Doxepin cream
Xepin
Peer reviewed by Sid DajaniLast updated by Michael Stewart, MRPharmSLast updated 19 Jan 2025
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Doxepin cream helps to reduce itching associated with eczema.
Apply a thin layer of cream three or four times a day.
It can make you feel sleepy. If this happens, do not drive and do not use tools or machines.
At a glance
Doxepin cream is an antipruritic cream for adults and children over 12.
It helps reduce itching from eczema by blocking histamine.
Apply a thin layer to itchy areas three or four times daily, up to 12g per day.
It can cause sleepiness; avoid driving or using machinery if affected.
Do not drink alcohol or use dressings over the cream unless advised by your doctor.
Tell your doctor if you have a heart condition, glaucoma, or liver problems before using it.
If skin irritation occurs, stop using the cream and see your doctor.
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About doxepin cream
Type of medicine | An antipruritic cream |
Used for | Itching due to eczema (in adults and in children over 12 years of age) |
Also called | Xepin® |
Available as | Cream |
Eczema is sometimes called dermatitis, which means inflammation of the skin. If you have eczema, areas of your skin become dry, red and inflamed. These areas of inflamed skin are often itchy, making you want to scratch. Then when you scratch, your skin becomes even more inflamed.
Doxepin cream helps to reduce itching in people with eczema. It does this by blocking the action of a substance in your body, called histamine.
Before using doxepin cream
Back to contentsTo make sure this is the right treatment for you, before you start using doxepin cream it is important that your doctor knows:
If you are pregnant or breastfeeding.
If you have a heart condition or an irregular heart rhythm.
If you have increased pressure in your eye, a condition called glaucoma.
If you have any difficulties passing urine.
If you have any problems with the way your liver works.
If you have a mood disorder called mania.
If you have ever had an allergic reaction to a medicine.
If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
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How to use doxepin cream
Back to contentsBefore you start using the cream, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about doxepin cream, and it will also provide you with a full list of side-effects which you could experience from using it.
Apply a thin layer of doxepin cream to the itchy areas three or four times each day. It is recommended that you do not use more than 3 g of cream at any time, or more than 12 g of cream a day. As a rough guide, this means that you should never use so much that a 30 g tube of cream lasts less than three days.
Getting the most from your treatment
Back to contentsDoxepin cream may make you feel sleepy, especially when you first start using it. If it happens to you, do not drive and do not use tools or machines while you are affected. If it continues to be a problem, apply less cream or, for a few days, reduce the number of times you apply it. You should not drink alcohol while you are using the cream as this can make the sleepiness worse.
If the treated areas of your skin are covered (either with your clothing or a dressing), this can increase how much doxepin your skin absorbs and the risk of side-effects. Do not apply more of the cream than your doctor has told you to, and do not use any dressings over the cream unless your doctor has said to do so.
Continue to use your emollients every day as this will also help to prevent your skin from becoming dry and itchy. Try to avoid extremes of temperature by wrapping up well in cold weather. Also, avoid wearing rough or irritating clothing which can make your itching worse.
If you buy any medicines, check with a pharmacist that they are suitable for you to take while you are using doxepin.
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Can doxepin cream cause problems?
Back to contentsAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains the most common ones associated with doxepin cream. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any continue or become troublesome.
Very common doxepin cream side-effects (these affect more than 1 in 10 people) | What can I do if I experience this? |
Feeling sleepy or dizzy | If this happens, do not drive and do not use tools or machines. Do not drink alcohol. Try applying smaller amounts of cream or using it less often |
Less common doxepin cream side-effects | What can I do if I experience this? |
Burning, stinging or tingling of your skin | This should soon pass but you can try using less cream for a few days |
Rash | This could be an allergic type of reaction. Stop using the cream and see your doctor for further advice |
If you experience any other symptoms which you think may be due to the cream, speak with your doctor or pharmacist for further advice.
How to store doxepin cream
Back to contentsKeep all medicines out of the reach and sight of children.
Store in a cool, dry place, away from direct heat and light.
Important information about all medicines
Back to contentsImportant information about all medicines
This cream is for use on the skin only. If someone swallows some of it, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
If you are having an operation or any dental treatment, tell the person carrying out the treatment which medicines you are taking or using.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
Report side effects to a medicine or vaccine
If you experience side effects, you can report them online through the Yellow Card website.

Unsure about mixing medicines?
Check for possible interactions between medicines, supplements and foods before taking them together.
Frequently asked questions
What is the maximum duration I can use doxepin cream?
The article provides guidelines for the amount of doxepin cream to use per application and per day (no more than 3g at any time, or 12g per day, lasting at least three days for a 30g tube). However, it does not specify a maximum duration for treatment. For questions about how long to use the cream, it's best to consult your doctor or pharmacist.
Will doxepin cream interact with my other skincare products or moisturisers?
The article mentions continuing to use emollients daily to prevent dry and itchy skin while using doxepin cream. However, it does not specifically discuss interactions with other skincare products. It advises checking with a pharmacist about any other medicines you buy, which would include over-the-counter skincare, to ensure they are suitable for use with doxepin.
What should I do if I accidentally get doxepin cream in my eyes or mouth?
The article states that the cream is for use on the skin only. It advises going to accident and emergency if someone swallows some of it. For accidental contact with eyes or mouth, although not explicitly stated, it would be prudent to rinse the affected area thoroughly and seek further advice from your doctor or pharmacist if irritation persists, given the cream's active ingredients and warnings about side effects.
Can children under 12 years old use doxepin cream for eczema?
Doxepin cream is indicated for itching due to eczema in adults and in children over 12 years of age. This means it is not recommended for children under 12.
Will doxepin cream stain my clothes or bedding?
The article does not contain information about whether doxepin cream will stain clothing or bedding. When using topical creams, it's often a good practice to allow the cream to absorb before dressing or coming into contact with fabrics, but specific staining properties for doxepin cream are not mentioned.
What should I do if my itching does not improve after using doxepin cream?
The article does not explicitly state what to do if the itching does not improve. It does mention speaking with your doctor or pharmacist if any side effects continue or become troublesome, or if you experience any other symptoms you think may be due to the cream. If the cream isn't providing the intended relief for your itching, it would be appropriate to consult your doctor or pharmacist for further advice, as the treatment might need to be re-evaluated.
Further reading and references
- Manufacturer's PIL, Xepin® 5% cream; Cambridge Healthcare Supplies ltd. Medicines and Healthcare products Regulatory Agency (MHRA). Dated March 2015.
- Medicines Complete BNF 89th Edition; British Medical Association and Royal Pharmaceutical Society of Great Britain, London.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Next review due: 19 Jan 2028
19 Jan 2025 | Latest version

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