Platelet level too high?
Posted , 6 users are following.
hello all,
It's been a while since I posted. Went back to work since the beginning of the year. Haven't felt that good for years. I think I have had symptoms at least 2 years prior to my diagnosis, fatigue, migraines, itchy feet. Since starting treatments, venesections and Aspirine, most of it is gone, no fatigue, no migraines and no itching, I feel so much better. I have venesections every two weeks now until my hematocrite reaches 45. The last 2 appointments, it was at 46, but my platelets jumped to 925 the last time. I am worried that my Dr puts me on meds because of my platelets. What is the risks of having high platelets?
I don't want to put myself at risk, but I feel so good right now and I am worried about the side effects of medication.
1 like, 23 replies
angela_o..o marie-jos6518
Posted
Wow, I knew that there was something dodgy about grapefruit but I didn't know that it was as serious as this.
http://www.nhs.uk/news/2012/11November/Pages/Prescription-pills-and-grapefruit-a-deadly-mix.aspx
Also, marmalade! Who knew?
Zapamania angela_o..o
Posted
Hi Angela thanks for the research, good job.. And the marmalade is citrus based. So let's all stay away from citrus products. We,ve got enough problems and don't need anymore. Zap
lijuan7002 marie-jos6518
Posted
A high platelet count can lead to dangerous blood clotting if left untreated.
Aspirine may not a good choice for your condition!
Ropeginterferon alfa-2b, a novel IFNα-2b, induces high response rates with low toxicity in patients with polycythemia vera.
You should think about using the new generation PEG-Interferon-alpha-2b to control your high platelet count.
I think the new generation interferon may a good choice for a permanent cure !!
Best wishes
frances20411 lijuan7002
Posted
is the source valid??? What country are you in.???
Have you personally used the PEG to help with your platelet count.
Are you also on other Meds..to help or doing anything regarding diet
exercise?? Thank you for your response.
lijuan7002 frances20411
Posted
Hi Frances,
As far as I know, there are no FDA-approved first-line drug treatments for PV at present.
Doctors may suggest use of a "Off-label drug" based on high quality research studies published in peer-reviewed journals and widely accepted throughout the medical community.(e.g., HU, Aspirin, etc.)
However the Off-label drug just take temporary solution not effect a permanent cure! In some cases, the treatment of HU is lifelong.
But Off-label drug may not a good coice for PV!
The specific JAK2 V617F mutation is detected in >95% of patients with PV.
And JAK2 V617F mutation is the key driver of PV!
You can visit the ASH website to get the latest clinical Information about PV.
Ppaer1:
Impact on MPN Symptoms and Quality of Life of Front Line Pegylated Interferon Alpha-2a Vs. Hydroxyurea in High Risk Polycythemia Vera and Essential Thrombocythemia: Interim Analysis Results of Myeloproliferative Disorders Research Consortium (MPD-RC) 112 Global Phase III Trial
Paper 2:
Final Results from PROUD-PV a Randomized Controlled Phase 3 Trial Comparing Ropeginterferon Alfa-2b to Hydroxyurea in Polycythemia Vera Patients
I think the new generation interferon may a good choice for a permanent cure !!
Best wishes