow the advancement of PD. There have been recent studies to show that some peptides may do exactly that.

"There has been increasing interest in GLP-1 receptor agonists such as exenatide, liraglutide and lixisenatide as potential disease modifying agents in PD. GLP-1 receptors have been found throughout the brain. Systemic insulin resistance is thought to be associated with the onset of PD. Patients with PD usually have impaired glucose tolerance that can induce brain insulin resistance which is implicated in the neurodegenerative process. In preclinical models of PD, exenatide and other approved GLP-1 receptor agonists have demonstrated neuroprotective effects. Recently, a randomized, double-blind, placebo-controlled clinical study of exenatide in the treatment of PD, showed that patients using exenatide displayed better motor function compared to the placebo group (10). Additional clinical trials are underway to evaluate GLP-1 receptor agonists in patients with PD."

Now I realize that these are clinical trials but the trials take so long.

Has anyone tried to obtain these peptides from labs and seen if they work for them?

GLP-1 (7-37) is readily available for anyone to order I am just not sure that it is the same as the peptides used for the trials. I will do more research but I am curious how far people have gone to try to slow this down.

Thanks for any help you can offer.

KC

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