Rituximab and methotrexate

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My husband has had hoarseness and been coughing for about a month. He went to the Dr. On Wednesday and they started him on methotrexate and they want him to get 1 round of chemo (4 infusions) soon. Is anyone else on both medications at the same time? I just think it's a lot! But I'm no Dr. Either and want what's best for my husband.

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  • Posted

    Well my Dr. said hoareness has nothing to do with wg for me mine comes and goes. I think I need new Dr.
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    • Posted

      I read on web md or some website hoarseness can be a symptom and with my husband WG affects his respiratory system, he already has scaring in his lungs and his dr. Told him that the swelling he is feeling in his throat along with the hoarseness is the WG coming back, because of the possibility of his windpipe collapsing he needed to be treated.

      I hope that you find the right Dr. We are seeing a rheumatologist and he is the only Dr. we finally trust and like. Best wishes to you!

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  • Posted

    Hi Courtney

    I've not been on both together. This may help? ..

    Summary features of the NICE guidance relating to the use of rituximab is outlined below:

    rituximab in combination with methotrexate is recommended as an option for the treatment of adults with severe active rheumatoid arthritis who have had an inadequate response to or intolerance of other disease-modifying anti-rheumatic drugs (DMARDs), including treatment with at least one tumour necrosis factor a (TNF-a) inhibitor therapy

    treatment with rituximab plus methotrexate should be continued only if there is an adequate response following initiation of therapy. An adequate response is defined as an improvement in disease activity score (DAS28) of 1.2 points or more. Repeat courses of treatment with rituximab plus methotrexate should be given no more frequently than every 6 months

    treatment with rituximab plus methotrexate should be initiated, supervised and treatment response assessed by specialist physicians experienced in the diagnosis and treatment of rheumatoid arthritis

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