ESBRIET

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Has anyone with IPF had bad depression on Esbriet? I had to discontinue Ofev & have been on Esbriet for 3 months. The depression is terrible and so I had to lower the dose! This worrries me. Anyone else have this problem? God Bless You All!

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  • Posted

    My husband was also on ofev but after a year had to stop because of the side affects. He switched to esbriet and after a couple months had to quit that too because he had no energy and just no quality of life. Since hes been off he is back to normal but we are worried that he is not on any meds right now to slow this disease.
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    • Posted

      Thanks for that info Ladykatherine! I have gone off Esbriet, too, for the exact same reasons. I see my pulmonary doc o. May 19th so Ill let you know what he says. Good luck to your husband! 
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  • Posted

    Send toRev Pneumol Clin.1985;41(2):91-100.[Respiratory function and alveolar biological changes under the effect of CDP-choline in pulmonary interstitial pathology: pulmonary fibrosis and sarcoidosis].[Article in French]

    Pacheco Y, Douss T, Pujol B, Revol A, Vergnon JM, Biot N, Brune J, Perrin-Fayolle M.Abstract

    Various anomalies of pulmonary surfactant have been described in relation to acute respiratory distress syndromes, hypersensitivity lung disease and pulmonary sarcoidosis. Phosphatidylcholine (PC) is the essential phospholipid component of pulmonary surfactant. Cytidine diphosphocholine (CDP-choline) is an essential intermediary in the biosynthesis of PC. The authors studied two groups of patients: one group consisted of diffuse interstitial pulmonary fibrosis and the other consisted of pulmonary sarcoidosis with parenchymal involvement. They observed quantitative and qualitative abnormalities of the phospholipid fractions of surfactant and more particularly of PC. The finding of a marked decrease in this phospholipid, especially in the cases of pulmonary fibrosis, justified the study of the therapeutic effects of CDP-choline. After one month of treatment with this substance, at a dose of 1 g I.M. per day, the PC fraction had returned to normal and, at the same time, there was an improvement in the PaO2 at rest and after exercise. Long term administration of CDP-choline appears to be valuable in the maintenance of the phospholipid equilibrium of pulmonary surfactant and in the improvement of the quality of alveolar gas exchange.

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    • Posted

      HI Adrienne,

      I know it's been 9 months but I didn't have my notifications turned on! Can you please explain the info you sent to me? Thanks so much.

      Teri Brown

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