Venlafaxine & Mirtazapine stopped working after 8 weeks

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Hi All,

I really hope you can help. I had an anxiety relapse in May 22 that I tried to get over using my usual regimen of Venlafaxine 75mg. I have been using Venlafaxine 75mg when needed for 10-11 years without much incident, where I could increase to Venlafaxine 75mg when anxiety episodes happened and reduce to a therapeutic level of 37.5 when they abated (generally after 8 weeks). This last episode didn't follow that pattern, and I have now been through the rollercoaster of trying to find the right treatment combo to get .

I have been on Venlafaxine 112.mg and Mirtazapine 30mg for eight weeks. This initially led to a remarkable recovery where I have been relatively anxiety free (80-90%) for this time. This week has seen a return to pre Mirtazapine symptoms (jitteryness, racing thoughts, brain fog). Its not helping sleep much nor is to giving me the carb cravings that I got used to.

Is it possible Mirt has stopped working after 8 weeks? Could I have developed a tolerance? Or do I need to give this a bit longer to see if its a blip.

Thank you in advance,

RT

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