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I am disgusted at the forthcoming ban of Co-proxamol, as stated in previous posts, at the end of this year (2007). For years I have suffered from anxiety and cronic pain. My GP prescribed various meds over the years: beta-blockers, anti-depressants, anti-psychotics (!), benzopines etc; nothing worked. I was (and am) practical house-bound, a normal lad who use to enjoy clubbing, chatting up girls, beer, apologising to girls :wink: , but *never* drugs, then BANG I was unable to function as a \"normal\" human. Years later I was prescribed Co-proxamol for the pain, after taking two tablets felt the \"edge\" wear off.
I soon tried 4 tablets and I was back to my normal self for around 5 hours at a time. Whilst on CP I was able to hold down a 12 hour a day job 6 days a week - yes I was taking up to 12 tablets a day (3x4) but never seemed to need more. I never built up a tolerance. I was worried, though, the effect of the paracetamol over the long term and cut down. I had to reduce the hours I worked but could still go clubbing, and quickly found out that drink and CP don't mix! Stuck to Cokes and Shandy and enjoyed the good old days again anyway.
I've read that Co-proxamol is no better than codine or paracetamol - this, in my opinion is wrong in my specific case. Paramol, an over the counter med with paracetamol and dihydrocodeine, has no affect on me - even at the double dose - either as a pain killer or anti-anxiety agent. My GP has now prescribed Tramadol - a stronger pain killer! -, as he can no longer prescribe Co-proxamol, but, again, at double dose it barely takes the edge (or pain) away.
I personally believe that the reason these stronger pain-killers have not worked for me is the way they react to the brain's opioid receptors, specifically the mu-opioid receptor, subset 3 (euphoria). The active ingredient in Co-proxamol, dextropropoxyphene, has a stronger effect on MuS3 than that of the other analgesic meds I've tried. In hospital I've been given Morphine - and this, like, CP made me my normal energetic self once more, if only for a few hours this; however, is not an option.
Again I must state that at no time did I build up a tolerance to CP for the years I was on it, and \"coming off it\" was fine - save for the fact I was back to my \"new\" old self - edgy, no energy, no motivation etc. Exactly as I been before taking the CP. Why a normal person went from normal to this almost melancholy state I may never know. I think it is a physical problem with the brain and it is not producing enough natural endophines.
I say again I never took illegal drugs as a kid/teen though I enjoyed many a beer - it's a mystery - and because of these new guidelines I have to suffer, and it is not on. Of-course the rich sufferers can go private and off-licence, if needed. The poor will have to do with heroin - luckly I hate needles and smoking!
Come on PCTs, GPs, MPs, Lords et al. sort it out please.
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