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Statins help with MCAS?

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JaneTx
JaneTx

Was curious - has anybody with MCAS had a reduction in symptoms when taking statins for high cholesterol, particularly Fluvastatin?  I ran across an article in The Journal of Immunology called "Fluvastatin induces mast cell apoptosis and autophagy..." (apoptosis: cell death)  As it seems to me that reactions increasing in severity might be a result of more and more mast cells collecting in tissues over time, a strategy might be to somehow encourage mast cells to age-out and die.  I've heard nothing but bad things about statin drugs, but most of the side effects are over a longer period of time and maybe short courses might be useful for MCAS treatment.  Just a thought.

0 likes, 2 replies

2 Replies

  • grampat01
    grampat01 JaneTx

    Posted

    I took simvastatin for about a year and did not notice any change in my mast cell production .
    • JaneTx
      JaneTx grampat01

      Posted

      Thanks!  The couple of references I ran across was specifically with Fluvastatin, I don't know how they might be different.

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