Androgen Insensitivity Syndrome
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Anyone has come across a person who has Intersex, "someone who has physical female genatalia but acts like a man", also known as "Androgen Insensitivity Syndrome". What are their mental make up and behaviour and other physical qualities?
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josie07889 rocky31676
Posted
I have what is referred to as Grade 2 PAIS. The grades of AIS are made by genital appearance only. In my case a subcoronal hypospadias with split penial raphe. In other words my urethra is closed by only a layer of skin. I also had a partially unfused perinial raphe when I was born. This today looks like a scar but I do remember at 4-5 it was still painful to touch.
AIS is associated with mutations of the Androgen Receptor encoding Gene (AR gene). The medical database has over 600 known mutations as of 2017 for this gene.
Grade 1 AIS is more common than realized. Most men carrying this level of mutation don't know it. It is only diagnosed if checking for male infertility.
Grade 2- Grade5 are seen often at birth. Hypospadias are often repaired in the same surgery as circumcision. When the higher Grades are seen the parents have in the past been told which type of genital reconstruction the doctor thought the baby should have. They parents were then told to raise the child in the gender matching the surgery. This was following a later cometely disproven idea that gender was based on forced roles enforced by the parents. A discredited phsychologist named Dr. Money spent decades speaking to his theory. This is now known completely false.
Grade 6-Grade 7 AIS are considered Complete AIS because the person has full female exterior genitals at birth. Inside they do not have ovaries or an uterus so they are born with a short blind vaginal opening. They have tested inside their bodies. Their tested make testosterone but do not react to it. This excess testosterone is converted into estrogen. In puberty they grow just like any XX gilr does. A grade 6 CAIS girl will grow pubic hair. A grade 7 CAIS will not as she will have absolute zero ability to react to androgens of all types.
What is interesting to note is the gender identity. Grade1 men have always reported identifying as males. Grade 2- Grade 5 are split identifying between male and female. Medical studies have reported no way to predict the gender identity of these individuals. Grade 6 and every single Grade7 ever recorded identified as female gender. This is supportive of the currently accepted medical facts that gender identity is set prenatally in certain areas of the brain by the exposure to testosterone and dihydrotestosterone at critical development points. There are at least a dozen known sexually dimorphic regions in the brain. These areas have some known associated instincts. This is why the common man for instance does not have or comprehend the want to have a baby that the common woman often reports. We as mammals have some differing sex based instinctual drives.
During my discovery of why I am how I am, I have learned much from research and various doctors. For instance, the specific effect of any AR mutation depends on the location of the chemical change within the gene.
In my case I had those external anomalies. I do identify as female in spite of trying to hide it and be a "normal man" in society. I had a delayed puberty. I did not grow body hair until into my thirties. I had minor gynocamastia starting as a teenager. My bone shapes are female. Yep our bones take on specific shapes and joint profiles in the first trimester of pregnancy and much like our external genitals react to testosterone or dihydrotestosterone. While not talked about much, certain pelvic joint profiles and bone scales are set prenatally. The sacroiliac joint shape is set then. This also sets the angle of the sacrum and creates the gap in the greater sciatic notch. The shape of the ilium is also set. When exposed to testosterone the ilium form more verticle and when not they form more outward. The angles of the knee joint and elbows is also different. While there is a large overlap in the common elbow angle of women and men, the knee angle can be much more telling. So in my case I did not have female puberty so I did not get the extra growth at the pubic symphasis in the front of my pelvis or greater hip spread before the pelvic bones finished fusing. However my pelvis fits into every other female standard so much that my primary doctor thought the lab had sent the wrong persons CT scan the first time he saw me. Interestingly though, I am one of a small percentage of Grade 2 PAIS patients who was still able to make viable sperm.
As someone who has lived dealing with being transgender and PAIS, I am quite willing to discuss the reality of this condition. So many forums are full of dismissive normal people who do not understand the real biology or the mental issues that come along with just being like me in society.
Diesel_Dummy rocky31676
Posted
josie07889 Diesel_Dummy
Posted
I was just explaining androgen insensitivity variations in 46XY chromosomal people like myself.
Idid not mean to exclude the struggles of people with trisomy chomosomal conditions like 47XXY or XYY or other conditions.
Diesel_Dummy josie07889
Posted
john75639 josie07889
Posted
Years ago, I met 2 women in Denver, c
Colorado (US) and they also were classified as female but in reality they were male. They were androgen insensitively. They had male testicles. Their parents re assigned them as females. Both are lovers, so in this society they would be considered a female to female couple, or lesbians. But the reality is they consider themselves males. But their appearances are definitely female.
So even in the gay community, they could be an oddity. I had no problem in recognizing them as a male couple. They didn't act female, but I may be a different kind of man.
I am a gay 47 xxy male who sometimes feel like a woman and other times a male. I have physical characteristics as a male but unwilling to undergo a sex change, to match what is missing on my body as a woman. I take testosterone injection because without the injections my testosterone levels is 34. Normal range is over 200.
I knew a bisexual male who had a hypospadias. He was over 60 but never had it repaired. His hole was near the base of his penis. He did tell me he had a child but lost contact with the mother and the child. At the time, I met him at a gay bathhouse, he as only interested in men for sex. That was 15 years ago. Where he is today is unknown.
Some xxy's don't consider themselves as intersexed. Some don't describe themselves as having Klinefelter Syndrome. Some xxy's are transgendered., they switch from male to females. I do not know of any female xxy's that have changed to males. Is it a possibility??
Most medical information on the internet only recognizes xxy's as males.
Changing androgen insensitively individuals to the wrong sex is cruel according to the intersexed community. At on time there was an organization called the Intersex Society but it no longer exists Their records were turned over to another organization, but I lost track of it.
At one xxy convention held in Denver years ago 2 xxy males starting to call themselves the new x men.
I myself refer to myself as a xyx male.
At the last xxy convention in Aurora Colorado, one medical doctor has been trying to change the xxy terminology; mainly because when talking about xxy, some people assume he is talking about females because of the xx. Even in the gay community, when I asked the person if they had a group of xxy's, I was told the lesbians meet at this certain day. I told him I was male, then he suggested that I may want to speak to a medical professional.
So I never question a person what sex they are because I am in a different category.
Should you see a doctor to see if my can be done about your situation.
If you don't like the results of your operation, then you need to find another doctor
Good luck, not many individuals are willing to open up about their lives. I thank you for your courage.
josie07889 john75639
Posted
I think there are several important things I have learned:
1: is that a person's chromosomes do not determine sex or gender. It's all works for most people but there is always the minority. Also that genital sex and gender wired in the brain do not always match.
2: not everyone gets wired with strictly "binary" male or female brains. Because those brain sections get set across a time span, some people end up partly wired with male and female instincts. I know that happens although I cannot understand their experience.
3: never doubt what another person says they experience.
Just my observations.
I'm not sure I understood some of what you posted. I am wired very female. I have no doubt of that. I transitioned to female life and hormones. I would eventually like to finish surgically, but untill I have the funds for GCS, I will be satisfied with having had an orchiectomy. Without testosterone in my system, I feel and think better than I can ever remember. Estrogen is just the right hormone for me.
Diesel_Dummy john75639
Posted
According to NIH, EU medical community, Australian/New Zealand, & many others, all XXY’s are intersex. North American Intersex Association still exists & keeps growing. InterACT has been pushing intersex agenda through California state legislature & is waiting on new laws for intersex people as we speak.
joshuapryce1987 rocky31676
Posted
I do not think health issues cause a person to act outside their gender, i think circumstances do that, and what people are exposed to.